The effect of gastric acid on the absorption of posaconazole

Clinical Infectious Diseases

Volumn 46, Issue 10, 2008, Pages 1627-

  Jain, Rupali ^a,b   Pottinger, Paul ^a  

^a UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIMETIDINE; CYTOCHROME P450; HISTAMINE H2 RECEPTOR ANTAGONIST; POSACONAZOLE; PROTON PUMP INHIBITOR; ANTIFUNGAL AGENT; TRIAZOLE DERIVATIVE;

AREA UNDER THE CURVE; DRUG ABSORPTION; DRUG INFORMATION; DRUG MANUFACTURE; ENZYME INHIBITION; HUMAN; LETTER; MAXIMUM PLASMA CONCENTRATION; PRIORITY JOURNAL; STOMACH ACID; STOMACH PH; DRUG INTERACTION; NOTE;

ANTIFUNGAL AGENTS; CIMETIDINE; DRUG INTERACTIONS; GASTRIC ACID; HUMANS; TRIAZOLES;

EID: 43249109106     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/587755     Document Type: Letter

References (5)

1. Nagappan V, Deresinski S. Posaconazole: a broad-spectrum triazole antifungal agent. Clin Infect Dis 2007; 45:1610-17.
2. Courtney R, Radwanski E, Lim J, Laughlin M. Pharmacokinetics of posaconazole coadministered with antacid in fasting or nonfasting healthy men. Antimicrob Agents Chemother 2004; 48:804-8.
3. Noxafil (posaconazole) oral suspension [package insert]. Kenilworth, NJ: Schering-Plough, 2006.
4. Walsh TJ, Raad I, Patterson TF, et al. Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial. Clin Infect Dis 2007; 44:2-12.
5. Krishna G, Martinho M, Chandrasekar P, Ullmann AJ, Patino H. Pharmacokinetics of oral posaconazole in allogeneic hematopoietic stem cell transplant recipients with graft-versus-host disease. Pharmacotherapy 2007; 27:1627-36.