메뉴 건너뛰기




Volumn 8, Issue 5, 2008, Pages 687-689

Cystatin C: A potential target for Alzheimer's treatment

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CYSTATIN C;

EID: 43249100084     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/14737175.8.5.687     Document Type: Editorial
Times cited : (26)

References (22)
  • 1
    • 0026806875 scopus 로고
    • Cystatins - inhibitors of cysteine proteinases
    • Bobek LA, Levine MJ. Cystatins - inhibitors of cysteine proteinases. Crit. Rev. Oral. Biol. Med. 3, 307-332 (1992).
    • (1992) Crit. Rev. Oral. Biol. Med , vol.3 , pp. 307-332
    • Bobek, L.A.1    Levine, M.J.2
  • 2
    • 0025371978 scopus 로고
    • Immunoreactive A4 and γ-trace peptide colocalization in amyloidotic arteriolar lesions in brains of patients with Alzheimer's disease
    • Vinters HV, Nishimura GS, Secor DL, Pardridge WM. Immunoreactive A4 and γ-trace peptide colocalization in amyloidotic arteriolar lesions in brains of patients with Alzheimer's disease. Am. J. Pathol. 137, 233-240 (1990).
    • (1990) Am. J. Pathol , vol.137 , pp. 233-240
    • Vinters, H.V.1    Nishimura, G.S.2    Secor, D.L.3    Pardridge, W.M.4
  • 3
    • 0025344074 scopus 로고
    • Immunohistochemical characterization of cerebrovascular amyloid in 46 autopsied cases using antibodies to β protein and cystatin C
    • Maruyama K, Ikeda S, Ishihara T, Allsop D, Yanagisawa N. Immunohistochemical characterization of cerebrovascular amyloid in 46 autopsied cases using antibodies to β protein and cystatin C. Stroke 21, 397-403 (1990).
    • (1990) Stroke , vol.21 , pp. 397-403
    • Maruyama, K.1    Ikeda, S.2    Ishihara, T.3    Allsop, D.4    Yanagisawa, N.5
  • 4
    • 0027314209 scopus 로고
    • Cerebral amyloid angiopathy: A significant cause of cerebellar as well as lobar cerebral hemorrhage in the elderly
    • Itoh Y, Yamada M, Hayakawa M, Otomo E, Miyatake T. Cerebral amyloid angiopathy: a significant cause of cerebellar as well as lobar cerebral hemorrhage in the elderly. J. Neurol. Sci. 116, 135-141 (1993).
    • (1993) J. Neurol. Sci , vol.116 , pp. 135-141
    • Itoh, Y.1    Yamada, M.2    Hayakawa, M.3    Otomo, E.4    Miyatake, T.5
  • 5
    • 0028335790 scopus 로고
    • Co-localization of β/A4 and cystatin C in cortical blood vessels in Dutch, but not in Icelandic hereditary cerebral hemorrhage with amyloidosis
    • Haan J, Maat-Schieman MLC, van Duinen SG, Jensson O, Thorsteinsson L, Roos RAC. Co-localization of β/A4 and cystatin C in cortical blood vessels in Dutch, but not in Icelandic hereditary cerebral hemorrhage with amyloidosis. Acta Neurol. Scand. 89, 367-371 (1994).
    • (1994) Acta Neurol. Scand , vol.89 , pp. 367-371
    • Haan, J.1    Maat-Schieman, M.L.C.2    van Duinen, S.G.3    Jensson, O.4    Thorsteinsson, L.5    Roos, R.A.C.6
  • 6
    • 0035140013 scopus 로고    scopus 로고
    • Codeposition of cystatin C with amyloid-β protein in the brain of Alzheimer's disease patients
    • Levy E, Sastre M, Kumar A et al. Codeposition of cystatin C with amyloid-β protein in the brain of Alzheimer's disease patients. J. Neuropathol. Exp. Neurol. 60, 94-104 (2001).
    • (2001) J. Neuropathol. Exp. Neurol , vol.60 , pp. 94-104
    • Levy, E.1    Sastre, M.2    Kumar, A.3
  • 7
    • 0029829459 scopus 로고    scopus 로고
