Synthesis of gemcitabine triphosphate (dFdCTP) as a tris(triethylammonium) salt

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 9, 2008, Pages 2957-2958

  Risbood, Prabhakar A ^a   Kane Jr , Charles T ^b   Hossain, Md Tafazzal ^b   Vadapalli, Sudhakarrao ^b   Chadda, Satish K ^b  

^a Developmental Therapeutics Program   (United States)

^b Starks Associates Inc   (United States)

Author keywords

Gemcitabine triphosphate (dFdCTP)

Indexed keywords

AMMONIUM DERIVATIVE; GEMCITABINE TRIPHOSPHATE;

ARTICLE; DRUG PURIFICATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; ROOM TEMPERATURE; THIN LAYER CHROMATOGRAPHY;

ANTIMETABOLITES, ANTINEOPLASTIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; DEOXYCYTIDINE; HUMANS; MODELS, CHEMICAL; POLYPHOSPHATES; QUATERNARY AMMONIUM COMPOUNDS; SALTS; TROMETHAMINE; TUMOR CELLS, CULTURED;

EID: 43049150798     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.063     Document Type: Article

References (5)

1. Norenberg, J. P. U.S. Patent 20070025910, 2007; Chem. Abstr. 2007, 146, 200935.
2. The following reference describes an assay of dFdCTP:. Veltkamp S.A., Hillebrand M.J.X., Rosing H., Jansen R.S., Wickremsinha E.R., Perkins E.J., Schellens J.H.M., and Beijnen J.H. J. Mass Spectrom. 41 (2006) 1633 This reference describes obtaining dFdCTP from Eli Lilly and Company; however, the method of synthesis or isolation was not indicated.
3. Burgess K., and Cook D. Chem. Rev. 100 (2000) 2047
4. Bogachev V.S. Russ. J. Bioorg. Chem. 22 (1996) 599
5. Bonjouklian, R.; Grindey, G. B.; Hertel, L. W. European Patent Application 0376518, 1990; Chem. Abstr. 1991, 114, 43489.