Palliative chemotherapy in elderly patients with common metastatic malignancies: A Hellenic Cooperative Oncology Group registry analysis of management, outcome and clinical benefit predictors

Critical Reviews in Oncology/Hematology

Volumn 66, Issue 3, 2008, Pages 237-247

  Pentheroudakis, George ^a   Fountzilas, George ^b   Kalofonos, Haralabos P ^c   Golfinopoulos, Vassilios ^a   Aravantinos, Gerasimos ^d   Bafaloukos, Dimitrios ^e   Papakostas, Pavlos ^f   Pectasides, Dimitrios ^g   Christodoulou, Christos ^h   Syrigos, Konstantinos ⁱ   Economopoulos, Theofanis ^g   Pavlidis, Nicholas ^a  

^a UNIVERSITY HOSPITAL OF IOANNINA   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^c UNIVERSITY HOSPITAL OF PATRAS   (Greece)

^d AGII ANARGIRI CANCER HOSPITAL   (Greece)

^e METROPOLITAN HOSPITAL   (Greece)

^f HIPPOKRATION HOSPITAL   (Greece)

^g NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^h HENRY DUNANT HOSPITAL   (Greece)

ⁱ SOTIRIA GENERAL HOSPITAL   (Greece)

Author keywords

Breast cancer; Chemotherapy; Colorectal cancer; Elderly; Lung cancer; Metastases

Indexed keywords

ALBUMIN; ANTHRACYCLINE DERIVATIVE; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; CREATININE; FLUOROPYRIMIDINE DERIVATIVE; GEMCITABINE; GRANULOCYTE COLONY STIMULATING FACTOR; HEMOGLOBIN; IRINOTECAN; NAVELBINE; OXALIPLATIN; PLATINUM DERIVATIVE; TAXANE DERIVATIVE;

ADVANCED CANCER; AGED; ALBUMIN BLOOD LEVEL; ALOPECIA; ANEMIA; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BONE MARROW SUPPRESSION; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER PALLIATIVE THERAPY; CANCER REGISTRY; CARDIOTOXICITY; COLORECTAL CANCER; CREATININE BLOOD LEVEL; DIARRHEA; DRUG DOSE REDUCTION; DRUG HYPERSENSITIVITY; DRUG WITHDRAWAL; ELDERLY CARE; FATIGUE; FEBRILE NEUTROPENIA; FEMALE; FEVER; HEMOGLOBIN BLOOD LEVEL; HUMAN; LOGISTIC REGRESSION ANALYSIS; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; METASTASIS; MONOTHERAPY; MUCOSA INFLAMMATION; NAUSEA; NEUROTOXICITY; NEUTROPENIA; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PAIN; PREDICTION; PROGNOSIS; REVIEW; THROMBOCYTOPENIA; VOMITING;

AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; COLORECTAL NEOPLASMS; COMORBIDITY; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; NEOPLASM METASTASIS; PALLIATIVE CARE; TREATMENT OUTCOME;

EID: 42749084831     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2007.12.003     Document Type: Review

References (32)

