Reactivation of inactive X chromosome: A potential culprit and therapeutic target for Systemic lupus erythematosus

Medical Hypotheses

Volumn 70, Issue 6, 2008, Pages 1231-1232

  Pan, Hai Feng ^a   Ye, Dong Qing ^a   Li, Xiang Pei ^b  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b ANHUI PROVINCIAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; ESTROGEN; PROLACTIN; STEROID HORMONE;

DISEASE PREDISPOSITION; DNA METHYLATION; DRUG MECHANISM; DRUG TARGETING; GENE ACTIVATION; HORMONE BLOOD LEVEL; HUMAN; KLINEFELTER SYNDROME; LETTER; PRIORITY JOURNAL; SEX DIFFERENCE; SYSTEMIC LUPUS ERYTHEMATOSUS; TURNER SYNDROME; X CHROMOSOME;

AZACITIDINE; CD40 LIGAND; DNA METHYLATION; ENZYME INHIBITORS; FEMALE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MODELS, BIOLOGICAL; SEX FACTORS; T-LYMPHOCYTES; X CHROMOSOME INACTIVATION;

EID: 42749096496     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2007.12.012     Document Type: Letter

References (11)

1. Whitacre C.C. Sex differences in autoimmune disease. Nat Immunol 2 (2001) 777-780
2. Yang M., Huang L., Liu W., et al. Prolactin may be a promising therapeutic target for myasthenia gravis: hypothesis and importance. Med Hypotheses (2007) 10.1016/j.mehy.2007.06.044
3. Vidaver R. Molecular and clinical evidence of the role of estrogen in lupus. Trends Immunol 23 (2002) 229-230
4. Dugernier T., Huaux J.P., Coche E., et al. Klinefelter's syndrome and lupus erythematosus: report of a case. Clin Rheumatol 6 (1987) 84-87
5. Sasaki N., Yamauchi K., Sato R., et al. Klinefelter's syndrome associated with systemic lupus erythematosus and autoimmune hepatitis. Mod Rheumatol 16 (2006) 305-308
6. Gilliland W.R., and Stashower M.E. Klinefelter's syndrome and systemic lupus erythematosus. Clin Exp Rheumatol 18 (2000) 107-109
7. Holland C. 47, Xxx in an adolescent with premature ovarian failure and autoimmune disease. J Pediatr Adolesc Gynecol 13 (2000) 93
8. Balestrazzi P., Ferraccioli G.F., Ambanelli U., et al. Juvenile rheumatoid arthritis in Turner's syndrome. Clin Exp Rheumatol 4 (1986) 61-62
9. Singer-Sam J., and Riggs A.D. X chromosome inactivation and DNA methylation. EXS 64 (1993) 358-384
10. Mohandas T., Sparkes R.S., Bishop D.F., et al. Frequency of reactivation and variability in expression of X-linked enzyme loci. Am J Hum Genet 36 (1984) 916-925
11. Lu Q., Wu A., Tesmer L., et al. Demethylation of CD40LG on the inactive X in T cells from women with lupus. J Immunol 179 (2007) 6352-6358