Use of imiquimod 5% cream (Aldara™) in cats with multicentric squamous cell carcinoma in situ: 12 cases (2002-2005)

Veterinary and Comparative Oncology

Volumn 6, Issue 1, 2008, Pages 55-64

  Gill, Virginia L ^a   Bergman, P J ^a   Baer, K E ^a   Craft, D ^a   Leung, C ^a  

^a ANIMAL MEDICAL CENTER   (United States)

Author keywords

Bowen's disease; Cancer; Feline; Imiquimod 5 cream (Aldara ); Immune response modifier (IRM); Papillomavirus

Indexed keywords

FELIDAE; PAPILLOMAVIRIDAE;

AMINOQUINOLINE DERIVATIVE; ANTINEOPLASTIC AGENT; IMIQUIMOD;

ANIMAL; ANIMAL DISEASE; ARTICLE; BOWEN DISEASE; CARCINOMA IN SITU; CAT; CAT DISEASE; FEMALE; KAPLAN MEIER METHOD; MALE; MORTALITY; SKIN TUMOR; SQUAMOUS CELL CARCINOMA; TREATMENT OUTCOME; TUMOR RECURRENCE;

AMINOQUINOLINES; ANIMALS; ANTINEOPLASTIC AGENTS; BOWEN'S DISEASE; CARCINOMA IN SITU; CARCINOMA, SQUAMOUS CELL; CAT DISEASES; CATS; FEMALE; KAPLAN-MEIERS ESTIMATE; MALE; NEOPLASM RECURRENCE, LOCAL; SKIN NEOPLASMS; TREATMENT OUTCOME;

EID: 43149100494     PISSN: 14765810     EISSN: 14765829     Source Type: Journal    
DOI: 10.1111/j.1476-5829.2007.00144.x     Document Type: Article

References (28)

