Pseudohypericin and hyperforin in Hypericum perforatum from Northern Turkey: Variation among populations, plant parts and phenological stages

Journal of Integrative Plant Biology

Volumn 50, Issue 5, 2008, Pages 575-580

  Çirak, Cüneyt ^a   Radusiene, Jolita ^b   Janulis, Valdimaras ^c   Ivanauskas, Liudas ^c  

^a ONDOKUZ MAYIS UNIVERSITY   (Turkey)

^b INSTITUTE OF BOTANY   (Lithuania)

^c KAUNAS UNIVERSITY OF MEDICINE   (Lithuania)

Author keywords

Hyperforin; Hypericum perforatum; Population variability; Porphologic and phenologic variations; Pseudohypericin

Indexed keywords

BICYCLO COMPOUND; DRUG DERIVATIVE; HYPERFORIN; PERYLENE; PHLOROGLUCINOL; PSEUDOHYPERICIN; TERPENE;

LIQUID CHROMATOGRAPHY; MEDICINAL PLANT; METABOLITE; MORPHOLOGY; PERENNIAL PLANT; PHENOLOGY; POPULATION DYNAMICS;

ARTICLE; CHEMISTRY; CLIMATE; GEOGRAPHY; GROWTH, DEVELOPMENT AND AGING; HYPERICUM; PLANT; PLANT LEAF; PLANT STEM; POPULATION DYNAMICS; SEASON; TURKEY (REPUBLIC);

BICYCLO COMPOUNDS; CLIMATE; GEOGRAPHY; HYPERICUM; PERYLENE; PHLOROGLUCINOL; PLANT COMPONENTS; PLANT LEAVES; PLANT STEMS; POPULATION DYNAMICS; SEASONS; TERPENES; TURKEY;

EURASIA; TURKEY;

HYPERICUM PERFORATUM;

EID: 43049117563     PISSN: 16729072     EISSN: 17447909     Source Type: Journal    
DOI: 10.1111/j.1744-7909.2008.00657.x     Document Type: Article

References (33)

