Therapeutic and prophylactic efficacy of aminocandin (IP960) against disseminated candidiasis in mice

Clinical Microbiology and Infection

Volumn 14, Issue 6, 2008, Pages 595-600

  Najvar, L K ^a   Bocanegra, R ^a   Wiederhold, N P ^a,b   Lambros, C ^c   Najarian, N ^d   Patterson, T F ^a   Graybill, J R ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d Indevus Pharmaceuticals   (United States)

Author keywords

Aminocandin; Antifungal prophylaxis; Candida albicans; Extended interval dosing; Invasive candidiasis; Mouse model

Indexed keywords

AMINOCANDIN; CASPOFUNGIN; ECHINOCANDIN; MANNITOL; PLACEBO;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG EFFICACY; FUNGICIDAL ACTIVITY; KIDNEY PARENCHYMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; SINGLE DRUG DOSE; SURVIVAL;

CANDIDA ALBICANS; MURINAE; MUS;

EID: 43149084819     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/j.1469-0691.2008.01994.x     Document Type: Article

References (18)

1. NP Wiederhold RE Lewis The echinocandin antifungals: an overview of the pharmacology, spectrum and clinical efficacy Expert Opin Investig Drugs 12 2003 1313 1333
2. J Mora-Duarte R Betts C Rotstein Comparison of caspofungin and amphotericin B for invasive candidiasis N Engl J Med 347 2002 2020 2029
3. ER Kuse P Chetchotisakd CA da Cunha Micafungin versus liposomal amphotericin B for candidaemia and invasive candidosis: a phase iii randomised double-blind trial Lancet 369 2007 1519 1527
4. AC Reboli C Rotstein PG Pappas Anidulafungin versus fluconazole for invasive candidiasis N Engl J Med 356 2007 2472 2482
5. J Hiemenz P Cagnoni D Simpson Pharmacokinetic and maximum tolerated dose study of micafungin in combination with fluconazole versus fluconazole alone for prophylaxis of fungal infections in adult patients undergoing a bone marrow or peripheral stem cell transplant Antimicrob Agents Chemother 49 2005 1331 1336
6. B Sirohi RL Powles R Chopra A study to determine the safety profile and maximum tolerated dose of micafungin (FK463) in patients undergoing haematopoietic stem cell transplantation Bone Marrow Transplant 38 2006 47 51
7. PA Warn A Sharp G Morrissey DW Denning Activity of aminocandin (IP960) compared with amphotericin B and fluconazole in a neutropenic murine model of disseminated infection caused by a fluconazole-resistant strain of Candida tropicalis J Antimicrob Chemother 56 2005 590 593
8. MA Ghannoum HG Kim L Long Efficacy of aminocandin in the treatment of immunocompetent mice with haematogenously disseminated fluconazole-resistant candidiasis J Antimicrob Chemother 59 2007 556 559
9. T Gumbo GL Drusano W Liu Once-weekly micafungin therapy is as effective as daily therapy for disseminated candidiasis in mice with persistent neutropenia Antimicrob Agents Chemother 51 2007 968 974
10. T Gumbo GL Drusano W Liu Anidulafungin pharmacokinetics and microbial response in neutropenic mice with disseminated candidiasis Antimicrob Agents Chemother 50 2006 3695 3700
11. A Louie M Deziel W Liu MF Drusano T Gumbo GL Drusano Pharmacodynamics of caspofungin in a murine model of systemic candidiasis: importance of persistence of caspofungin in tissues to understanding drug activity Antimicrob Agents Chemother 49 2005 5058 5068
12. National Committee for Clinical Laboratory Standards Reference method for broth dilution antifungal susceptibility testing of yeasts , approved standard, 2nd edn., M27-A2 2002 NCCLS Wayne, PA
13. D Andes K Marchillo J Lowther A Bryskier T Stamstad R Conklin In vivo pharmacodynamics of HMR 3270, a glucan synthase inhibitor, in a murine candidiasis model Antimicrob Agents Chemother 47 2003 1187 1192
14. AM Rentz MT Halpern R Bowden The impact of candidemia on length of hospital stay, outcome, and overall cost of illness Clin Infect Dis 27 1998 781 788
15. G Leleu P Aegerter B Guidet Systemic candidiasis in intensive care units: a multicenter, matched-cohort study J Crit Care 17 2002 168 175
16. JA van Burik V Ratanatharathorn DE Stepan Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation Clin Infect Dis 39 2004 1407 1416
17. NP Wiederhold DP Kontoyiannis J Chi RA Prince VH Tam RE Lewis Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: evidence of concentration-dependent activity J Infect Dis 190 2004 1464 1471
18. JR Graybill LK Najvar MF Luther AW Fothergill Treatment of murine disseminated candidiasis with l-743,872 Antimicrob Agents Chemother 41 1997 1775 1777