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Volumn 51, Issue 4, 2008, Pages 175-181
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Synthesis of the tritiated isotopomers of enzastaurin and its N-des-pyridylmethyl metabolite for use in ADME studies
a
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Author keywords
AKT; Enzastaurin; PKC; Tritiated; VEGF
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Indexed keywords
AROMATIC COMPOUNDS;
PHYSIOLOGY;
AKT;
ENZASTAURIN;
IN-PHASE;
ISOTOPOMERS;
PHASE II;
PKC;
POTENTIAL UTILITY;
SOLID TUMORS;
TRITIATED;
VEGF;
METABOLISM;
3 (1 METHYL 1H INDOL 3 YL) 4 (1 PIPERIDIN 4 YL 1H INDOL 3 YL)PYRROLE 2,5 DIONE;
3 (1 METHYL 1H INDOL 3 YL) 4 [1 [1 (2 PYRIDINYLMETHYL) 4 PIPERIDINYL] 1H INDOL 3 YL] 1H PYRROLE 2,5 DIONE;
3 (1 METHYL[3 H3] 1H INDOL 3 YL) 4 (1 PIPERIDIN 4 YL 1H INDOL 3 YL)PYRROLE 2,5 DIONE(1 [3 H]);
3 (1 METHYL[3 H3] 1H INDOL 3 YL) 4 (1 PIPERIDIN 4 YL 1H INDOL 3 YL)PYRROLE 2,5 DIONE(2 [3 H3]);
4 [3 [4 (1 METHYL 1H INDOL 3 YL) 2,5 DIHYDRO 1H PYRROLO 3 YL]INDOL 1 YL]PIPERIDINE 1 CARBOXYLIC ACID TERT BUTYL ESTER;
4 [3 [4 (1 METHYL 1H INDOL 3 YL) 2,5 DIOXO 2,5 DIHYDROFURAN 3 YL]INDOL 1 YL]PIPERIDINE 1 CARBOXYLIC ACID TERT BUTYL ESTER;
4 [3 [4 (1 METHYL[3 H3] 1H INDOL 3 YL) 2,5 DIHYDROFURAN 3 YL]INDOL 1 YL]PIPERIDINE 1 CARBOXYLIC ACID TERT BUTYL ESTER;
4 [3 [4 (1H INDOL 3 YL) 1 METHYL 2,5 DIOXO 1H PYRROL 3 YL]INDOL 1 YL]PIPERIDINE 1 CARBOXYLIC ACID TERT BUTYL ESTER;
4 [3 [4 (1H INDOL 3 YL) 2,5 DIOXO 2,5 DIHYDROFURAN 3 YL]INDOL 1 YL]PIPERIDINE 1 CARBOXYLIC ACID TERT BUTYL ESTER;
DRUG METABOLITE;
ENZASTAURIN;
HYDROGEN;
TRITIUM;
ARTICLE;
DRUG STRUCTURE;
DRUG SYNTHESIS;
MASS SPECTROMETRY;
NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;
PROTON NUCLEAR MAGNETIC RESONANCE;
TITRIMETRY;
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EID: 43149104970
PISSN: 03624803
EISSN: 10991344
Source Type: Journal
DOI: 10.1002/jlcr.1497 Document Type: Article |
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Times cited : (8)
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References (10)
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