1. Abreu IN, Porto ALM, Marsaioli AJ, Mazzafera P (2004). Distrubution of bioactive substances from Hypericum brasiliense during plant growth. Plant Sci. 167, 949-954.
2. Ayan AK, Çirak C, Yanar O (2006). Variations in total phenolics during ontogenetic, morphogenetic, and diurnal cycles in Hypericum species from Turkey. J. Plant Biol. 49, 432-440.
3. Anon. (2004). St. John's wort dry extract, quantified. Pharmeuropa 16, 97-98.
4. Bergonzi MC, Bilia AR, Gallori S, Guerrini D, Vincieri FF (2001). Variability in the content of the constituents of Hypericum perforatum L. and some commercial extracts. Drug Dev. Ind. Pharm. 27, 491-497.
5. Büter KB, Büter B (2002). Ontogenetic variation regarding hypericin and hyperforin levels in four accessions of Hypericum perforatum L. J. Herbs Species Med. Plants 9, 95-100.
6. Cameron DW, Raverty WD (1976). Pseudohypericin and other phenanthroperilene quinones. Aust. J. Chem. 29, 1523-1533.
7. Ciccarelli D, Andreucci AC, Pagni AM (2001). Translucent glands and secretory canals in Hypericum perforatum, morphological, anatomical and histochemical studies during the course of onthogenesis. Ann. Bot. Lond. 88, 637-644.
8. Çirak C, Radušiene J, Sàlam B, Janulis V (2007a). Variation of bioactive substances and morphological traits in Hypericum perforatum populations from Northern Turkey. Biochem. Syst. Ecol. 35, 403-409.
9. Çirak C, Radušiene J, Karabük B, Janulis V, Ivanauskas L (2007b). Variation of bioactive compounds in Hypericum perforatum growing in Turkey during its phenological cycle. J. Int. Plant Biol. 49, 615-620.
10. Couceiro MA, Afreen F, Zobayed SMA, Kozai T (2006). Variation in concentrations of major bioactive compounds of St. John's wort, effects of harvesting time, temperature and germplasm. Plant Sci. 170, 128-134.
11. Dona M, Dell'Aica I, Pezzato E, Sartor L, Calabrese F, Della Barbera M et al. (2004). Hyperforin inhibits cancer invasion and metastasis. Cancer Res. 64, 6225-6232.
12. 2+ mobilization and functional leukocyte responses by hyperforin. Biochem. Pharmacol. 67, 1531-1539.
13. Greeson J, Sanford B, Monti DA (2001). St. John's wort (Hypericum perforatum L.). A review of the current pharmacological, toxicological and clinical literature. Psychopharmacology 153, 402-414.
14. Guedes RC, Eriksson LA (2005). Theoretical study of hypericin. J. Photochem. Photobiol. A. Chem. 172, 293-299.
15. Kazlauskas S, Bagdonaite E (2004). Quantitative analysis of active substances in St. John's wort (Hypericum perforatum L.) by the high performance liquid chromatography method. Medicina (Kaunas) 40, 975-981.
16. Kirakosyan A, Gibson D, Sirvent T (2003). Comperative survey of Hypericum perforatum plants as sources of hypericins and hyperforin. J. Herbs Species Med. Plants 10, 110-122.
17. Kurth H, Spreemann R (1998). Phytochemical characterisation of various St. John's wort extracts. Adv. Ther. 15, 117-128.
18. Maggi F, Ferretti G, Pocceschi N, Menghini L, Ricciutelli M (2004). Morphological, histochemical and phytochemical investigation of the genus Hypericum of the Central Italy. Fitoterapia 75, 702-711.
19. Martonfi P, Repcak M, Martonfiova L (2006). Secondary metabolites during ontogenetic phase of reproductive structures in Hypericum maculatum. Biologia 61, 473-478.
20. Medina MA, Martínez-Poveda B, Amores-Sánchez MI, Quesada AR (2006). Hyperforin. More than an antidepressant bioactive compound? Life Sci. 79, 105-111.
21. Radusiene J, Bagdonaite E, Kazlauskas S (2004). Morphological and chemical evaluation on Hypericum perforatum and H. maculatum in Lithuania. Acta Hort. (ISHS) 629, 55-62.
22. Repcak M, Mártonfi P (1997). The localization of secondary substances in Hypericum perforatum flower. Biol. Bratislava 52, 91-94.
23. Robson NKB (1981). Studies in the genus Hypericum L. (Guttiferae). 2. Characters of the genus. Bull. British Mus. (Natural History) 8, 55-226.
24. Roz N, Rehavi M (2004). Hyperforin depletes synaptic vesicles content and induces compartmental redistribution of nerve ending monoamines. Life Sci. 75, 2841-2850.
25. Sanchez-Mateo CC, Prado B, Rabanal RM (2002). Antidepressant effects of the methanol extract of several Hypericum species from the Canary Islands. J. Ethnopharmacol. 79, 119-127.
26. Schwarz D, Kisselev P, Roots I (2003). St. John's wort extracts and some of their constituents potently inhibit ultimate carcinogen formation from benzo [a]pyrene-7,8-dihydrodiol by human CYP1A1. Cancer Res. 63, 8062-8068.
27. Seidler-Lozykowska K (2003). Secondary metabolites content of Hypericum sp. in different stages and plant parts. In: Ernst E, ed. Hypericum, The Genus Hypericum. Taylor and Francis, London & New York. pp. 100-105.
28. Sirvent T (2001). Hypericins: A Family of Light-activated Anthraquinones in St. John's Wort (Hypericum perforatum L.) and Their Importance in Plant/Pathogen/Herbivore Interactions. Cornell University, Ithaca, NY. pp. 213.
29. Sirvent T, Walker L, Vance N, Gibson D (2002). Variation in hypericins from wild populations of Hypericum perforatum L. in the Pacific Northwest of the USA. Econ. Bot. 56, 41-49.
30. Southwell IA, Campbell MH (1991). Hypericin content variation in Hypericum perforatum L. in Australia. Phytochemistry 30, 475-478.
31. Upton R, Graff A, Williamson E, Bunting D, Gatherum M, Walker EB et al. (1997). St. John's Wort, Hypericum perforatum: Quality Control, Analytical and Therapeutic Monograph. American Herbal Pharmacopoeia, Santa Cruz, CA.
32. Vlietinck AJ, De Beuyne T, Apers S, Pieters L (1998). Plant derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection. Planta Med. 64, 97-109.
33. Walker L, Sirvent T, Gibson D, Vance N (2001). Regional differences in hypericin and pseudohypericin concentrations and five morphological traits among Hypericum perforatum plants in the North-western United States. Can. J. Bot. 79, 1248-1255.