Acute haematogenous osteomyelitis in children: Is there any evidence for how long we should treat?

Current Opinion in Infectious Diseases

Volumn 21, Issue 3, 2008, Pages 258-262

  Weichert, Stefan ^a,d   Sharland, Mike ^a   Clarke, Nicholas M P ^b   Faust, Saul N ^c  

^a ST GEORGE S HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d ST GEORGE'S UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Acute haematogenous osteomyelitis; Antibiotics; Children; Randomized controlled trial

Indexed keywords

AMOXICILLIN; AMPICILLIN; ANTIBIOTIC AGENT; BACAMPICILLIN; BETA LACTAM; CEFACLOR; CEFADROXIL; CEFALEXIN; CEFALOTIN; CEFAZOLIN; CEFEMANDOLE; CEFOTAXIME; CEFRADINE; CEFTRIAXONE; CILASTATIN; CLINDAMYCIN; CLOXACILLIN; DICLOXACILLIN; IMIPENEM; MACROLIDE; METICILLIN; NAFCILLIN; OXACILLIN; PENICILLIN G; PENICILLIN V; SULTAMICILLIN; TECHNETIUM 99M; TIMENTIN;

BACTERIAL INFECTION; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; COMPUTER ASSISTED TOMOGRAPHY; DRUG INHIBITION; GEOGRAPHICAL VARIATION (SPECIES); HEMATOGENOUS OSTEOMYELITIS; HUMAN; LABORATORY TEST; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MORBIDITY; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; REVIEW; TREATMENT DURATION; ULTRASOUND;

ADOLESCENT; ANTI-BACTERIAL AGENTS; CHILD; CHILD, PRESCHOOL; DRUG ADMINISTRATION SCHEDULE; EPIPHYSES; HUMANS; OSTEOMYELITIS; TREATMENT OUTCOME;

EID: 42949167243     PISSN: 09517375     EISSN: None     Source Type: Journal    
DOI: 10.1097/QCO.0b013e3283005441     Document Type: Review

References (54)

