Effect of pulsatile flow on the osteogenic differentiation of bone marrow stromal cells in porous scaffolds

Biomedical Sciences Instrumentation

Volumn 44, Issue , 2008, Pages 471-476

  Kavlock, Katherine D ^a   Goldstein, Aaron S ^a  

^a Medical Center Boulevard   (United States)

Author keywords

Bone graft substitute; Fluid flow; Frequency; Osteogenic; PLGA; Pulsatile; Scaffold; Tissue engineering

Indexed keywords

BIOREACTORS; BONE; GRAFTS; NUTRIENTS;

POROUS SCAFFOLDS; STROMAL CELLS;

TISSUE ENGINEERING;

ALKALINE PHOSPHATASE; OSTEOPONTIN; POLYGLACTIN;

ANIMAL CELL; BIOREACTOR; BONE PROSTHESIS; CELL COUNT; CELL DIFFERENTIATION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; IMPLANT; NONHUMAN; OSTEOBLAST; POROSITY; PROTEIN EXPRESSION; PULSATILE FLOW; RAT; SCANNING ELECTROCHEMICAL MICROSCOPY; STATISTICAL ANALYSIS; TISSUE ENGINEERING;

EID: 42949095855     PISSN: 00678856     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (17)

1. A. S. Goldstein, T. M. Juarez, C. D. Helmke, M. C. Gustin, and A. G. Mikos, "Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds," Biomaterials, vol. 22, pp. 1279-88, Jun 2001.
2. J. F. Alvarez-Barreto, S. M. Linehan, R. L. Shambaugh, and V. I. Sikavitsas, "Flow perfusion improves seeding of tissue engineering scaffolds with different architectures," Ann Biomed Eng, vol. 35, pp. 429-42, Mar 2007.
3. L. Meinel, V. Karageorgiou, R. Fajardo, B. Snyder, V. Shinde-Patil, L. Zichner, D. Kaplan, R. Langer, and G. Vunjak-Novakovic, "Bone tissue engineering using human mesenchymal stem cells: effects of scaffold material and medium flow," Ann Biomed Eng, vol. 32, pp. 112-22, Jan 2004.
4. G. N. Bancroft, V. I. Sikavitsas, J. van den Dolder, T. L. Sheffield, C. G. Ambrose, J. A. Jansen, and A. G. Mikos, "Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner," Proc Natl Acad Sci U S A, vol. 99, pp. 12600-5, Oct 1 2002.
5. J. van den Dolder, G. N. Bancroft, V. I. Sikavitsas, P. H. Spauwen, J. A. Jansen, and A. G. Mikos, "Flow perfusion culture of marrow stromal osteoblasts in titanium fiber mesh," J Biomed Mater Res A, vol. 64, pp. 235-41, Feb 1 2003.
6. C. R. Jacobs, C. E. Yellowley, B. R. Davis, Z. Zhou, J. M. Cimbala, and H. J. Donahue, "Differential effect of steady versus oscillating flow on bone cells," J Biomech, vol. 31, pp. 969-76, Nov 1998.
7. M. M. Thi, D. A. Iacobas, S. Iacobas, and D. C. Spray, "Fluid Shear Stress Up-regulates Vascular Endothelial Growth Factor Gene Expression in Osteoblasts," Ann N Y Acad Sci, Jul 23 2007.
8. J. Vance, S. Galley, D. F. Liu, and S. W. Donahue, "Mechanical stimulation of MC3T3 osteoblastic cells in a bone tissue-engineering bioreactor enhances prostaglandin E2 release," Tissue Eng, vol. 11, pp. 1832-9, Nov-Dec 2005.
9. J. You, G. C. Reilly, X. Zhen, C. E. Yellowley, Q. Chen, H. J. Donahue, and C. R. Jacobs, "Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts," J Biol Chem, vol. 276, pp. 13365-71, Apr 20 2001.
10. M. G. Mullender, S. J. Dijcks, R. G. Bacabac, C. M. Semeins, J. J. Van Loon, and J. Klein-Nulend, "Release of nitric oxide, but not prostaglandin E2, by bone cells depends on fluid flow frequency," J Orthop Res, vol. 24, pp. 1170-7, Jun 2006.
11. E. A. Nauman, R. L. Satcher, T. M. Keaveny, B. P. Halloran, and D. D. Bikle, "Osteoblasts respond to pulsatile fluid flow with short-term increases in PGE(2) but no change in mineralization," J Appl Physiol, vol. 90, pp. 1849-54, May 2001.
12. K. D. Kavlock, T. W. Pechar, J. O. Hollinger, S. A. Guelcher, and A. S. Goldstein, "Synthesis and characterization of segmented poly(esterurethane urea) elastomers for bone tissue engineering," Acta Biomater, vol. 3, pp. 475-84, Jul 2007.
13. A. S. Goldstein, "Effect of seeding osteoprogenitor cells as dense clusters on cell growth and differentiation," Tissue Engineering, vol. 7, pp. 817-827, Dec 2001.
14. H. Hosseinkhani, Y. Inatsugu, Y. Hiraoka, S. Inoue, and Y. Tabata, "Perfusion culture enhances osteogenic differentiation of rat mesenchymal stem cells in collagen sponge reinforced with poly(glycolic Acid) fiber," Tissue Eng, vol. 11, pp. 1476-88, Sep-Oct 2005.
15. H. L. Holtorf, J. A. Jansen, and A. G. Mikos, "Flow perfusion culture induces the osteoblastic differentiation of marrow stroma cell-scaffold constructs in the absence of dexamethasone," J Biomed Mater Res A, vol. 72, pp. 326-34, Mar 1 2005.
16. H. L. Holtorf, T. L. Sheffield, C. G. Ambrose, J. A. Jansen, and A. G. Mikos, "Flow perfusion culture of marrow stromal cells seeded on porous biphasic calcium phosphate ceramics," Ann Biomed Eng, vol. 33, pp. 1238-48, Sep 2005.
17. M. E. Gomes, C. M. Bossano, C. M. Johnston, R. L. Reis, and A. G. Mikos, "In vitro localization of bone growth factors in constructs of biodegradable scaffolds seeded with marrow stromal cells and cultured in a flow perfusion bioreactor," Tissue Eng, vol. 12, pp. 177-88, Jan 2006.