"Negative vaccination" by specific CD4+ T cell tolerisation enhances virus-specific protective antibody responses

PLoS ONE

Volumn 2, Issue 11, 2007, Pages

  Lang, Karl S ^a   Hegazy, Ahmed N ^a,b   Lang, Philipp A ^a   Eschli, Bruno ^a   Löhning, Max ^a,c   Hengartner, Hans ^a   Zinkernagel, Rolf M ^a   Recher, Mike ^a,d  

^a INSTITUTE OF EXPERIMENTAL IMMUNOLOGY   (Switzerland)

^b DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d University Hospital Bruderholz   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; FREUND ADJUVANT; IMMUNOGLOBULIN G ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NEUTRALIZING ANTIBODY; PEPTIDE; VIRUS ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE ACTIVATED CELL SORTING; HELPER CELL; IMMUNOREACTIVITY; IN VIVO STUDY; LYMPHOCYTE DEPLETION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; VACCINATION; VIRUS INFECTION; VIRUS MUTANT; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL SEPARATION; FLOW CYTOMETRY; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; MOLECULAR GENETICS; SERODIAGNOSIS;

LYMPHOCYTIC CHORIOMENINGITIS VIRUS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNE TOLERANCE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS;

EID: 43149083651     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001162     Document Type: Article

References (36)

