Progesterone enhances performance of aged mice in cortical or hippocampal tasks

Neuroscience Letters

Volumn 437, Issue 2, 2008, Pages 116-120

  Frye, Cheryl A ^a   Walf, Alicia A ^a  

^a Departments of Psychology   (United States)

Author keywords

Cognition; Estrogen; Learning; Memory

Indexed keywords

PROGESTERONE;

AGED; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; HIPPOCAMPUS; LEARNING; MALE; MAZE TEST; MEMORY; MOUSE; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RECOGNITION; ROTAROD TEST; TASK PERFORMANCE;

AGING; ANIMALS; AVOIDANCE LEARNING; CEREBRAL CORTEX; COGNITION; FEMALE; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; PATTERN RECOGNITION, VISUAL; PROGESTERONE; PROGESTINS;

EID: 42749089910     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.04.004     Document Type: Article

References (42)

1. K.K. Aenlle, A. Kumar, L. Cui, T.C. Jackson, T.C. Foster, Estrogen effects on cognition and hippocampal transcription in middle-aged mice, Neurobiol. Aging, in press.
2. Björn I., and Bäckström T. Drug related negative side-effects is a common reason for poor compliance in hormone replacement therapy. Maturitas 32 (1999) 77-86
3. Ciriza I., Carrero P., Frye C.A., and Garcia-Segura L.M. Reduced metabolites mediate neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin medroxyprogesterone acetate is not neuroprotective. J. Neurobiol. 66 (2006) 916-928
4. Daniel J.M. Effects of oestrogen on cognition: what have we learned from basic research?. J. Neuroendocrinol. 18 (2006) 787-795
5. Dumas J., Hancur-Bucci C., Naylor M., Sites C., and Newhouse P. Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: evidence for the critical period hypothesis. Horm. Behav. 53 (2008) 159-169
6. Farr S.A., Flood J.F., Scherrer J.F., Kaiser F.E., Taylor G.T., and Morley J.E. Effect of ovarian steroids on footshock avoidance learning and retention in female mice. Physiol. Behav. 58 (1995) 715-723
7. Foster T.C. Interaction of rapid signal transduction cascades and gene expression in mediating estrogen effects on memory over the life span. Front. Neuroendocrinol. 26 (2005) 51-64
8. Frye C.A. Estrus-associated decrements in a water maze task are limited to acquisition. Physiol. Behav. 57 (1995) 5-14
9. Frye C.A., Duffy C.K., and Walf A.A. Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task. Neurobiol. Learn. Mem. 88 (2007) 208-216
10. Frye C.A., and Lacey E.H. Progestins influence performance on cognitive tasks independent of changes in affective behavior. Psychobiology 28 (2000) 550-563
11. Frye C.A., Rhodes M.E., and Dudek B.C. Estradiol to aged male mice improves learning in inhibitory avoidance and water maze tasks. Brain Res. 1036 (2005) 101-108
12. Frye C.A., and Sturgis J.D. Neurosteroids affect spatial/reference, working, and long-term memory of female rats. Neurobiol. Learn. Mem. 64 (1995) 83-96
13. Frye C.A., Sumida K., Dudek B.C., Harney J.P., Lydon J.P., O'Malley B.W., Pfaff D.W., and Rhodes M.E. Progesterone's effects to reduce anxiety behavior of aged mice do not require actions via intracellular progestin receptors. Psychopharmacology 186 (2006) 312-322
14. Frye C.A., Sumida K., Lydon J.P., O'Malley B.W., and Pfaff D.W. Mid-aged and aged wild-type and progestin receptor knockout (PRKO) mice demonstrate rapid progesterone and 3α,5α-THP-facilitated lordosis. Psychopharmacology 185 (2006) 423-432
15. Frye C.A., Edinger K., and Sumida K. Androgen administration to aged male mice increases anti-anxiety behavior and enhances cognitive performance. Neuropsychopharmacology 33 (2008) 1049-1061
16. Frye C.A., and Walf A.A. Effects of progesterone administration and APPswe+PSEN1Deltae9 mutation for cognitive performance of mid-aged mice. Neurobiol. Learn. Mem. 89 (2008) 17-26
17. Galea L.A. Gonadal hormone modulation of neurogenesis in the dentate gyrus of adult male and female rodents. Brain Res. Rev. 57 (2008) 332-341
18. Galea L.A., Ormerod B.K., Sampath S., Kostaras X., Wilkie D.M., and Phelps M.T. Spatial working memory and hippocampal size across pregnancy in rats. Horm. Behav. 37 (2000) 86-95
19. Gibbs R.B. Effects of ageing and long-term hormone replacement on cholinergic neurones in the medial septum and nucleus basalis magnocellularis of ovariectomized rats. J. Neuroendocrinol. 15 (2003) 477-485
