RNA interference shows interactions between mouse brainstem angiotensin AT1 receptors and angiotensin-converting enzyme 2

Experimental Physiology

Volumn 93, Issue 5, 2008, Pages 676-684

  Lin, Zhanyi ^a,b   Chen, Yanfang ^a   Zhang, Wenfeng ^a   Chen, Alex F ^c   Lin, Shuguang ^b   Morris, Mariana ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

^b GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN CONVERTING ENZYME 2; SHORT HAIRPIN RNA;

ANIMAL TISSUE; ARTICLE; BRAIN STEM; CONTROLLED STUDY; DOWN REGULATION; GENE SILENCING; IMMUNOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RNA INTERFERENCE;

EID: 42649144125     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2007.041657     Document Type: Article

References (53)

1. Alexiou T, Boon WM, Denton DA, Nicolantonio RD, Walker LL, McKinley MJ & Campbell DJ (2005). Angiotensinogen and angiotensin‐converting enzyme gene copy number and angiotensin and bradykinin peptide levels in mice. J Hypertens 23, 945–954.
2. Alvarez VA, Ridenour DA & Sabatini BL (2006). Retraction of synapses and dendritic spines induced by off‐target effects of RNA interference. J Neurosci 26, 7820–7825.
3. Bantounas I, Phylactou LA & Uney JB (2004). RNA interference and the use of small interfering RNA to study gene function in mammalian systems. J Mol Endocrinol 33, 545–557.
4. Becker LK, Etelvino GM, Walther T, Santos RA & Campagnole‐Santos MJ (2007). Immunofluorescence localization of the receptor Mas in cardiovascular‐related areas of the rat brain. Am J Physiol Heart Circ Physiol 293, H1416–H1424.
5. Block CH, Santos RA, Brosnihan KB & Ferrario CM (1988). Immunocytochemical localization of angiotensin‐(1–7) in the rat forebrain. Peptides 9, 1395–401.
6. Burson JM, Aguilera G, Gross KW & Sigmund CD (1994). Differential expression of angiotensin receptor 1A and 1B in mouse. Am J Physiol Endocrinol Metab 267, E260–E267.
7. Campbell DJ, Alexiou T, Xiao HD, Fuchs S, McKinley MJ, Corvol P & Bernstein KE (2004). Effect of reduced angiotensin‐converting enzyme gene expression and angiotensin‐converting enzyme inhibition on angiotensin and bradykinin peptide levels in mice. Hypertension 43, 854–859.
8. Chai SY, Mendelsohn FA & Paxinos G (1987). Angiotensin converting enzyme in rat brain visualized by quantitative in vitro autoradiography. Neuroscience 20, 615–27.
9. Chappell MC, Brosnihan KB, Diz DI & Ferrario CM (1989). Identification of angiotensin‐(1–7) in rat brain. Evidence for differential processing of angiotensin peptides. J Biol Chem 264, 16518–16523.
10. Chen Y, Chen H, Hoffmann A, Cool DR, Diz DI, Chappell MC, Chen A & Morris M (2006). Adenovirus‐mediated small‐interference RNA for in vivo silencing of angiotensin AT1a receptors in mouse brain. Hypertension 47, 230–237.
11. Chen Y, Da Rocha MJ & Morris M (2003). Osmotic regulation of angiotensin AT1 receptor subtypes in mouse brain. Brain Res 965, 35–44.
12. Chen Y, Liu‐Stratton Y, Hassanain H, Cool DR & Morris M (2004). Dietary sodium regulates angiotensin AT1a and AT1b mRNA expression in mouse brain. Exp Neurol 188, 238–245.
13. Chen Y & Morris M (2001). Differentiation of brain angiotensin type 1a and 1b receptor mRNAs: a specific effect of dehydration. Hypertension 37, 692–697.
14. Culman J, Hohle S, Qadri F, Edling O, Blume A, Lebrun C & Unger T (1995). Angiotensin as neuromodulator/neurotransmitter in central control of body fluid and electrolyte homeostasis. Clin Exp Hypertens 17, 281–293.
15. Davidson BL, Allen ED, Kozarsky KF, Wilson JM & Roessler BJ (1993). A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nat Genet 3, 219–223.
16. Davisson RL, Oliverio MI, Coffman TM & Sigmund CD (2000). Divergent functions of angiotensin II receptor isoforms in the brain. J Clin Invest 106, 103–106.
17. Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE & Acton S (2000). A novel angiotensin‐converting enzyme‐related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1–9. Circ Res 87, E1–E9.
18. Doobay MF, Talman LS, Obr TD, Tian X, Davisson RL & Lazartigues E (2007). Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin‐angiotensin system. Am J Physiol Regul Integr Comp Physiol 292, R373–R381.
19. Elased KM, Cunha TS, Marcondes FK & Morris M (2008). Brain angiotensin converting enzymes: role of angiotensin‐converting enzyme 2 in processing angiotensin II in mice. Exp Physiol ; DOI: DOI: 10.1113/expphysiol.2007.040311.
20. Elbashir SM, Harborth J, Weber K & Tuschl T (2002). Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 26, 199–213.
21. Ferrario CM, Jessup J, Gallagher PE, Averill DB, Brosnihan KB, Ann TE, Smith RD & Chappell MC (2005). Effects of renin‐angiotensin system blockade on renal angiotensin‐(1–7) forming enzymes and receptors. Kidney Int 68, 2189–2196.
