Radiosynthesis of novel 18F-labelled derivatives of indiplon as potential GABAA receptor imaging tracers for PET

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 51, Issue 3, 2008, Pages 123-131

  Fischer, Steffen ^a,e   Hiller, Achim ^a   Scheunemann, Matthias ^a   Deuther Conrad, Winnie ^a   Hoepping, Alexander ^b   Diekers, Michael ^b   Wegner, Florian ^c   Brust, Peter ^a   Steinbach, Jörg ^a,d  

^a Institute of Interdisciplinary Isotope Research   (Germany)

^b ABX Advanced Biochemical Compounds GmbH   (Germany)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

^e Institut fur Interdisziplinare Isotopenforschung   (Germany)

Author keywords

18F labelled indiplon derivatives; GABAA receptor; PET

Indexed keywords

BRAIN MAPPING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHASE SEPARATION;

18F-LABELED INDIPLON DERIVATIVE; ACID RECEPTORS; BENZODIAZEPINES; BRAIN IMAGING; GAMMA AMINO BUTYRIC ACIDA RECEPTOR; NEUROLOGICAL DISEASE; PSYCHIATRIC DISEASE; RADIOCHEMICAL YIELD; RADIOLIGANDS; RADIOSYNTHESIS;

BUTYRIC ACID;

2 BROMO N METHYL N [3 [3 (THIOPHENE 2 CARBONYL)PYRAZOLO[ 1,5 A]PYRIMIDIN 7 YL]PHENYL]ACETAMIDE F 18; 2 FLUORO N METHYL N [3 [3 (THIOPHENE 2 CARBONYL)PYRAZOLO[1,5 A]PYRIMIDIN 7 YI]PHENYL]ACETAMIDE F 18; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 FLUORO N METHYL N [3 [3 (THIOPHENE 2 CARBONYL)PYRAZOLO[1,5 A]PYRIMIDIN 7 YL]PHENYL]BENZAMIDE F 18; 4 NITRO N METHYL N [3 [3 (THIOPHENE 2 CARBONYL)PYRAZOLO[1,5 A]PYRIMIDIN 7 YL]PHENYL]BENZAMIDE F 18; INDIPLON; INDIPLON F 18; N (2 FLUOROETHYL) N [3 [3 (THIOPHENE 2 CARBONYL)PYRAZOLO[1,5 A]PYRIMIDIN 7 YL]PHENYL]ACETAMIDE F 18; N (3 FLUOROPROPYL) N [3 [3 (THIOPHENE 2 CARBONYL)PYRAZOLO[1,5 A]PYRIMIDIN 7 YL]PHENYL]ACETAMIDE F 18; N 4 FLUOROBUTYL N [3 [3 (THIOPHENE 2 CARBONYL)PYRAZOLO(1,5 A]PYRIMIDIN 7 YL]PHENYL]ACETAMIDE F 18; N [3 [3 (THIOPHENE 2 CARBONYL) PYRAZOLO[1,5 A]PYRIMIDIN 7 YL]PHENYL] N [4 (TOLUENE 4 SULFONYLOXY)PROPYL]ACETAMIDE F 18; N [3 [3 (THIOPHENE 2 CARBONYL)PYRAZOLO[1,5 A]PYRIMIDIN 7 YL]PHENYL] N [4 (TOLUENE 4 SULFONYLOXY)BUTYL]ACETAMIDE F 18; TRACER;

ARTICLE; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; POSITRON EMISSION TOMOGRAPHY; RADIOCHEMISTRY; REACTION ANALYSIS; SUBSTITUTION REACTION;

EID: 43149109495     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1473     Document Type: Article

References (26)