Structural Insight into Substrate Binding and Catalysis of a Novel 2-Keto-3-deoxy-d-arabinonate Dehydratase Illustrates Common Mechanistic Features of the FAH Superfamily

Journal of Molecular Biology

Volumn 379, Issue 2, 2008, Pages 357-371

  Brouns, Stan J J ^a   Barends, Thomas R M ^b   Worm, Petra ^a   Akerboom, Jasper ^a   Turnbull, Andrew P ^c   Salmon, Laurent ^d   van der Oost, John ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^c HAHN MEITNER INSTITUT   (Germany)

^d UNIVERSITÉ PARIS SUD   (France)

Author keywords

2 keto 3 deoxy d arabinonate dehydratase; Archaea; FAH superfamily

Indexed keywords

2 KETO 3 DEOXY ARABINONATE DEHYDRATASE; 2 OXOBUTYRIC ACID; 2,5 DIOXOPENTANOATE; ALDEHYDE; BASE; CALCIUM ION; CARBONYL DERIVATIVE; CARBOXYLIC ACID; FUMARYLACETOACETASE; GLUTAMIC ACID; HYDROLYASE; MAGNESIUM; METAL ION; PROTON; WATER;

ACIDITY; ALPHA HELIX; ARTICLE; BETA SHEET; COMPARATIVE STUDY; CRYSTAL STRUCTURE; DEHYDRATION; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; ENZYME SUBUNIT; INTROSPECTION; MOLECULAR EVOLUTION; MOLECULE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY;

ARCHAEA; SULFOLOBUS SOLFATARICUS;

EID: 43049084363     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.03.064     Document Type: Article

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