The Inhalation toxicity of di- and triethanolamine upon repeated exposure

Food and Chemical Toxicology

Volumn 46, Issue 6, 2008, Pages 2173-2183

  Gamer, A O ^a   Rossbacher, R ^a   Kaufmann, W ^a   van Ravenzwaay, B ^a  

^a BASF SE   (Germany)

Author keywords

Diethanolamine; Inhalation; Irritation; Neurotoxicity; Respiratory tract; Triethanolamine

Indexed keywords

DIETHANOLAMINE; TRIETHANOLAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD TOXICITY; BODY WEIGHT; CHEMICAL STRUCTURE; CONTROLLED STUDY; EPIGLOTTIS; FEMALE; HISTOPATHOLOGY; LARYNX MUCOSA; LIVER TOXICITY; MALE; METAPLASIA; NEPHROTOXICITY; NEUROTOXICITY; NONHUMAN; ORGAN WEIGHT; RAT; TESTIS DISEASE; TRACHEA; UPPER RESPIRATORY TRACT INFECTION;

ANIMALS; BLOOD CELL COUNT; EPITHELIUM; ERYTHROCYTE COUNT; ETHANOLAMINES; FEMALE; INHALATION EXPOSURE; IRRITANTS; LARYNX; MALE; NEUROTOXICITY SYNDROMES; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RATS; RATS, WISTAR; RESPIRATORY SYSTEM; URINALYSIS;

ANIMALIA; RATTUS NORVEGICUS;

EID: 43049175036     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.02.020     Document Type: Article

References (53)