    • Icelandic-like mutation in an animal model of cerebrovascular β amyloidosis
    • Wei L, Walker LC, Levy E. Cystatin C: Icelandic-like mutation in an animal model of cerebrovascular β amyloidosis. Stroke 27, 2080-2085 (1996).
    • (1996) Stroke , vol.27 , pp. 2080-2085
    • Wei, L.1    Walker, L.C.2    Levy, E.3    Cystatin, C.4
  • 8
    • 0031042383 scopus 로고    scopus 로고
    • Immunohistochemical study of constituents other than β-protein in canine senile plaques and cerebral amyloid angiopathy
    • Uchida K, Kuroki K, Yoshino T, Yamaguchi R, Tateyama S. Immunohistochemical study of constituents other than β-protein in canine senile plaques and cerebral amyloid angiopathy. Acta Neuropathol. (Berl.) 93, 277-284 (1997).
    • (1997) Acta Neuropathol. (Berl.) , vol.93 , pp. 277-284
    • Uchida, K.1    Kuroki, K.2    Yoshino, T.3    Yamaguchi, R.4    Tateyama, S.5
  • 9
    • 0034877781 scopus 로고    scopus 로고
    • Increased cystatin C in astrocytes of transgenic mice expressing the K670N-M671L mutation of the amyloid precursor protein and deposition in brain amyloid plaques
    • Steinhoff T, Moritz E, Wollmer MA, Mohajeri MH, Kins S, Nitsch RM. Increased cystatin C in astrocytes of transgenic mice expressing the K670N-M671L mutation of the amyloid precursor protein and deposition in brain amyloid plaques. Neurobiol. Dis. 8, 647-654 (2001).
    • (2001) Neurobiol. Dis , vol.8 , pp. 647-654
    • Steinhoff, T.1    Moritz, E.2    Wollmer, M.A.3    Mohajeri, M.H.4    Kins, S.5    Nitsch, R.M.6
  • 10
    • 2942737051 scopus 로고    scopus 로고
    • Sastre M, Calero M, Pawlik M et al. Binding of cystatin C to Alzheimer's amyloid β inhibits amyloid fibril formation. Neurobiol. Aging 25, 1033-1043 (2004). •• Established for the first time the binding of amyloid-β (Aβ) to cystatin C and resultant inhibition of Aβ aggregation.
    • Sastre M, Calero M, Pawlik M et al. Binding of cystatin C to Alzheimer's amyloid β inhibits amyloid fibril formation. Neurobiol. Aging 25, 1033-1043 (2004). •• Established for the first time the binding of amyloid-β (Aβ) to cystatin C and resultant inhibition of Aβ aggregation.
  • 11
    • 3042820505 scopus 로고    scopus 로고
    • Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid β peptide
    • Pawlik M, Sastre M, Calero M et al. Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid β peptide. J. Mol. Neurosci. 22, 13-18 (2004).
    • (2004) J. Mol. Neurosci , vol.22 , pp. 13-18
    • Pawlik, M.1    Sastre, M.2    Calero, M.3
  • 12
    • 39149095264 scopus 로고    scopus 로고
    • The in vivo brain interactome of the amyloid precursor protein
    • Bai Y, Markham K, Chen F et al. The in vivo brain interactome of the amyloid precursor protein. Mol. Cell. Proteomics 7, 15-34 (2008).
    • (2008) Mol. Cell. Proteomics , vol.7 , pp. 15-34
    • Bai, Y.1    Markham, K.2    Chen, F.3
  • 13
    • 33947133671 scopus 로고    scopus 로고
    • Cystatin C reduces the in vitro formation of soluble Aβ1-42 oligomers and protofibrils
    • Demonstrated that cystatin C decreases Aβ oligomerization, ••
    • Selenica ML, Wang X, Ostergaard-Pedersen L, Westlind-Danielsson A, Grubb A. Cystatin C reduces the in vitro formation of soluble Aβ1-42 oligomers and protofibrils. Scand. J. Clin. Lab. Invest. 67, 179-190 (2007). •• Demonstrated that cystatin C decreases Aβ oligomerization.