1. Gutierrez K. Bone and joint infections in children. Pediatr Clin North Am 2005; 52:779-794; vi. Excellent general review of paediatric osteoarticular infections.
2. Krogstad P. Osteomyelitis and septic arthritis. In: Feigin RD, Cherry JD, Demmler GJ, Kaplan SL, editors. Textbook of pediatric infectious diseases, 5th ed. Philadelphia: Saunders; 2004. pp. 713-736.
3. Dahl LB, Hoyland AL, Dramsdahl H, et al. Acute osteomyelitis in children: a population-based retrospective study 1965 to 1994. Scand J Infect Dis 1998; 30:573-577.
4. Faden H, Grossi M. Acute osteomyelitis in children. Reassessment of etiologic agents and their clinical characteristics. Am J Dis Child 1991; 145:65-69.
5. Scott RJ, Christofersen MR, Robertson WW Jr, et al. Acute osteomyelitis in children: a review of 116 cases. J Pediatr Orthop 1990; 10:649-652.
6. Jaffe HL. Metabolic, degenerative and inflammatory diseases of the bones and joints. Philadelphia: Lea & Feibiger; 1972.
7. Goergens ED, McEvoy A, Watson M, et al. Acute osteomyelitis and septic arthritis in children. J Paediatr Child Health 2005; 41:59-62.
8. Bocchini CE, Hulten KG, Mason EO Jr, et al. Panton-Valentine leukocidin genes are associated with enhanced inflammatory response and local disease in acute hematogenous Staphylococcus aureus osteomyelitis in children. Pediatrics 2006; 117:433-440. Interesting recent epidemiology.
9. Kaplan SL, Hulten KG, Gonzalez BE, et al. Three-year surveillance ofcommunity-acquired Staphylococcus aureus infections in children. Clin Infect Dis 2005; 40:1785-1791.
10. Martinez-Aguilar G, Avalos-Mishaan A, Hulten K, et al. Community-acquired, methicillin-resistant and methicillin-susceptible Staphylococcus aureus musculoskeletal infections in children. Pediatr Infect Dis J 2004; 23:701-706.
11. Arnold SR, Elias D, Buckingham SC, et al. Changing patterns of acute hematogenous osteomyelitis and septic arthritis: emergence of community-associated methicillin-resistant Staphylococcus aureus. J Pediatr Orthop 2006; 26:703-708. Excellent review of the emerging problem of community-associated MRSA in the United States.
12. McCaskill ML, Mason EO Jr, Kaplan SL, et al. Increase of the USA300 clone among community-acquired methicillin-susceptible Staphylococcus aureus causing invasive infections. Pediatr Infect Dis J 2007; 26:1122-1127. Recent description of the changing epidemiology and pathogenicity of invasive S. aureus infections in children.
13. Isaacs D, Moxen ER. Handbook of neonatal infections: a practical guide. London: WB Saunders; 1999.
14. Wong M, Isaacs D, Howman-Giles R, et al. Clinical and diagnostic features of osteomyelitis occurring in the first three months of life. Pediatr Infect Dis J 1995; 14:1047-1053.
15. Howard AW, Viskontas D, Sabbagh C. Reduction in osteomyelitis and septic arthritis related to Haemophilus influenzae type B vaccination. J Pediatr Orthop 1999; 19:705-709.
16. Lauschke FH, Frey CT. Hematogenous osteomyelitis in infants and children in the northwestern region of Namibia. Management and two-year results. J Bone Joint Surg Am 1994; 76:502-510.
17. Unkila-Kallio L, Kallio MJ, Eskola J, et al. Serum C-reactive protein, erythrocyte sedimentation rate, and white blood cell count in acute hematogenous osteomyelitis of children. Pediatrics 1994; 93:59-62.
18. Mazur JM, Ross G, Cummings J, et al. Usefulness of magnetic resonance imaging for the diagnosis of acute musculoskeletal infections in children. J Pediatr Orthop 1995; 15:144-147.
19. Tuson CE, Hoffman EB, Mann MD. Isotope bone scanning for acute osteomyelitis and septic arthritis in children. J Bone Joint Surg Br 1994; 76:306-310.
20. Blickman JG, van Die CE, de Rooy JW. Current imaging concepts in pediatric osteomyelitis. Eur Radiol 2004; 14 (Suppl 4):L55-L64.
21. Capitanio MA, Kirkpatrick JA. Early roentgen observations in acute osteomyelitis. Am J Roentgenol Radium Ther Nucl Med 1970; 108:488-496.
22. Howard CB, Einhorn M, Dagan R, et al. Fine-needle bone biopsy to diagnose osteomyelitis. J Bone Joint Surg Br 1994; 76:311-314.
23. Restrepo S, Vargas D, Riascos R, et al. Musculoskeletal infection imaging: past, present, and future. Curr Infect Dis Rep 2005; 7:365-372.
24. Dich VQ, Nelson JD, Haltalin KC. Osteomyelitis in infants and children. A review of 163 cases. Am J Dis Child 1975; 129:1273-1278.
25. Nelson JD, Bucholz RW, Kusmiesz H, et al. Benefits and risks of sequential parenteral:oral cephalosporin therapy for suppurative bone and joint infections. J Pediatr Orthop 1982; 2:255-262.
26. Stott NS. Review article: paediatric bone and joint infection. J Orthop Surg (Hong Kong) 2001; 9:83-90.
