Strychnine - A killer from the past

Israel Medical Association Journal

Volumn 10, Issue 2, 2008, Pages 142-145

  Makarovsky, Igor ^a   Markel, Gal ^a,b   Hoffman, Azik ^a   Schein, Ophir ^a   Brosh Nissimov, Tal ^a   Tashma, Zeev ^a,c   Dushnitsky, Tsvika ^a   Eisenkraft, Arik ^a,d  

^a MEDICAL CORPS   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^d NONE   (Israel)

Author keywords

Convulsions; Glycine antagonist; Health effects; Medical care; Strychnine; Terror

Indexed keywords

ACTIVATED CARBON; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; BICARBONATE; DIAZEPAM; MIDAZOLAM; NEUROMUSCULAR BLOCKING AGENT; PANCURONIUM; STRYCHNINE; VECURONIUM; CONVULSANT AGENT;

ANOXIA; ARTICLE; ARTIFICIAL VENTILATION; CAUSE OF DEATH; CHEMICAL STRUCTURE; CONVULSION; DIFFERENTIAL DIAGNOSIS; EPILEPSY; FATALITY; FLUID RESUSCITATION; HUMAN; HYPERTHERMIA; INTOXICATION; KIDNEY FAILURE; LETHAL DOSE; MENINGITIS; METABOLIC ACIDOSIS; MULTIPLE ORGAN FAILURE; MYOGLOBINURIA; NONHUMAN; PALLIATIVE THERAPY; PATIENT MONITORING; RABIES; REHYDRATION; REPEATED DRUG DOSE; RESPIRATORY ACIDOSIS; RESPIRATORY FAILURE; RESUSCITATION; RHABDOMYOLYSIS; STRUCTURE ANALYSIS; STRYCHNINE INTOXICATION; TERRORISM; TETANUS; CHEMICALLY INDUCED DISORDER; GRAND MAL EPILEPSY; MUSCLE HYPERTONIA; REVIEW; RISK FACTOR;

CONVULSANTS; DIAGNOSIS, DIFFERENTIAL; EPILEPSY, TONIC-CLONIC; HUMANS; MUSCLE HYPERTONIA; OVERDOSE; RISK FACTORS; STRYCHNINE;

EID: 42949096900     PISSN: 15651088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Philippe G, Angenot L, Tits M, Frederich M. About the toxicity of some Strychnos species and their alkaloids. Toxicon 2004;44:405-16.
2. Gosselin RE, Smith RP, Hodge HC. Clinical Toxicology of Commercial Products. 5th edn. Baltimore/London: Williams & Wilkins, 1984:375-9.
3. Radosavljevic J, Jeffries WS, Peter JV. Intentional strychnine use and overdose - an entity of the past? Crit Care Resusc 2006;8:260-1.
4. The Committee for Veterinary Medicinal Products. Strychni Semen. Summary Report. www emea eu int/pdfs/vet/mrls/050498enpdf 1999 March.
5. Borges A, Abrantes J, Teixeira MT, Parada P. Strychnine. wwwinchemorg/ documents/pims/chemical/pim507htm 2006.
6. Burn DJ, Tomson CR, Seviour J, Dale G. Strychnine poisoning as an unusual cause of convulsions. Postgrad Med J 1989;65:563-4.
7. Strychnine. In: Budavari S, ed. The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals. 12th edn. Rahway, NJ: Merck and Co. Inc., 1996:1512.
8. Strychnine Material Safety Data Sheet. wwwjtbakercom/msds/englishhtml/ s6976htm 2006.
9. Aprison MH, Lipkowitz KB, Simon JR. Identification of a glycine-like fragment on the strychnine molecule. J Neurosci Res 1987; 17:209-13.
10. Aprison MH, Galvez-Ruano E, Lipkowitz KB. Identification of a second glycine-like fragment on the strychnine molecule. J Neurosci Res 1995;40:396-400.
11. Klaassen CD. Nonmetallic environmental toxicants: air pollutants, solvents and vapors, and pesticides. In: Hardman JG, Limbird LE, eds. Goodman & Gilman's Pharmacological Basis of Therapeutics. 10th edn. New York: McGraw-Hill, 2001:1894-5.
12. Chan Y-C. Strychnine. In: Goldfrank LR, Flomenbaum M, Hoffman RJ, Howland M-A, Lewin NA, Nelson LS, eds. Goldfrank's Toxocologic Emergencies. 8th edn. New York: McGraw-Hill, 2002: 1492-6.
13. Cotten MS, Lane DH. Massive strychnine poisoning: a successful treatment. J Miss State Med Assoc 1966;7:466-8.
14. Greene R, Meatherall R. Dermal exposure to strychnine. J Anal Toxicol 2001;25:344-7.
15. Lambert JR, Byrick RJ, Hammeke MD. Management of acute strychnine poisoning. Can Med Assoc J 1981;124:1268-70.
16. Mishima M, Tanimoto Y, Oguri Z, Yoshimura H. Metabolism of strychnine in vitro. Drug Metab Dispos 1985;13:716-21.
17. Boyd RE, Brennan PT, Deng JF, Rochester DF, Spyker DA. Strychnine poisoning. Recovery from profound lactic acidosis, hyperthermia, and rhabdomyolysis. Am J Med 1983;74:507-12.
18. Worthley LI. Clinical Toxicology. Part II: Diagnosis and management of uncommon poisonings. Crit Care Resusc 2002;4:216-30.
19. Billimoria RB, Naik PR, Satoskar RS. Effect ot diazepam alone and in combination with chlorpromazine or propranolol in experimentally induced convulsions in mice. J Postgrad Med 1981; 27:73-9.
20. O'Callaghan WG, Joyce N, Counihan HE, Ward M, Lavelle P, O'Brien E. Unusual strychnine poisoning and its treatment: report of eight cases. Br Med J (Clin Res Ed) 1982;285:478.
21. Starretz-Hacham O, Sofer S, Lifshitz M. Strychnine intoxication in a child. IMAJ 2003;5:531-2.
22. HSDB - Hazardous Substances Data Bank. Strychnine. http://toxnetnlmnihgov/cgi-bin/sis/search/f?/temp/-D9QRS8:1 2007.
23. Perper JA. Fatal strychnine poisoning - a case report and review of the literature. J Forens Sci 1985;30:1248-55.
24. Nishiyama T, Nagase M. Strychnine poisoning: natural course of a nonfatal case. Am J Emerg. Med 1995;13:172-3.
25. Giese P. Norma Jean Croy - California History: The Hidden Genocide. http://wwwkstromnet/isk/stories/normtreahtml 1995.
26. Sax NI. Strychnine. Dangerous Properties of Industrial Material. New York: Van Nostrand Reinhold, 1988:78-83.
27. Gossel TA, Bricker JD. Principles of Clinical Toxicology. New York: Raven Press, 1994:350-5.
28. Conn HJ. Rakel: Conn's Current Therapy. wwwmdconsultcom 2007(59).
29. Blain PG, Nightingale S, Stoddart JC. Strychnine poisoning: abnormal eye movements. J Toxicol Clin Toxicol 1982;19:215-17.
30. Hayes WJ. Pesticides Studied in Man. Baltimore/London: Williams & Wilkins, 1982:96-101.
31. Yamarick W, Walson P, DiTraglia J. Strychnine poisoning in an adolescent. J Toxicol Clin Toxicol 1992;30:141-8.