Correlates of ACE activity in macroalbuminuric type 2 diabetic patients treated with chronic ACE inhibition

Nephrology Dialysis Transplantation

Volumn 23, Issue 4, 2008, Pages 1274-1277

  Nikzamir, Abdolrahim ^a   Nakhjavani, Manouchehr ^a   Esteghamati, Alireza ^a   Rashidi, Armin ^a,b  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Mellat Park   (Iran)

Author keywords

ACE activity; Diabetic nephropathy; Macroalbuminuria; Polymorphism; Type 2 diabetes

Indexed keywords

ACETYLCHOLINESTERASE; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; INSULIN; DIPEPTIDYL CARBOXYPEPTIDASE; DNA;

ADULT; AGED; ALBUMINURIA; ALLELE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; MACROALBUMINURIA; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; BLOOD; BODY MASS; COMPARATIVE STUDY; DIABETIC NEPHROPATHY; DRUG EFFECT; ENZYMOLOGY; FOLLOW UP; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HOSPITALIZATION; IRAN; MIDDLE AGED; POLYMERASE CHAIN REACTION; PREVALENCE; PROGNOSIS; RETROSPECTIVE STUDY; TIME;

AGED; AGED, 80 AND OVER; ALBUMINURIA; ALLELES; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DNA; FEMALE; FOLLOW-UP STUDIES; GENOTYPE; HUMANS; IRAN; MALE; MIDDLE AGED; PEPTIDYL-DIPEPTIDASE A; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PREVALENCE; PROGNOSIS; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 42949099993     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfm745     Document Type: Article

References (24)

1. Rigat B, Hubert C, Alhenc-Gelas F et al. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86: 1343-1346
2. Scharplatz M, Puhan MA, Steurer J et al. Does the Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism modify the response to ACE inhibitor therapy? - a systematic review. Curr Control Trials Cardiovasc Med 2005; 6: 16
3. Jacobsen PK. Preventing end stage renal disease in diabetic patients - genetic aspect (part I). J Renin Angiotensin Aldosterone Syst 2005; 6: 1-14
4. Investigators for HOPE study. Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators. Lancet 2000; 355: 253-259
5. Brenner BM, Cooper ME, de Zeeuw D et al. (RENAAL Study Investigators) Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001; 345: 861-869
6. Colhoun HM, Lee ET, Bennett PH et al. Risk factors for renal failure: the WHO multinational study of vascular disease in diabetes. Diabetologia 2001; 44: S46-S53
7. de Zeeuw D, Remuzzi G, Parving HH et al. Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL. Kidney Int 2004; 65: 2309-2320
8. de Zeeuw D, Remuzzi G, Parving HH et al. Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy. Circulation 2004; 110: 921-927
9. World Health Organisation Study Group. Diabetes mellitus. WHO Tech Rep Ser 1985; 727: 1-104
10. Nakhjavani M, Esfahanian F, Jahanshahi A et al. The relationship between the insertion/deletion polymorphism of the ACE gene and hypertension in Iranian patients with type 2 diabetes. Nephrol Dial Transplant 2007 (In press)
11. Lieberman J. Elevation of serum angiotensin-converting-enzyme (ACE) level in sarcoidosis. Am J Med 1975; 59: 365-372
12. Lieberman J. The specificity and nature of serum-angiotensin converting enzyme (serum ACE) elevations in sarcoidosis. Ann N Y Acad Sci 1976; 278: 488-497
13. Ha SK, Park HC, Park HS et al. ACE gene polymorphism and progression of diabetic nephropathy in Korean type 2 diabetic patients: effect of ACE gene DD on the progression of diabetic nephropathy. Am J Kidney Dis 2003; 41: 943-949
14. So WY, Ma RC, Ozaki R et al. Angiotensin-converting enzyme (ACE) inhibition in type 2, diabetic patients - interaction with ACE insertion/deletion polymorphism. Kidney Int 2006; 69: 1438-1443
15. Moriyama T, Kitamura H, Ochi S et al. Association of angiotensin I-converting enzyme gene polymorphism with susceptibility to antiproteinuric effect of angiotensin I-converting enzyme inhibitors in patients with proteinuria. J Am Soc Nephrol 1995; 6: 1676-1678
16. Ha SK, Yong Lee S, Su Park H et al. ACE DD genotype is more susceptible than ACE II and ID genotypes to the antiproteinuric effect of ACE inhibitors in patients with proteinuric non-insulin-dependent diabetes mellitus. Nephrol Dial Transplant 2000; 15: 1617-1623
17. Jacobsen PK, Tarnow L, Parving HH. Time to consider ACE insertion/ deletion genotypes and individual renoprotective treatment in diabetic nephropathy? Kidney Int 2006; 69: 1293-1295
18. Jacobsen PK, Rossing K, Rossing P et al. Angiotensin-converting enzyme (ACE) gene polymorphism and ACE-inhibition in diabetic nephropathy. Kidney Int 1998; 53: 1002-1006
19. Jacobsen PK. Preventing end-stage renal disease in diabetic patients - dual blockade of the renin-angiotensin system (Part II). J Renin Angiotensin Aldosterone Syst 2005; 6: 55-68
20. Larochelle P, Genest J, Kuchel O et al. Effect of captopril on blood pressure, plasma renin activity and angiotensin I converting enzyme activity. Can Med Assoc J 1979; 121: 309-313
21. Fyhrquist F, Forslund T, Tikkanen I et al. Induction of angiotensin converting enzyme in rat lung with captopril (SQ14225). Eur J Pharmacol 1980; 67: 473-475
22. Boomsma F, DeBruyn JHB, Derkx FHM et al. Opposite effects of captopril on angiotensin I-converting enzyme activity and concentration, relation between enzyme inhibition and long-termblood pressure response. Clin Sci 1981; 60: 491-498
23. Sassano P, Chatellier G, Billaud E et al. Treatment of mild to moderate hypertension with or without the converting enzyme inhibitor enalapril. Am J Med 1987; 83: 227-235
24. Costerousse O, Allegrini J, Clozel JP et al. Angiotensin I-converting enzyme inhibition but not angiotensin II suppression alters angiotensin I-converting enzyme gene expression in vessels and epithelia. J Pharmacol Exp Ther 1998; 284: 1180-1187