27. Rosey AL, Abachin E, Quesnes G, et al. Development of a broad-range 16S rDNA real-time PCR for the diagnosis of septic arthritis in children. J Microbiol Methods 2007; 68:88-93.
28. Verdier I, Gayet-Ageron A, Ploton C, et al. Contribution of a broad range polymerase chain reaction to the diagnosis of osteoarticular infections caused by Kingella kingae: description of twenty-four recent pediatric diagnoses. Pediatr Infect Dis J 2005; 24:692-696.
29. Lazzarini L, Lipsky BA, Mader JT. Antibiotic treatment of osteomyelitis: what have we learned from 30 years of clinical trials? Int J Infect Dis 2005; 9:127-138.
30. Kaplan SL, Mason EO Jr, Feigin RD. Clindamycin versus nafcillin or methicillin in the treatment of Staphylococcus aureus osteomyelitis in children. South Med J 1982; 75:138-142.
31. Kulhanjian J, Dunphy MG, Hamstra S, et al. Randomized comparative study of ampicillin/sulbactam vs. ceftriaxone for treatment of soft tissue and skeletal infections in children. Pediatr Infect Dis J 1989; 8:605-610.
32. Le Saux N, Howard A, Barrowman NJ, et al. Shorter courses of parenteral antibiotic therapy do not appear to influence response rates for children with acute hematogenous osteomyelitis: a systematic review. BMC Infect Dis 2002; 2:16.
33. Blockey NJ, Watson JT. Acute osteomyelitis in children. J Bone Joint Surg Br 1970; 52:77-87.
34. Feigin RD, Pickering LK, Anderson D, et al. Clindamycin treatment of osteomyelitis and septic arthritis in children. Pediatrics 1975; 55:213-223.
35. Arango JL, Trujillo H, Worren D, et al. Effectiveness of two new cephalosporins, cephazolin and cephapirin, administered intermittently in acute and chronic osteomyelitis in children. J Int Med Res 1976; 4:183-194.
36. Rodriguez W, Ross S, Khan W, et al. Clindamycin in the treatment of osteomyelitis in children: a report of 29 cases. Am J Dis Child 1977; 131:1088-1093.
37. Geddes AM, Dwyer NS, Ball AP, et al. Clindamycin in bone and joint infections. J Antimicrob Chemother 1977; 3:501-507.
38. Tetzlaff TR, McCracken GH Jr, Nelson JD. Oral antibiotic therapy for skeletal infections of children. II. Therapy of osteomyelitis and suppurative arthritis. J Pediatr 1978; 92:485-490.
39. Prober CG, Yeager AS. Use of the serum bactericidal titer to assess the adequacy of oral antibiotic therapy in the treatment of acute hematogenous osteomyelitis. J Pediatr 1979; 95:131-135.
40. Bryson YJ, Connor JD, LeClerc M, et al. High-dose oral dicloxacillin treatment of acute staphylococcal osteomyelitis in children. J Pediatr 1979; 94:673-675.
41. Kolyvas E, Ahronheim G, Marks MI, et al. Oral antibiotic therapy of skeletal infections in children. Pediatrics 1980; 65:867-871.
42. Cole WG, Dalziel RE, Leitl S. Treatment of acute osteomyelitis in childhood. J Bone Joint Surg Br 1982; 64:218-223.
43. Jacobs RF, Augustine RA, Aronson J, et al. Timentin therapy for bone, joint, and deep soft tissue infections in children. Am J Med 1985; 79:188-191.
44. Yogev R, Shulman ST, Chadwick EG, et al. Once daily ceftriaxone for central nervous system infections and other serious pediatric infections. Pediatr Infect Dis 1986; 5:298-303.
45. Freij BJ, Kusmiesz H, Shelton S, et al. Imipenem and cilastatin in acute osteomyelitis and suppurative arthritis. Therapy in infants and children. Am J Dis Child 1987; 141:335-342.
46. Jacobs RF, Darville T, Parks JA, et al. Safety profile and efficacy of cefotaxime for the treatment of hospitalized children. Clin Infect Dis 1992; 14:56-65.
47. Peltola H, Unkila-Kallio L, Kallio MJ. Simplified treatment of acute staphylococcal osteomyelitis of childhood. The Finnish Study Group. Pediatrics 1997; 99:846-850.
48. Moylett EH, Rossmann SN, Epps HR, et al. Importance of Kingella kingae as a pediatric pathogen in the United States. Pediatr Infect Dis J 2000; 19:263-265.
49. Yagupsky P. Kingella kingae: from medical rarity to an emerging paediatric pathogen. Lancet Infect Dis 2004; 4:358-367.
50. Bone and Joint Disorders. In: Behrman RE, Kliegman RM, Jenson HB, editors. Nelson textbook of pediatrics. London: Saunders; 2003. pp. 2297-2302.
51. Ring D, Johnston CE II, Wenger DR. Pyogenic infectious spondylitis in children: the convergence of discitis and vertebral osteomyelitis. J Pediatr Orthop 1995; 15:652-660.
52. Roine I, Faingezicht I, Arguedas A, et al. Serial serum C-reactive protein to monitor recovery from acute hematogenous osteomyelitis in children. Pediatr Infect Dis J 1995; 14:40-44.
53. Leigh DA. Determination of serum and bone concentrations of cephradine and cefuroxime by HPLC in patients undergoing hip and knee joint replacement surgery. J Antimicrob Chemother 1989; 23:877-883.
54. Darley ES, MacGowan AP. Antibiotic treatment of Gram-positive bone and joint infections. J Antimicrob Chemother 2004; 53:928-935.