20. Gibbs R.B. Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats. Neurobiol. Aging 21 (2000) 107-116
21. Gresack J.E., Kerr K.M., and Frick K.M. Life-long environmental enrichment differentially affects the mnemonic response to estrogen in young, middle-aged, and aged female mice. Neurobiol. Learn. Mem. 88 (2007) 393-408
22. Harburger L.L., Bennett J.C., and Frick K.M. Effects of estrogen and progesterone on spatial memory consolidation in aged females. Neurobiol. Aging 28 (2007) 602-610
23. Hausmann M., Slabbekoorn D., Van Goozen S.H., Cohen-Kettenis P.T., and Gunturkun O. Sex hormones affect spatial abilities during the menstrual cycle. Behav. Neurosci. 114 (2000) 1245-1250
24. Morrison J.H., Brinton R.D., Schmidt P.J., and Gore A.C. Estrogen, menopause, and the aging brain: how basic neuroscience can inform hormone therapy in women. J. Neurosci. 26 (2006) 10332-10348
25. Newhouse P.A., Dumas J.A., Edgren C., Naylor M., Coderre E., and Johnson J. Estradiol with or without progesterone effects on cholinergic-related cognitive performance in older women. Soc. Neurosci. Abstr. (2007)
26. Rhodes M.E., and Frye C.A. Estrogen has mnemonic-enhancing effects in the inhibitory avoidance task. Pharm. Biochem. Behav. 78 (2004) 551-558
27. Sandstrom N.J., and Williams C.L. Memory retention is modulated by acute estradiol and progesterone replacement. Behav. Neurosci. 115 (2001) 384-393
28. Sato T., Tanaka K., Ohnishi Y., Teramoto T., Irifune M., and Nishikawa T. Effects of estradiol and progesterone on radial maze performance in middle-aged female rats fed a low-calcium diet. Behav. Brain Res. 150 (2004) 33-42
29. Sherwin B.B., and Henry J.F. Brain aging modulates the neuroprotective effects of estrogen on selective aspects of cognition in women: a critical review. Front Neuroendocrinol. 29 (2008) 88-113
30. Singh M. Progestins and neuroprotection: are all progestins created equal?. Minerva Endocrinol. 32 (2007) 95-102
31. Smith C.D., Wekstein D.R., Markesbery W.R., and Frye C.A. 3α,5α-THP: a potential plasma neurosteroid biomarker in Alzheimer's disease and perhaps non-Alzheimer's dementia. Psychopharmacology 18 (2005) 1-5
32. Solis-Ortiz S., Guevara M.A., and Corsi-Cabrera M. Performance in a test demanding prefrontal functions is favored by early luteal phase progesterone: an electroencephalographic study. Psychoneuroendocrinology 29 (2004) 1047-1057
33. K. Sumida, C.A. Frye, Progesterone attenuates depressive behavior of young, old and progesterone receptor knock out mice, Horm. Behav. (in revision).
34. van Wingen G., van Broekhoven F., Verkes R.J., Petersson K.M., Bäckström T., Buitelaar J., and Fernández G. How progesterone impairs memory for biologically salient stimuli in healthy young women. J. Neurosci. 27 (2007) 11416-11423
35. Voigt L.F., Weiss N.S., Chu J., Daling J.R., McKnight B., and van Belle G. Progestagen supplementation of exogenous oestrogens and risk of endometrial cancer. Lancet 338 (1991) 274-277
36. Vongher J.M., and Frye C.A. Progesterone in conjunction with estradiol has neuroprotective effects in an animal model of neurodegeneration. Pharmacol. Biochem. Behav. 64 (1999) 777-785
37. A.A. Walf, C. Koonce, C.A. Frye, Estrogen or diarylpropionitrile administration to wildtype, but not estrogen receptor beta knockout, mice enhances performance in the object recognition and object placement tasks, Neurobiol. Learn. Mem., in press.
38. Walf A.A., Rhodes M.E., Meade J.R., Harney J.P., and Frye C.A. Estradiol-induced conditioned place preference may require actions at estrogen receptors in the nucleus accumbens. Neuropsychopharmacology 32 (2007) 522-530
39. Walf A.A., Rhodes M.E., and Frye C.A. Ovarian steroids enhance object recognition in naturally cycling and ovariectomized, hormone-primed rats. Neurobiol. Learn. Mem. 86 (2006) 35-46
40. Whitehead M. The effects of oestrogens and progestogens on the postmenopausal endometrium. Maturitas 1 (1978) 87-98
41. Wood G.E., Beylin A.V., and Shors T.J. The contribution of adrenal and reproductive hormones to the opposing effects of stress on trace conditioning in males versus females. Behav. Neurosci. 115 (2001) 175-187
42. Cache County Memory Study Investigators. Hormone replacement therapy and the incidence of Alzheimers disease in older women: the Cache County Study. JAMA 288 (2002) 2123-2129