Hydroxyurea induced acute elevations in liver function tests

Journal of Oncology Pharmacy Practice

Volumn 14, Issue 1, 2008, Pages 61-63

  Hallam, Mike J ^a   Kolesar, Jill M ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Hydroxyurea; Liver function tests; Polycythemia vera

Indexed keywords

HYDROXYUREA; JANUS KINASE 2; ANTINEOPLASTIC AGENT;

AGED; ANOREXIA; ARTICLE; CASE REPORT; CHILL; CLINICAL FEATURE; DIZZINESS; DRUG EFFICACY; DRUG FEVER; DRUG RESPONSE; DRUG WITHDRAWAL; FATIGUE; HEMATOCRIT; HUMAN; LIVER DYSFUNCTION; LIVER FUNCTION TEST; MALE; NAUSEA; PHLEBOTOMY; POLYCYTHEMIA VERA; PRIORITY JOURNAL; SIDE EFFECT; THROMBOCYTE COUNT; VOMITING; CHEMICALLY INDUCED DISORDER; LIVER DISEASE;

AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; HUMANS; HYDROXYUREA; LIVER DISEASES; LIVER FUNCTION TESTS; MALE; POLYCYTHEMIA VERA;

EID: 42949128749     PISSN: 10781552     EISSN: None     Source Type: Journal    
DOI: 10.1177/1078155207086814     Document Type: Article

References (10)

1. Barbui T., Finazzi G. Evidence-based management of polycythemia vera. Best Pract Res Clin Haematol 2006; 19: 483-9.
2. Gwilt PR, Tracewell WG Pharmacokinetics and pharacodynamics of hydroxyurea. Clin Pharmacokinet 1998; 34: 347-58.
3. Prchal JT Classification and molecular biology of polycythemias (erythrocytoses) and thrombocytosis. Hematol Oncol Clin North Am 2003; 17: 1151-8.
4. Lori F., Pollard RB, Whitman L. et al. Lowering the dose of hydroxyurea minimizes toxicity and maximizes anti-HIV potency. AIDS Res Hum Retroviruses 2005; 21: 263-72.
5. Havlir DV, Gilbert PB, Bennett K., Collier AC, Hirsch MS, Tebas P., Adams EM, Wheat LJ, Goodwin D., Schnittman S., Holohan MK, Richman DD; ACTG 5025 Study Group. Effects of treatment intensification with hydroxyurea in HIV-infected patients with virologic suppression. AIDS 2001; 27: 1379-8.
6. Sulkowski MS, Thomas DL, Chaisson RE, Moore RD Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection. JAMA 2000; 283: 74-80.
7. Westerman DA, Schwarer A., Grigg AP Hydroxyurea-induced fever and hepatitis. Aust N Z J Med 1998; 28: 657-9.
8. Heddle R., Calvert AF Hydroxyurea induced hepatitis. Med J Aust 1980; 1: 121.
9. Sharon R., Tatarsky I., Ben-Arieh Y. Treatment of Polycythemia Vera with Hydroxyurea. Cancer 1986; 57: 718-20.
10. Malec J., Szczepanska I., Grabarczyk M., Przybyszewski WM, Kopec-Szlezak J., Sitarska E. Hydroxyurea-induced toxic side-effects in animals and an attempt at reducing them with vitamins E and C. Neoplasma 1989; 36: 427-35.