    • (2007) Scand. J. Clin. Lab. Invest , vol.67 , pp. 179-190
    • Selenica, M.L.1    Wang, X.2    Ostergaard-Pedersen, L.3    Westlind-Danielsson, A.4    Grubb, A.5
  • 14
    • 36549043900 scopus 로고    scopus 로고
    • Cystatin C inhibits amyloid-β deposition in Alzheimer's disease mouse models
    • Revealed the in vivo binding of soluble Aβ to cystatin C, resulting in inhibition of Aβ plaque formation in the brain of transgenic mice, ••
    • Mi W, Pawlik M, Sastre M et al. Cystatin C inhibits amyloid-β deposition in Alzheimer's disease mouse models. Nat. Genet. 39, 1440-1442 (2007). •• Revealed the in vivo binding of soluble Aβ to cystatin C, resulting in inhibition of Aβ plaque formation in the brain of transgenic mice.
    • (2007) Nat. Genet , vol.39 , pp. 1440-1442
    • Mi, W.1    Pawlik, M.2    Sastre, M.3
  • 15
    • 36549085086 scopus 로고    scopus 로고
    • Cystatin C modulates cerebral β-amyloidosis
    • Revealed the in vivo binding of soluble Aβ to cystatin C, resulting in inhibition of Aβ plaque formation in the brain of transgenic mice, ••
    • Kaeser SA, Herzig MC, Coomaraswamy J et al. Cystatin C modulates cerebral β-amyloidosis. Nat. Genet. 39, 1437-1439 (2007). •• Revealed the in vivo binding of soluble Aβ to cystatin C, resulting in inhibition of Aβ plaque formation in the brain of transgenic mice.
    • (2007) Nat. Genet , vol.39 , pp. 1437-1439
    • Kaeser, S.A.1    Herzig, M.C.2    Coomaraswamy, J.3
  • 17
    • 33646576172 scopus 로고    scopus 로고
    • The role of cystatin C in cerebral amyloid angiopathy and stroke: Cell biology and animal models
    • Levy E, Jaskolski M, Grubb A. The role of cystatin C in cerebral amyloid angiopathy and stroke: cell biology and animal models. Brain Pathol. 16, 60-70 (2006).
    • (2006) Brain Pathol , vol.16 , pp. 60-70
    • Levy, E.1    Jaskolski, M.2    Grubb, A.3
  • 18
    • 33846574690 scopus 로고    scopus 로고
    • Presenilin 2 mutations alter cystatin C trafficking in mouse primary neurons
    • Ghidoni R, Benussi L, Paterlini A et al. Presenilin 2 mutations alter cystatin C trafficking in mouse primary neurons. Neurobiol. Aging 28, 371-376 (2006).
    • (2006) Neurobiol. Aging , vol.28 , pp. 371-376
    • Ghidoni, R.1    Benussi, L.2    Paterlini, A.3
  • 19
    • 0033733370 scopus 로고    scopus 로고
    • Finckh U, von Der Kammer H, Velden J et al. Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease. Arch. Neurol. 57, 1579-1583 (2000).
    • Finckh U, von Der Kammer H, Velden J et al. Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease. Arch. Neurol. 57, 1579-1583 (2000).
  • 20
    • 0038399757 scopus 로고    scopus 로고
    • Alzheimer disease-associated cystatin C variant undergoes impaired secretion
    • Benussi L, Ghidoni R, Steinhoff T et al. Alzheimer disease-associated cystatin C variant undergoes impaired secretion. Neurobiol. Dis. 13, 15-21 (2003).
    • (2003) Neurobiol. Dis , vol.13 , pp. 15-21
    • Benussi, L.1    Ghidoni, R.2    Steinhoff, T.3
  • 22
    • 43249124670 scopus 로고    scopus 로고
    • Gene overview of all published AD association studies for
    • Gene overview of all published AD association studies for CST3. www.alzforum.org/res/com/gen/alzgene/geneoverview.asp?geneid=66
    • CST3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.