Novel echinocandin antifungals. Part 2: Optimization of the side chain of the natural product FR901379. Discovery of micafungin

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 9, 2008, Pages 2886-2890

  Tomishima, Masaki ^a   Ohki, Hidenori ^a   Yamada, Akira ^a   Maki, Katsuyuki ^a   Ikeda, Fumiaki ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Antifungal; Aspergillus fumigatus; Candida albicans; Echinocandin; FK463; FR13153; FR901379; Isoxazole; Micafungin; Natural product

Indexed keywords

ECHINOCANDIN; FR 131535; FR 901379; MICAFUNGIN; NATURAL PRODUCT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CANDIDIASIS; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG POTENCY; HEMOLYSIS; IC 50; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; TREATMENT OUTCOME;

ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; BIOLOGICAL PRODUCTS; CANDIDA ALBICANS; ECHINOCANDINS; LIPOPROTEINS; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; PEPTIDES, CYCLIC; STRUCTURE-ACTIVITY RELATIONSHIP;

ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS;

EID: 42949150245     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.093     Document Type: Article

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