Effect of controlled release of fibroblast growth factor-2 from chitosan/fucoidan micro complex-hydrogel on in vitro and in vivo vascularization

Journal of Biomedical Materials Research - Part A

Volumn 85, Issue 3, 2008, Pages 619-627

  Nakamura, Shingo ^a   Nambu, Masaki ^a   Ishizuka, Takamitsu ^a   Hattori, Hidemi ^a   Kanatani, Yasuhiro ^a   Takase, Bonpei ^a   Kishimoto, Satoko ^a   Amano, Yoshiko ^a   Aoki, Hiroshi ^b   Kiyosawa, Tomoharu ^a   Ishihara, Masayuki ^a   Maehara, Tadaaki ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b HOKKAIDO INDUSTRIAL TECHNOLOGY CENTER   (Japan)

Author keywords

Chitosan fucoidan micro complex hydrogel; Complex formation; Fibroblast growth factor 2; Stabilization; Vascularization

Indexed keywords

BIODEGRADATION; CELL GROWTH; CHITOSAN; DISEASES; HYDROGELS; STABILIZATION; TISSUE;

COMPLEX FORMATION; FIBROBLAST GROWTH FACTOR-2; FUCOIDAN MICRO COMPLEX-HYDROGEL; VASCULARIZATION;

FIBROBLASTS;

CHITOSAN; FIBROBLAST GROWTH FACTOR 2; FUCOIDIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIODEGRADABILITY; BIODEGRADATION; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DIFFUSION; HALF LIFE TIME; HEAT; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; INJECTION; ISCHEMIA; MALE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; VASCULARIZATION;

ANIMALS; CHITOSAN; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; FIBROBLAST GROWTH FACTOR 2; HALF-LIFE; HYDROGEL; ISCHEMIA; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; POLYSACCHARIDES;

EID: 43049097572     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.31563     Document Type: Article

References (22)

1. Gospodarowicz D. Fibroblast growth factor and its involvement in developmental processes. Curr Top Dev Biol 1990;24:57-93.
2. Tabata Y, Ikada Y. Vascularization effect of basic fibroblast growth factor released from gelatin hydrogels with different biodegradabilities. Biomaterials 1999;20:2169-2175.
3. Ishihara M, Ono K. Structure and function of heparin and heparan sulfate: Heparinoid library and modification of FGF-activities. Trends Glycosci Glycotechnol 1998;10:223-233.
4. Slack JM, Darlington BG, Heath JK, Godsave SF. Mesoderm induction in early Xenopus embryos by heparin binding growth factors. Nature 1987;326:197-200.
5. Canalis E, Centrella M, McCarthy T. Effects of basic fibroblast growth factor on bone formation in vitro. J Clin Invest 1988;81:1572-1577.
6. Ishihara M. Biosynthesis, structure, and biological activity of basic FGF binding domains of heparan sulfate. Trends Glycosci Glycotechnol 1993;5:343-354.
7. Lindahl U, Lidholt K, Spillmann D, Kjellen L. More to "heparin" than anti-coagulation. Thromb Res 1994;75:1-32.
8. Ishihara M, Sato M, Hattori H, Saito Y, Yura H, Ono K, Masuoka K, Kikuchi M, Fujikawa K, Kurita A. Heparin-carrying polystyrene (HCPS)-bound collagen substratum to immobilize heparin-binding growth factors and to enhance cellular growth. J Biomed Mater Res 2001;56:536-544.
9. Tanihara M, Suzuki Y, Yamamoto E, Noguchi A, Mizushima Y. Sustained release of basic fibroblast growth factor and angiogenesis in a novel covalently crosslinked gel of heparin and alginate. J Biomed Mater Res 2001;56:216-222.
10. Ishihara M, Obara K, Ishizuka T, Fujita M, Sato M, Masuoka K, Saito Y, Yura H, Matsui T, Hattori H, Kikuchi M, Kurita A. Controlled release of fibroblast growth factors and heparin from photocrosslinked chitosan hydrogels and subsequent effect on in vivo vascularization. J Biomed Mater Res A 2003;64:551-559.
11. Fujita M, Ishihara M, Shimizu M, Obara K, Ishizuka T, Saito Y, Yura H, Morimoto Y, Takase B, Matsui T, Kikuchi M, Maehara T. Vascularization in vivo caused by the controlled release of fibroblast growth factor-2 from an injectable chitosan/non-anticoagulant heparin hydrogel. Biomaterials 2004;25:699-706.
12. Shigemasa Y, Minami S. Application of chitin and chitosan for biomaterials. Biotechnol Genet Eng Rev 1995;13:383-420.
13. Ono K, Saito Y, Yura H, Ishikawa K, Kurita A, Ishihara M. Photocrosslinkable chitosan as a biological adhesive. J Biomed Mater Res 2000;49:289-295.
14. Ishihara M, Nakanishi K, Ono K, Sato M, Saito Y, Yura H, Matsui T, Hattori H, Uenoyama M, Kikuchi M, Kurita A. Photocrosslinkable chitosan as a dressing for wound occlusion and accerelator in healing process. Biomaterials 2002;23:833-840.
15. Obara K, Ishihara M, Ishizuka T, Fujita M, Ozeki Y, Maehara T, Saito Y, Yura H, Matsui T, Hattori H, Kikuchi M, Kurita A. Photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 stimulates wound healing in healing-impaired db/db mice. Biomaterials 2003;24:3437-3444.
16. Nishide E, Anzai H, Uchida N. A comparative investigation on the contents of fucose-containing polysaccharides from various Japanese brown algae. Nippon Suisan Gakkai Shi 1987;53:1083-1088.
17. Belford DA, Hendry IA, Parish CR. Investigation of the ability of several naturally occurring and synthetic polyanions to bind to and potentiate the biological activity of acidic fibroblast growth factor. J Cell Physiol 1993;157:184-189.
18. Luyt CE, Meddahi-Pelle A, Ho-Tin-Noe B, Colliec-Jouault S, Guezennec J, Louedec L, Prats H, Jacob M-P, Osborne-Pellegrin M, Letourneur D, Michel J-B. Low-molecular-weight fucoidan promotes therapeutic revascularization in a rat model of critical hindlimb ischemia. J Pharmacol Exp Ther 2003;305:24-30.
19. Masuoka K, Ishihara M, Asazuma T, Hattori H, Matsui T, Takase B, Kanatani Y, Fujita M, Saito Y, Yura H, Fujikawa K, Nemoto K. The interaction of chitosan with fibroblast growth factor-2 and its protection from inactivation. Biomaterials 2005;26:3277-3284.
20. Gospodarowicz D, Cheng J. Heparin protects basic and acidic FGF from inactivation. J Cell Physiol 1986;128:475-484.
21. Millet J, Jouault SC, Mauray S, Theveniaux J, Sternberg C, Boisson-Vidal C, Fischer AM. Antithrombotic and anticoagulant activities of a low molecular weight fucoidan. Thromb Haemost 1999;81:391-395.
22. Giraux J, Matou S, Bros A, Tapon-bretaudiere J, Letourneur D, Fischer A. Modulation of human endothelial cell proliferation and migration by fucoidan and heparin. Eur J Cell Biol 1998;77:352-359.