Linking adiponectin to proteinuria

Journal of Clinical Investigation

Volumn 118, Issue 5, 2008, Pages 1619-1622

  Ahima, Rexford S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPONECTIN; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; BIOLOGICAL MARKER; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; ROSIGLITAZONE;

AFRICAN AMERICAN; ALBUMINURIA; DISEASE ASSOCIATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ETHNIC DIFFERENCE; GLOMERULUS CAPILLARY; GLOMERULUS FILTRATION RATE; HORMONE DEFICIENCY; HUMAN; INFLAMMATION; KIDNEY BLOOD FLOW; KIDNEY DISEASE; KIDNEY FUNCTION; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NOTE; OBESITY; OXIDATIVE STRESS; PODOCYTE; PRIORITY JOURNAL; PROTEINURIA; URINARY EXCRETION;

ADIPONECTIN; AFRICAN AMERICANS; ANIMALS; BIOLOGICAL MARKERS; HUMANS; KIDNEY DISEASES; KIDNEY GLOMERULUS; MICE; MICE, KNOCKOUT; OBESITY; OXIDATIVE STRESS; PROTEINURIA;

EID: 43049097496     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI35655     Document Type: Note

References (20)

1. Ogden, C.L., Yanovski, S.Z., Carroll, M.D., and Flegal, K.M. 2007. The epidemiology of obesity. Gastroenterology. 132:2087-2102.
2. Coresh, J., et al. 2007. Prevalence of chronic kidney disease in the United States. JAMA. 298:2038-2047.
3. Kramer, H., et al. 2005. Obesity and prevalent and incident CKD: the Hypertension Detection and Follow-Up Program. Am. J. Kidney Dis. 46:587-594.
4. Locatelli, F., Pozzoni, P., and Del Vecchio, L. 2006. Renal manifestations in the metabolic syndrome. J. Am. Soc. Nephrol. 17(4 Suppl. 2):S81-S85.
5. de Zeeuw, D., Parving, H.H., and Henning, R.H. 2006. Microalbuminuria as an early marker for cardiovascular disease. J. Am. Soc. Nephrol. 17:2100-2105.
6. Wachtell, K., et al. 2003. Albuminuria and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE study. Ann. Intern. Med. 139:901-906.
7. Sharma, K., et al. 2008. Adiponectin regulates albuminuria and podocyte function in mice. J. Clin. Invest. 118:1645-1656.
8. Kadowaki, T. 2006. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J. Clin. Invest. 116:1784-1792.
9. Pajvani, U.B., et al. 2004. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J. Biol. Chem. 279:12152-12162.
10. Nawrocki, A.R., et al. 2006. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J. Biol. Chem. 281:2654-2660.
11. Yamauchi, T., et al. 2007. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat. Med. 13:332-339.
12. Ohashi, K., et al. 2007. Exacerbation of albuminuria and renal fibrosis in subtotal renal ablation model of adiponectin-knockout mice. Arterioscler. Thromb. Vasc. Biol. 27:1910-1917.
13. Ouedraogo, R., et al. 2007. Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. J. Clin. Invest. 117:1718-1726.
14. Xu, A., et al. 2003. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J. Clin. Invest. 112:91-100.
15. Nishihara, T., et al. 2006. Effect of adiponectin on murine colitis induced by dextran sulfate sodium. Gastroenterology. 131:853-861.
16. Yano, Y., et al. 2007. Differential impacts of adiponectin on low-grade albuminuria between obese and nonobese persons without diabetes. J. Clin. Hypertens. (Greenwich) 9:775-782.
17. Looker, H.C., et al. 2004. Adiponectin concentrations are influenced by renal function and diabetes duration in Pima Indians with type 2 diabetes. J. Clin. Endocrinol. Metab. 89:4010-4017.
18. Pistrosch, F., et al. 2005. Rosiglitazone improves glomerular hyperfiltration, renal endothelial dysfunction, and microalbuminuria of incipient diabetic nephropathy in patients. Diabetes. 54:2206-2211.
19. Miyazaki, Y., Cersosimo, E., Triplitt, C., and DeFronzo, R.A. 2007. Rosiglitazone decreases albuminuria in type 2 diabetic patients. Kidney Int. 72:1367-1373.
20. Lee, M.J., et al. 2007. A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy. Am. J. Physiol. Renal Physiol. 292:F617-F627.