1. Ada G (2001) Vaccines and Vaccination. N Engl J Med 345: 1042-53.
2. Koff WC, Johnson PR, Watkins DI, Burton DR, Lifson JD, et al. (2006) Hiv Vaccine Design: Insights from Live Attenuated Siv Vaccines. Nat Immunol 7: 19-23.
3. Inchauspe G, Feinstone S (2003) Developmett of a Hepatitis C Virus Vaccine. Clin Liver Dis 7: 243-59, xi.
4. Mullen GE, Giersing BK, Ajose-Popoola O, Davis HL, Kothe C, et al. (2006) Enhancement of Functional Antibody Responses to Amal-Cl/ Alhydrogel((R)), a Plasmodium Falciparum Malaria Vaccine, with Cpg Oligodeoxynucleotide. Vaccine 24: 2497-505.
5. von Reyn CF (2005) Tuberculosis Vaccine Trials. Lancet Infect Dis 5: 132.
6. Cohen J (1993) Jitters Jeopardize Aids Vaccine Trials. Science 262: 980-1.
7. Cao Y, Qin L, Zhang L, Safrit J, Ho DD (1995) Virologic and Immunologic Characterization of Long-Term Survivors of Human Immunodeficiency Virus Type 1 Infection. N Engl J Med 332: 201-8.
8. Pinschewer DD, Perez M, Jeetendra E, Bachi T, Horvath E, et al. (2004) Kinetics of Protective Antibodies Are Determined by the Viral Surface Antigen. J Clin Invest 114: 988-93.
9. Ciurea A, Klenerman P, Hunziker L, Horvath E, Senn BM, et al. (2000) Viral Persistence in Vivo through Selection of Neutralizing Antibody-Escape Variants. Proc Natl Acad Sci U S A 97: 2749-54.
10. Moskophidis D, Pircher H, Ciernik I, Odermatt B, Hengartner H, et al. (1992) Suppression of Virus-Specific Antibody Production by Cd8+ Class I-Restricted Antiviral Cytotoxic T Cells in Vivo. J Virol 66: 3661-8.
11. Rosa D, Saletti G, De Gregorio E, Zorat F, Comar C, et al. (2005) Activation of Naive B Lymphocytes Via Cd81, a Pathogenetic Mechanism for Hepatitis C Virus-Associated B Lymphocyte Disorders. Proc Natl Acad Sci U S A 102, 18544-9.
12. Do Milito A, Nilsson A, Titanji K, Thorstensson R, Reizenstein E, et al. (2004) Mechanisms of Hypergammaglobulinemia and Impaired Antigen-Specific Humoral Immunity in Hiv-1 Infection. Blood 103: 2180-6.
13. Hunziker L, Recher M, Macpherson AJ, Ciurea A, Freigang S, et al. (2003) Hypergammaglobulinemia and Autoantibody Induction Mechanisms in Viral Infections. Nat Immunol 4: 343-9.
14. Recher M, Lang KS, Hunziker L, Freigang S, Eschli B, et al. (2004) Deliberate Removal of T Cell Help Improves Virus-Neutralizing Antibody Production. Nat Immunol 5: 934-42.
15. Matter M, Odermatt B, Yagita H, Nuoffer JM, Ochsenbein AF (2006) Elimination of Chronic Viral Infection by Blocking Cd27 Signaling. J Exp Med 203: 2145-55.
16. Moskophidis D, Lechner F, Pircher H, Zinkernagel RM (1993) Virus Persistence in Acutely Infected Immunocompetent Mice by Exhaustion of Antiviral Cytotoxic Effector T Cells. Nature 362: 758-61.
17. Lang KS, Recher M, Navarini AA, Harris NL, Lohning M, et al. (2005) Inverse Correlation between Il-7 Receptor Expression and Cd8 T Cell Exhaustion During Persistent Antigen Stimulation. Eur J Immunol 35: 738-45.
18. Marusic S, Tonegawa S (1997) Tolerance Induction and Autoimmune Encephalomyelitis Amelioration after Administration of Myelin Basic Protein-Derived Peptide. J Exp Med 186: 507-15.
19. Zha Y, Marks R, Ho AW, Peterson AC, Janardhan S, et al. (2006) T Cell Anergy Is Reversed by Active Ras and Is Regulated by Diacylglycerol Kinase-Alpha. Nat Immunol 7: 1166-73.
20. Unsoeld H, Krautwald S, Vochringer D, Kunzendorf U, Pircher H (2002) Cutting Edge: Ccr7+ and Ccr7- Memory T Cells Do Not Differ in Immediate Effector Cell Function. J Immunol 169: 638-41.
21. Sallusto F, Mackay CR, Lanzavecchia A (2000) The Role of Chemokine Receptors in Primary, Effector, and Memory Immune Responses. Annu Rev Immunol 18: 593-620.
22. Swain SL, Agrewala JN, Brown DM, Jelley-Gibbs DM, Golech S, et al. (2006) Cd4+ T-Cell Memory: Generation and Multi-Faceted Roles for Cd4+ T Cells in Protective Immunity to Influenza. Immunol Rev 211: 8-22.
23. Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, et al. (2006) Pd-1 Expression on Hiv-Specific T Cells Is Associated with T-Cell Exhaustion and Disease Progression. Nature 443: 350-4.
24. Eschli B, Zellweger R, Wepf A, Lang KS, Quirin K, et al. (2007) Early Antibodies Specific for the Neutralizing Epitope on the Receptor Binding Subunit of the Lymphocytic Choriomeningitis Virus Glycoprotein Fail to Neutralize the Virus. J Virol.
25. Janssen EM, Lemmens EE, Wolfe T, Christen U, von Herrath MG, et al. (2003) Cd4+ T Cells Are Required for Secondary Expansion and Memory in Cd8+ T Lymphocytes. Nature 421: 852-6.
26. Sun JC, Bevan MJ (2003) Defective Cd8 T Cell Memory Following Acute Infection without Cd4 T Cell Help. Science 300: 339-42.
27. Shedlock DJ, Shen H (2003) Requirement for Cd4 T Cell Help in Generating Functional Cd8 T Cell Memory. Science 300: 337-9.
28. Lehmann-Grube F, Lohler J, Utermohlen O, Gegin C (1993) Antiviral Immune Responses of Lymphocytic Choriomeningitis Virus-Infected Mice Lacking Cd8+ T Lymphocytes Because of Disruption of the Beta 2-Microglobulin Gene. J Virol 67: 332-9.
29. Brundler MA, Aichele P, Bachmann M, Kitamura D, Rajewsky K, et al. (1996) Immunity to Viruses in B Cell-Deficient Mice: Influence of Antibodies on Virus Persistence and on T Cell Memory. Eur J Immunol 26: 2257-62.
30. Aichele P, Brduscha-Riem K, Zinkernagel RM, Hengartner H, Pircher H (1995) T Cell Priming Versus T Cell Tolerance Induced by Synthetic Peptides. J Exp Med 182: 261-6.
31. Sun JC, Williams MA, Bevan MJ (2004) Cd4+ T Cells Are Required for the Maintenance, Not Programming, of Memory Cd8+ T Cells after Acute Infection. Nat Immunol 5: 927-33.
32. Kaplan DE, Sugimoto K, Newton K, Valiga ME, Ikeda F, et al. (2007) Discordant Role of Cd4 T-Cell Response Relative to Neutralizing Antibody and Cd8 T-Cell Responses in Acute Hepatitis C. Gastroenterology 132: 654-66.
33. Meyer MF, Lehmann M, Cornberg M, Wiegand J, Manns MP, et al. (2007) Clearance of Low Levels of Hcv Viremia in the Absence of a Strong Adaptive Immune Response. Virol J 4: 58.
34. Thomson M, Nascimbeni M, Havert MB, Major M, Gonzales S, et al. (2003) The Clearance of Hepatitis C Virus Infection in Chimpanzees May Not Necessarily Correlate with the Appearance of Acquired Immunity. J Virol 77: 862-70.
35. Staprans SI, Barry AP, Silvestri G, Safrit JT, Kozyr N, et al. (2004.) Enhanced Siv Replication and Accelerated Progression to Aids in Macaques Primed to Mount a Cd4 T Cell Response to the Siv Envelope Protein. Proc Natl Acad Sci U S A 101: 13026-31.
36. Hazenberg MD, Otto SA, van Benthem BH, Roos MT, Coutinho RA, et al. (2003) Persistent Immune Activation in Hiv-1 Infection Is Associated with Progression to Aids. Aids 17: 1881-8.