1. Anon. Final report on the safety assessment of triethanolamine, diethanolamine, and monoethanolamine. J. Am. Coll. Toxicol. 2 (1983) 183-235
2. Barbee S.J., and Hartung R. The effect of diethanolamine on hepatic and renal phospholipid metabolism in the rat. Toxicol. Appl. Pharmacol. 47 (1979) 421-430
3. Barbee S.J., and Hartung R. Diethanolamine-induced alteration of hepatic mitochondrial function and structure. Toxicol. Appl. Pharmacol. 47 (1979) 431-440
4. BG-Chemie, Berufsgenossenschaft der chemischen Industrie, 1990a. Toxikologische Bewertung Diethanolamin (No. 158). BG Chemie, Heidelberg.
5. BG-Chemie, Berufsgenossenschaft der chemischen Industrie, 1990b. Toxikologische Bewertung Triethanolamin (No. 57). BG Chemie, Heidelberg.
6. BIBRA, The British Industrial Biological Research Association, 1990. Toxicity profile triethanolamine. BIBRA Toxicology International, Great Britain.
7. BIBRA, The British Industrial Biological Research Association, 1993. Toxicity Profile Diethanolamine. BIBRA Toxicology International, Great Britain.
8. Blum K., Huizenga C.G., Ryback R.S., Johnson D.K., and Geller I. Toxicity of diethanolamine in mice. Toxicol. Appl. Pharmacol. 22 (1972) 175-185
9. Burger G.T., Renne R.A., Sagartz J.W., Ayres P.H., Coggins C.R.E., Mosberg A.T., and Hayes A.W. Histologic changes in the respiratory tract induced by inhalation of xenobiotics: physiologic adaption or toxicity. Toxicol. Appl. Pharmacol. 101 (1989) 521-542
10. Cochran W. Anova (analysis of covariance): its nature and uses. Biometrics 8 (1957) 261-278
11. Dungworth, D.L., Rittinghausen, S., Schwartz, L., Harkema, J.R., Hayashi, Y., Kittel, B., Lewis, D., Miller, R.A., Mohr, U., Morgan, K.T., Rehm, S., Slayter, M.V., 2001, Respiratory system and mesothelium. In: International Classification of Rodent Tumors. The mouse. Mohr, U., Capen, C.C., Dungworth, D.L., Greaves, P., Hardisty, J.F., Hayashi, Y., Ito, N., Long, P.H., Krinke, G., (Eds.) Springer, Berlin, Heidelberg, New York, pp. 87-137.
12. Dunnett C.W. A multiple comparison procedure for comparing several treatments with a control. J. Am. Stat. Assoc. 50 (1955) 1096-1121
13. Dunnett C.W. New tables for multiple comparisons with a control. Biometrics 20 (1964) 482-491
14. EEC, European Economic Community, 1988. Commission Directive 87/302/EEC, "Sub-Chronic Inhalation Toxicity Study", published in the Official J. Eur. Communities L133, 05/30/1988.
15. EPA, Environmental Protection Agency, 1985. Guideline "Functional Observational Battery", "Motor Activity", and "Neuropathology". Federal Register 50, pp. 39458-39463.
16. EPA, Environmental Protection Agency, 1987. Guideline "Functional Observational Battery", "Motor Activity", and "Neuropathology". Federal Register 97, pp. 19081-19082.
17. EPA, Environmental Protection Agency, 1998. Health effects test guidelines OPPTS 870.3465, 90-Day Inhalation Toxicity, EPA Document 712-C-98-204, August 1998.
18. ESTP: 1st International expert workshop: "larynx squamous metaplasia": A re-consideration of morphology and meaning in rodent studies and its relevance for humans. Final minutes, 2007. .
19. Fischer M., and Falkensammer C. Hepato-quick - a new thromboplastin time system: a comparison with normotest and thrombotest. Wiener Klinische Wochenschrift 86 (1974) 577-583
20. Hartung R., Rigas L.K., and Cornish H.H. Acute and chronic toxicity of diethanolamine. Toxicol. Appl. Pharmacol. 17 (1970) 308
21. Hettmansperger T.P. Statistical Inference Based on Ranks (1984), John Wiley & Sons, New York 132-140
22. Kalberlah, F., Schneider, K., Schuhmacher, U.S., Voss, J.U., Ioannidis, I., Oltmanns, J., 1999. Zeitextrapolation und Interspeziesextrapolation bei lokal wirksamen Stoffen mit begrenzter Datenlage. Schriftenreihe der Bundesanstalt für Arbeitsschutz und Arbeitsmedizin, Fb 862. Wirtschaftsverlag NW, Bremerhaven.
23. Knaak J.B., Leung H.W., Stott W.T., Busch J., and Bilsky J. Toxicology of mono-, di-, and triethanolamine. Rev. Environ. Contamin. Toxicol. 149 (1997) 1-86
24. Kohri N., Matsuda T., Umeniwa K., Miyazaki K., and Arita T. Development of assay method in biological fluids and biological fate of triethanolamine. Yakuzaigaku 42 (1982) 342-348
25. Lundberg, P., 1992. Scientific Basis for Swedish Occupational Standards XIII. Arbete och Hälsa 47. Arbetsmiljöinstitutet, Solna, Sweden.
26. MAK, 2001a. Diethanolamine amendment 2001 in Gesundheitsschädliche Arbeitsstoffe. Wiley-VCH Verlag GmbH&Co. KgaA.
27. MAK, 2001b. Triethanolamine Sensibilisierende Wirkung in Gesundheitsschädliche Arbeitsstoffe. Wiley-VCH Verlag GmbH&Co. KgaA.