1. Balducci L., and Ershler W.B. Cancer and ageing: a nexus at several levels. Nat Rev Cancer 5 (2005) 655-662
2. Edwards B.K., Howe H.L., Ries L.A., et al. Annual report to the nation on the status of cancer 1973-1999, featuring implications of age and ageing on US cancer burden. Cancer 94 (2002) 2766-2792
3. Gosney M.A. Clinical assessment of elderly people with cancer. Lancet Oncol 6 (2005) 790-797
4. Extermann M., Aapro M., Bernabei R., et al. Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG). Crit Rev Oncol Hematol 55 (2005) 241-252
5. Repetto L., Venturino A., Fratino L., et al. Geriatric oncology: a clinical approach to the older patient with cancer. Eur J Cancer 39 (2003) 870-880
6. Balducci L., and Extermann M. Management of cancer in the older person: a practical approach. Oncologist 5 (2000) 224-237
7. Chen H., Cantor A., Meyer J., et al. Can older cancer patients tolerate chemotherapy? A prospective pilot study. Cancer 97 (2003) 1107-1114
8. Trotti A., Colevas A.D., Setser A., et al. CTC-AE version 3.0: development of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol 13 (2003) 176-181
9. Kaplan E.L., and Meier P. Non parametric estimation from incomplete observations. J Am Stat Assoc 53 (1958) 457-481
10. Stuck A.E., Siu A.L., Wieland G.D., Adams J., and Rubenstein L.Z. Comprehensive geriatric assessment: a meta-analysis of controlled trials. Lancet 342 (1993) 1032-1036
11. Overcash J.A., Beckstead J., Extermann M., and Cobb S. The abbreviated comprehensive geriatric assessment (aCGA): a retrospective analysis. Crit Rev Oncol Hematol 54 (2005) 129-136
12. Extermann M., Chen H., Cantor A.B., et al. Predictors of tolerance to chemotherapy in older cancer patients: a prospective pilot study. Eur J Cancer 38 (2002) 1466-1473
13. Hamberg P., Verweij J., and Seynaeve C. Cytotoxic chemotherapy for the elderly with metastatic breast cancer: a review on safety, pharmacokinetics and efficacy. Eur J Cancer 43 (2007) 1514-1528
14. Golfinopoulos V., Pentheroudakis G., and Pavlidis N. Treatment of colorectal cancer in the elderly: a review of the literature. Cancer Treat Rev 32 (2006) 1-8
15. Gridelli C., Langer C., Maione P., Rossi A., and Schild S.E. Lung cancer in the elderly. J Clin Oncol 25 (2007) 1898-1907
16. Gridelli C., Perrone F., Gallo C., et al. Chemotherapy for elderly patients with advanced non-small cell lung cancer: The Multi-Center Italian Lung Cancer in the Elderly Study (MILES) phase III randomised trial. J Natl Cancer Inst 95 (2003) 362-372
17. Frasci G., Lorusso V., Panza N., et al. Gemcitabine plus vinorelbine versus vinorelbine alone in elderly patients with advanced non-small cell lung cancer. J Clin Oncol 18 (2000) 2529-2536
18. Minami H., Ohe Y., Niho S., et al. Comparison of pharmacokinetics and pharmacodynamics of docetaxel and cisplatin in elderly and non-elderly patients: why is toxicity increased in elderly patients?. J Clin Oncol 22 (2004) 2901-2908
19. Langer C.J., Vangel M., Schiller J., et al. Age-specific subanalysis of ECOG 1594 fit elderly patients (70-80 years) with NSCLC do as well as younger patients (<70 years). Proc Am Soc Clin Oncol 22 (2003) 639 [abstr. 2571]
20. Christman K., Muss H.B., Case L.D., and Stanley V. Chemotherapy of metastatic breast cancer in the elderly. The piedmont oncology association experience. JAMA 268 (1992) 57-62
21. Sastre J., Marcuello E., Massuti B., et al. Irinotecan in combination with fluorouracil in a 48-h continuous infusion as first-line chemotherapy for elderly patients with metastatic colorectal cancer: a Spanish Cooperative Group or the Treatment of Digestive Tumours Study. J Clin Oncol 23 (2005) 3545-3551
22. Buzzi F., Natale D., Farris A., et al. Capecitabine plus oxaliplatin tailored regimen for the first-line treatment of elderly patients with metastatic colorectal cancer. Final results of the SIGOG trial 0108. Proc Am Soc Clin Oncol (2005) 266s
23. Folprecht G., Cunningham D., Ross P., et al. Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: a pooled analysis of clinical trials. Ann Oncol 15 (2004) 1330-1338
24. Jemal A., Siegel R., Ward E., et al. Cancer statistics 2006. CA Cancer J Clin 56 (2006) 106-130
25. Silber J.H., Fridman M., Di Paola R.S., et al. First-cycle blood counts and subsequent neutropenia, dose-reduction or delay in early-stage breast cancer therapy. J Clin Oncol 16 (1998) 2392-2400
26. Ray-Coquard I., Le Cesne A., Rubio M.T., et al. Risk model for severe anemia requiring red blood cell transfusion after cytotoxic conventional chemotherapy regimens. J Clin Oncol 17 (1999) 2840-2846
27. Voog E., Bienvenu J., Warzocha K., et al. Factors that predict chemotherapy-induced myelosuppression in lymphoma patients: role of the TNF ligand-receptor system. J Clin Oncol 18 (2000) 325-331
28. Intragumtornchai T., Sutheesophon J., Sutcharitchan P., and Swasdikul D. A predictive model for life-threatening neutropenia and febrile neutropenia after the first course of CHOP chemotherapy in patients with aggressive non-Hodgkin's lymphoma. Leukemia Lymphoma 37 (2000) 351-360
29. Walter L.C., Brand R.J., Counsell S.R., et al. Development and validation of a prognostic index for 1-year mortality in older adults after hospitalisation. JAMA 285 (2001) 2987-2994
30. Corti M.C., Guralnik J.M., Salive M.E., et al. Serum albumin level and physical disability as predictors of mortality in older persons. JAMA 272 (1994) 1036-1042
31. Kikuchi M., Inagaki T., and Shinagawa N. Five-year survival of older people with anemia: variation with hemoglobin concentration. J Am Geriatr Soc 49 (2001) 1226-1228
32. Penninx B.W., Guralnik J.M., Onder G., et al. Anemia and decline in physical performance among older persons. Am J Med 115 (2003) 104-110