1. Baer KE and Helton K. Multicentric squamous cell carcinoma in situ resembling Bowen's disease in cats. Veterinary Pathology 1993; 30: 535-543.
2. Vail DM and Withrow SJ. Tumors of the skin and subcutaneous tissues. In: Withrow & MacEwen's Small Animal Clinical Oncology, 4th edn., SJ Withrow and DM Vail, eds., New York, Saunders Elsevier, 2007: 375-401.
3. Cox NH, Eedy DJ and Morton CA. Guidelines for management of Bowen's disease. British Journal of Dermatology 1999; 141: 633-641.
4. Cox NH, Eedy DJ and Morton CA. Guidelines for management of Bowen's disease; 2006 update. British Journal of Dermatology 2007; 156: 11-21.
5. Collina G, Rossi E, Bettelli S, Cook MG, Cesinaro AM and Trentini GP. Detection of human papillomavirus in extragenital Bowen's disease using in situ hybridization and polymerase chain reaction. American Journal of Dermatopathology 1995; 17: 236-241.
6. Zheng S, Adachi A, Shimizu M, Shibata S-I, Yasue S, Sakakibara A, Sugiura M, Nagasaka T and Tomita Y. Human papillomaviruses of the mucosal type are present in some cases of extragenital Bowen's disease. British Journal of Dermatology 2005; 152: 1243-1247.
7. Quéreaux G, N'Guyen JM and Dreno B. Human papillomavirus and extragenital in situ carcinoma. Dermatology 2004; 209: 40-45.
8. LeClerc SM, Clark EG and Haines DM. Papillomavirus infection in association with feline cutaneous squamous cell carcinoma in situ [Abstract]. Proceedings of American Association of Veterinary Dermatology/American College Veterinary Dermatology 1997; 13: 125-126.
9. Salasche S and Shumack S. A review of imiquimod 5% cream for the treatment of various dermatological conditions. Clinical and Experimental Dermatology 2003; 28(Suppl. 1): 1-3.
10. Mackenzie-Wood A, de Kossard S, Launey J, Wilkinson B and Owens ML. Imiquimod 5% cream in the treatment of Bowen's disease. Journal of the American Academy of Dermatology 2001; 44: 462-470.
11. Tran H, Moreno G and Shumack S. Imiquimod as a dermatological therapy. Expert Opinion in Pharmacotherapy 2004; 5: 427-438.
12. Wenzel J, Uerlich M, Haller O, Bieber T and Teuting T. Enhanced type 1 interferon signaling and recruitment of chemokine receptor CXCR3-expressing lymphocytes into the skin following treatment with TLR7-agonist imiquimod. Journal of Cutaneous Pathology 2005; 32: 257-262.
13. Geisse JK, Rich P, Pandya A, Gross K, Andres K, Ginkel A and Owens M. Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: A double-blind, randomized, vehicle-controlled study. Journal of the American Academy of Dermatology 2002; 47: 390-398.
14. Chen K and Shumack S. Treatment of Bowen's disease using a cycle regimen of imiquimod 5% cream. Clinical and Experimental Dermatology 2003; 28(Suppl. 1): 10-12.
15. Aldara [package insert]. St. Paul, MN, 3M Corp, 2004.
16. Patel GK, Goodwin R, Chawla M, Laidler P, Price PE, Finlay AY and Motley RJ. Imiquimod 5% cream monotherapy for cutaneous squamous cell carcinoma in situ (Bowen's disease): A randomized, double-blind, placebo-controlled trial. Journal of American Academy of Dermatology 2006; 54: 1025-1032.
17. Ooi CG, James CL and Huilgol SC. Metastatic Bowen carcinoma. Australasian Journal of Dermatology 2006; 47: 277-280.
18. Cassarino DS, DeRienzo DP and Barr RJ. Cutaneous squamous cell carcinoma: A comprehensive clinicopathologic classification. Part two. Journal of Cutaneous Pathology 2006; 33: 261-279.
19. Cassarino DS, DeRienzo DP and Barr RJ. Cutaneous squamous cell carcinoma: A comprehensive clinicopathologic classification. Part one. Journal of Cutaneous Pathology 2006; 33: 191-206.
20. Dinehart SM, Nelson-Adesokan P, Cockerell C, Russell S and Brown R. Metastatic cutaneous squamous cell carcinoma derived from actinic keratosis. Cancer 1997; 79: 920-923.
21. Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, Verweij J, Van Glabbeke M, van Oosterom AT, Christian MC and Gwyther SG. New guidelines to evaluate the response to treatment in solid tumors. Journal of the National Cancer Institute 2000; 92: 205-216.
22. Miller AB, Hoogstraten B, Staquet M and Winkler A. Reporting results of cancer therapy. Cancer 1981; 47: 207-214.
23. Goldstein D, Hertzog P and Tomkinson E. Administration of imiquimod, an interferon inducer in asymptomatic human immunodeficiency virus-infected persons to determine safety and biologic response modifications. Journal of Infectious Diseases 1998; 178: 858-861.
24. Sundberg JP, Van Ranst MV, Montali R, Homer BL, Miller WH, Rowland PH, Scott DW, England JJ, Dunstan RW, Mikaelian and Jenson AB. Feline papillomas and papillomaviruses. Veterinary Pathology 2000; 37: 1-10.
25. Carney HC, Englund JJ, Hodgin EC, Whiteley HE, Adkison DL and Sundberg JP. Papillomavirus infection in aged Persian cats. Journal of Veterinary Diagnostic Investigation 1990; 2: 294-299.
26. Wilhelm S, Degorce-Rubiales F, Godson D and Favrot C. Clinical, histological and immunohistochemical study of feline viral plaques and bowenoid in situ carcinomas. Veterinary Dermatology 2006; 17: 424-431.
27. Sato S, Okagaki T, Clark BA, Twiggs LB, Fukushima M, Ostrow RS and Faras AJ. Sensitivity of koilocytosis, immunocytochemistry, and electron microscopy as compared to DNA hybridization in detecting human papillomavirus in cervical and vaginal condyloma and intraepithelial neoplasia. International Journal of Gynecological Pathology 1986; 5: 297-307.
28. Nespeca G, Grest P, Rosenkrantz WS, Ackermann M and Favrot C. Detection of novel papillomaviruslike sequences in paraffin-embedded specimens of invasive and in situ squamous cell carcinomas from cats. American Journal of Veterinary Research 2006; 67: 2036-2041.