28. MAK, 2007. Triethanolamine Sensibilisierende Wirkung (2006) in Gesundheitsschädliche Arbeitsstoffe. Wiley-VCH Verlag GmbH&Co. KgaA.
29. Mathews J.M., Garner C.E., and Matthews H.B. Metabolism, bioaccumulation, and incorporation of diethanolamine into phospholipids. Chem. Res. Toxicol. 8 (1995) 625-633
30. Mathews J.M., Garner C.E., Black S.L., and Matthews H.B. Diethanolamine absorption, metabolism and disposition in rat and mouse following oral, intravenous and dermal administration. Xenobiotica 27 (1997) 733-746
31. Melnick R.L., Mahler J., Bucher J.R., Thompson M., Hejtmancik M., Ryan M.J., and Mezza L.E. Toxicity of diethanolamine. 1. Drinking water and topical application exposures in F344 rats. J. Appl. Toxicol. 14 1 (1994) 1-9
32. Mendrala A.L., Waechter J.M., Bormett G.A., Bartels M.J., and Stott W.T. The pharmacokinetics of diethanolamine in Sprague-Dawley rats following intravenous administration. Food Chem. Toxicol. 39 (2001) 931-939
33. Miller R.G. Simultaneous Statistical Inference (1981), Springer-Verlag, New York 165-167
34. Mosberg, A., McNeill, D., Hejtmancik, M., Persing, R. L., Peters, A., 1985a. Final Report on the Repeated Dose Inhalation Study of Triethanolamine in Fischer 344 Rats to National Toxicology Program. BATTELLE Columbus Laboratories, Columbus, OH.
35. Mosberg, A., McNeill, D., Hejtmancik, M., Persing, R. L., Peters, A., 1985b. Final Report on the Repeated Dose Inhalation Study of Triethanolamine in B6C3F1 Mice to National Toxicology Program. BATTELLE Columbus Laboratories, Columbus, OH.
36. Nijenhuis A., and Wilf S.W. Combinatorial Algorithms (1978), Academic Press, New York 32-33
37. NLM, U.S. National Library of Medicine, 2004. HSDB, Hazardous Substances Databank. .
38. NTP, National Toxicology Program, 1992. Toxicity Studies of diethanolamine administered topically and in drinking water to F344/N rats and B6C3F1 mice. Toxicity Reports Series 20. U.S. Department of Health and Human Services, Public Health Service.
39. NTP, National Toxicology Program, 1999a. Toxicology and carcinogenesis studies of diethanolamine in F344/N rats and B6C3F1 mice (dermal studies). TR 478. U.S. Department of Health and Human Services; Public Health Service.
40. NTP, National Toxicology Program, 1999b. Toxicology and carcinogenesis studies of triethanolamine in F344/N rats and B6C3F1 mice (dermal studies). TR 449. U.S. Department of Health and Human Services; Public Health Service.
41. NTP, National Toxicity Program, 2005. The immunotoxicity of triethanolamine (CAS No. 102-71-6) contact hypersensitivity studies in female B6C3F1 mice NTP report number: IMM90005.
42. OECD, 1981a. Guideline for Testing of Chemicals No. 412 "Repeated Dose Inhalation Toxicity: 28-day or 14-day Study". Section 4: Health Effects. Paris, France. ISBN: 92-64-12221-4.
43. OECD, 1981b. Guideline for Testing of Chemicals No. 413 "Sub-chronic Inhalation Toxicity: 90-day Study". Section 4: Health Effects. Paris, France. ISBN: 92-64-12221-4.
44. Osimitz T.G., Droege W., and Finch J.M. Toxicologic significance of histologic change in the larynx of the rat following inhalation exposure: a critical review. Toxicol. Appl. Pharmacol. 225 (2007) 229-237
45. Pors, J., Fuhlendorff, R., 2002. Mapping of Chemical substances from sanitary towels. Survey of Chemical Substances in Consumer Products, Survey No. 13. Danish Environmental Protection Agency.
46. Research and Consulting Co.AG (RCC), 1990. Contact hypersensitivity to diethanolamin, rein, in albino guinea pigs, Maximization Test; RCC-Project 264903, 05-10-1990. Unpublished. Report performed on behalf of BG Chemie, Heidelberg, FRG.
47. Sagartz J.W., Madarasz A.J., Forsell M.A., Burger G.T., Ayres P.H., and Coggins R.E. Histological sectioning of the rodent larynx for inhalation toxicity testing. Toxicol. Pathol. 20 (1992) 118-121
48. Schermer S. The Blood Morphology of Laboratory Animals (1967), F.A. Davis Co, Philadelphia
49. Siegel S. Non-parametric Statistics for the Behavioural Sciences (1956), McGraw-Hill, New York
50. Snipes M.B. Long-term retention and clearance of particles inhaled by mammalian species. Crit. Rev. Toxicol. 20 3 (1989) 175-211
51. Stott W.T., Waechter J.M., Rick D.L., and Mandrala A.L. Absorption, distribution, metabolism and excretion of intravenously and dermally administered triethanolamine in mice. Food Chem. Toxicol. 38 (2000) 1043-1051
52. Winer B.J. Statistical principals in experimental design. second ed. (1971), McGraw-Hill, New York
53. Zeile, G., Baake, M., Henrici, G., 1980. Kompendium der praktischen Hämatologie (Compendium of Practical Hematology), GIT Verlag Ernst Giebler, Darmstadt, Germany, p. 196.