Transforming growth factor β suppresses β-catenin/Wnt signaling and stimulates an adhesion response in human colon carcinoma cells in a Smad4/DPC4 independent manner

Cancer Letters

Volumn 264, Issue 2, 2008, Pages 281-287

  Wang, Huijun ^a   Rajan, Shanthi ^b   Liu, Guangming ^c   Chakrabarty, Subhas ^c  

^a FUDAN UNIVERSITY   (China)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Catenin; Colon cancer; Smads; TCF4; TGF

Indexed keywords

BETA CATENIN; SMAD PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

ARTICLE; CELL ADHESION; COLON CARCINOMA; CONTROLLED STUDY; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

BETA CATENIN; CELL ADHESION; CELL LINE, TUMOR; COLONIC NEOPLASMS; HUMANS; MICROSCOPY, CONFOCAL; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEINS;

EID: 42749093134     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.01.039     Document Type: Article

References (26)

1. Markowitz S., Wang J., Myeroff L., Parsons R., Sun L.-Z., Lutterbaugh J., Fan R.S., Zborowska E., Kinzler K.W., Vogelstein B., Brattain M.G.B., and Willson J.K.V. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 268 (1995) 1336-1338
2. Brattain M.G., Markowitz S.D., and Willson J.K. The type II transforming growth factor-beta receptor as a tumor-suppressor gene. Curr. Opin. Oncol. 8 (1996) 49-53
3. Brunschwig E.B., Wilson K., Mack D., Dawson D., Lawrence E., Willson J.K.V., lu S., Nosrati A., Rerko M., Swinler S., Beard L., Lutterbaugh J.D., Willis J., Platzer P., and Markowitz S. PMEPA1, a transforming growth factor-beta-induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer. Cancer Res. 63 (2003) 1568-1575
4. Chakrabarty S., and Wang H. Cellular adhesion and control of colon epithelial cell growth and differentiation: role of transforming growth factor β and the calcium sensing receptor. J. Clin. Ligand Assay 27 (2004) 104-111
5. Brattain M.G., Levine A.E., Chakrabarty S., Yeoman L.C., Willson J.K.V., and Long B.H. Heterogeneity of human colon carcinoma. Cancer Met. Rev. 3 (1984) 177-191
6. Chakrabarty S. Regulation of human colon carcinoma cell adhesion to extracellular matrix by transforming growth factor-β. Int. J. Cancer 50 (1992) 968-973
7. Gong J.G., Ammanamanchi S., Ko T.C., and Brattain M.G. Transforming growth factor-β1 increases the stability of p21/WAF1/CIP1 protein and inhibits CDK2 kinase activity in human colon carcinoma FET cells. Cancer Res. 63 (2003) 3340-3346
8. Wang H., Radjendirane V., Wary K.K., and Chakrabarty S. Transforming growth factor β regulates cell-cell adhesion through extracellular matrix remodeling and activation of focal adhesion kinase in human colon carcinoma Moser cells. Oncogene 23 (2004) 5558-5561
9. Chakrabarty S., Rajagopal S., and Moskal T.L. Protein kinase Cα controls the adhesion but not the antiproliferative response of human colon carcinoma cells to transforming growth factor β1: identification of two distinct branches of post-protein kinase Cα adhesion signal pathway. Lab. Invest. 78 (1998) 413-421
10. Huang S., and Chakrabarty S. Regulation of fibronectin and laminin receptor expression, fibronectin and laminin secretion in human colon cancer cells by transforming growth factor β1. Int. J. Cancer 57 (1994) 742-746
11. Wang H., and Chakrabarty S. Requirement of protein kinase Cα, extracellular matrix remodeling and cell-matrix interaction for transforming growth factor β-regulated expression of E-cadherin and catenins. J. Cell. Physiol. 187 (2001) 188-195
12. Chakrabarty S., Jan Y., Brattain M.G., Tobon A., and Varani J. Diverse cellular responses elicited from human colon carcinoma cells by transforming growth factor-β. Cancer Res. 49 (1989) 2112-2117
13. Chakrabarty S., Fan D., and Varani J. Regulation of differentiation and cellular proliferation in human colon carcinoma cells by transforming growth factor beta 1 and beta 2. Int. J. Cancer 46 (1990) 493-499
14. Massague J. Receptors of the TGFβ family. Cell 69 (1992) 1067-1070
15. Lagna G., Hata A., Hemmati-Brivanlou A., and Massague J. Partnership between DPC4 and SMAD proteins in TGF-beta signaling pathways. Nature 383 (1996) 832-836
16. Zhang Y., Musci T., and Derynck R. The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function. Curr. Biol. 7 (1997) 270-276
17. Zawei L., Dai J.L., Buckhaults P., Zhou S., Kinzler K.W., Vogelstein B., and Kern S.E. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol. Cell 1 (1998) 611-617
18. Zhang L., Graziano K., Pham T., Logsdon C.D., and Simeone D.M. Adenovirus-mediated gene transfer of dominant-negative Smad4 blocks TGF-beta signaling in pancreatic acinar cells. Am. J. Physiol. Gastrointest. Liver Physiol. 280 (2001) G1247-G1253
19. Yingling J.M., Datto M.B., Wong C., Frederic J.P., Liberati N.T., and Wang X.F. Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein. Mol. Cell. Biol. 17 (1997) 7019-7028
20. Liu F., Pouponnot C., and Massague J. Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes. Genes Dev. 11 (1997) 3157-3167
21. Fink S.P., Swinler S.E., Lutterbaugh J.D., Massague J., Thiagalingam S., Kinzler K.W., Vogelstein B., Willson J.K.V., and Markowitz S. Transforming growth factor-β-induced growth inhibition in a Smad4 mutant colon adenoma cell line. Cancer Res. 61 (2001) 256-260
22. Yu L., Hebert M.C., and Zhang Y.E. TGF-β receptor-activated p38 MAP kinase mediates Smad-independent TGF-β responses. EMBO J. 21 (2002) 3749-3759
23. Chakrabarty S., Radjendirane V., Appelman H., and Varani J. Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of β-catenin/TCF activation. Cancer Res. 63 (2003) 67-71
24. 3. Cancer Res. 65 (2005) 493-498
25. waf1 expression and growth inhibition by transforming growth factor β involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells. Cancer Res. 57 (1997) 3929-3934
26. Tang Y., Katuri V., Srinivasan R., Fogt F., Redman R., Anand G., Said A., Fishbein T., Zasloff M., Reddy E.P., Mishra B., and Mishra L. Transforming growth factor-β suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis. Cancer Res. 65 (2005) 4228-4237