Mast cell inhibition and reduced ventricular arrhythmias in a swine model of acute myocardial infarction upon therapeutic administration of relaxin

Inflammation Research

Volumn 57, Issue SUPPL. 1, 2008, Pages

  Nistri, S ^a   Cinci, L ^a   Perna, A M ^b   Masini, E ^a   Bani, D ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b CAREGGI UNIVERSITY HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HISTAMINE; RELAXIN; RLN2 PROTEIN, HUMAN;

ACUTE HEART INFARCTION; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; HEART VENTRICLE ARRHYTHMIA; HISTAMINE BLOOD LEVEL; MALE; MAST CELL; MYOCARDITIS; NONHUMAN; REPERFUSION INJURY; SWINE; ANIMAL; ARTICLE; DISEASE MODEL; HEART ARRHYTHMIA; HEART INFARCTION; HEART VENTRICLE; HUMAN; METABOLISM; PATHOPHYSIOLOGY;

ANIMALS; ARRHYTHMIAS, CARDIAC; DISEASE MODELS, ANIMAL; HEART VENTRICLES; HISTAMINE; HUMANS; MALE; MAST CELLS; MYOCARDIAL INFARCTION; RELAXIN; REPERFUSION INJURY; SWINE;

EID: 43249111949     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-007-0602-6     Document Type: Conference Paper

References (8)

1. Giotti A, Guidotti A, Mannaioni PF, Zilletti L. The infl uences of adrenotropic drugs and noradrenaline on the histamine release in cardiac anaphylaxis in vitro. J Physiol 1966; 184: 924-41.
2. Keller AM, Clancy RM, Barr ML, Marboe CC, Cannon PJ. Acute reoxygenation injury in the isolated rat heart: role of resident cardiac mast cells. Circ Res 1988; 63: 1044-52.
3. Masini E, Bani D, Bigazzi M, Mannaioni PF, Bani Sacchi T. Effects of relaxin on mast cells. In vitro and in vivo studies in rats and guinea pigs. J Clin Invest 1994; 94: 1974-80.
4. Bani D, Baronti R, Vannacci A, Bigazzi M, Bani Sacchi T, Mannaioni PF, Masini E: Inhibitory effects of relaxin on human basophils activated by stimulation of the FC receptor. The role of nitric oxide. Int Immunopharmacol 2002; 2: 1195-204.
5. Nistri S, Bigazzi M, Bani D. Relaxin as a cardiovascular hormone. Physiology, pathophysiology and therapeutic promises. Cardiovascular and Hematological Agents in Medicinal Chemistry (CHAMC) 2007; 5: 101-8.
6. Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD, Hsueh AJW. Activation of orphan receptors by the hormone relaxin. Science 2002; 295: 671-3.
7. Perna AM, Masini E, Nistri S, Briganti V, Chiappini L, Stefano P, Bigazzi M, Pieroni C, Bani Sacchi T, Bani D. Novel drug development opportunity for relaxin in acute myocardial in farction: evidences from a swine model. FASEB J 2005; 19: 1525-7.
8. Masini E, Planchenault J, Pezziardi F, Gautier P, Gagnol JP: Histamine-releasing properties of Polysorbate 80 in vitro and in vivo: correlation with its hypotensive action in the dog. Agents Actions 1985; 16: 470-7.