22. Gallagher PE, Chappell MC, Ferrario CM & Tallant EA (2006). Distinct roles for ANG II and ANG‐(1–7) in the regulation of angiotensin‐converting enzyme 2 in rat astrocytes. Am J Physiol Cell Physiol 290, C420–C426.
23. Glass MJ, Huang J, Speth RC, Iadecola C & Pickel VM (2005). Angiotensin II AT‐1A receptor immunolabeling in rat medial nucleus tractus solitarius neurons: subcellular targeting and relationships with catecholamines. Neuroscience 130, 713–723.
24. Igase M, Strawn WB, Gallagher PE, Geary RL & Ferrario CM (2005). Angiotensin II AT 1 receptors regulate ACE2 and angiotensin‐(1–7) expression in the aorta of spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 289, H1013–H1019.
25. Ishiyama Y, Gallagher PE, Averill DB, Tallant EA, Brosnihan KB & Ferrario CM (2004). Upregulation of angiotensin‐converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors. Hypertension 43, 970–976.
26. Johren O, Imboden H, Hauser W, Maye I, Sanvitto GL & Saavedra JM (1997). Localization of angiotensin‐converting enzyme, angiotensin II, angiotensin II receptor subtypes, and vasopressin in the mouse hypothalamus. Brain Res 757, 218–227.
27. Johren O, Inagami T & Saavedra JM (1995). AT1A, AT1B, and AT2 angiotensin II receptor subtype gene expression in rat brain. Neuroreport 6, 2549–2552.
28. Kakar SS, Riel KK & Neill JD (1992). Differential expression of angiotensin II receptor subtype mRNAs (AT‐1A and AT‐1B) in the brain. Biochem Biophys Res Commun 185, 688–692.
29. Key M, Wirick B, Cool D & Morris M (2001). Quantitative in situ hybridization for peptide mRNAs in mouse brain. Brain Res Brain Res Protoc 8, 8–15.
30. Kitamura T, Feng Y, Kitamura YI, Chua SC Jr, Xu AW, Barsh GS, Rossetti L & Accili D (2006). Forkhead protein FoxO1 mediates Agrp‐dependent effects of leptin on food intake. Nat Med 12, 534–540.
31. Krob HA, Vinsant SL, Ferrario CM & Friedman DP (1998). Angiotensin‐(1–7) immunoreactivity in the hypothalamus of the (mRen‐2d)27 transgenic rat. Brain Res 798, 36–45.
32. Lavoie JL, Cassell MD, Gross KW & Sigmund CD (2004). Localization of renin expressing cells in the brain, by use of a REN‐eGFP transgenic model. Physiol Genomics 16, 240–246.
33. Lazartigues E, Dunlay SM, Loihl AK, Sinnayah P, Lang JA, Espelund JJ, Sigmund CD & Davisson RL (2002). Brain‐selective overexpression of angiotensin (AT 1) receptors causes enhanced cardiovascular sensitivity in transgenic mice. Circ Res 90, 617–624.
34. Lenkei Z, Palkovits M, Corvol P & Llorens‐Cortes C (1996). Distribution of angiotensin II type‐2 receptor (AT2) mRNA expression in the adult rat brain. J Comp Neurol 373, 322–339.
35. Lind RW, Swanson LW & Ganten D (1984). Angiotensin II immunoreactive pathways in the central nervous system of the rat: evidence for a projection from the subfornical organ to the paraventricular nucleus of the hypothalamus. Clin Exp Hypertens A 6, 1915–1920.
36. McKinley MJ, Albiston AL, Allen AM, Mathai ML, May CN, McAllen RM, Oldfield BJ, Mendelsohn FA & Chai SY (2003). The brain renin‐angiotensin system: location and physiological roles. Int J Biochem Cell Biol 35, 901–918.
37. Makimura H, Mizuno TM, Mastaitis JW, Agami R & Mobbs CV (2002). Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake. BMC Neurosci 3, 18.
38. Northcutt C, Watts S, Morris M, Chen Y, Chen A & Haywood JR (2007). Adenoviral inhibition of AT1a receptors in the paraventricular nucleus inhibits acute increases in mean arterial blood pressure in the rat. Hypertension 50, E77.
39. Oliverio MI, Best CF, Smithies O & Coffman TM (2000a). Regulation of sodium balance and blood pressure by the AT 1A receptor for angiotensin II. Hypertension 35, 550–554.
40. Oliverio MI, Delnomdedieu M, Best CF, Li P, Morris M, Callahan MF, Johnson GA, Smithies O & Coffman TM (2000b). Abnormal water metabolism in mice lacking the type 1A receptor for ANG II. Am J Physiol Renal Physiol 278, F75–F82.
41. Paul M, Poyan MA & Kreutz R (2006). Physiology of local renin‐angiotensin systems. Physiol Rev 86, 747–803.
42. Phillips MI, Speakman EA & Kimura B (1993). Levels of angiotensin and molecular biology of the tissue renin angiotensin systems. Regul Peptides 43, 1–20.
43. Rocha MJ, Chen Y, Oliveira GR & Morris M (2005). Physiological regulation of brain angiotensin receptor mRNA in AT1a deficient mice. Exp Neurol 195, 229–235.
44. Sakima A, Averill DB, Gallagher PE, Kasper SO, Tommasi EN, Ferrario CM & Diz DI (2005). Impaired heart rate baroreflex in older rats: role of endogenous angiotensin‐(1–7) at the nucleus tractus solitarii. Hypertension 46, 333–340.
45. Senador D, Farah V, Chen H, Chen AF, Morris M & Chen Y (2006). In vivo siRNA silencing of brainstem angiotensin AT1a mRNA alters autonomic balance in mice. FASEB J 20, A364.
46. Sinnayah P, Lindley TE, Staber PD, Cassell MD, Davidson BL & Davisson RL (2002). Selective gene transfer to key cardiovascular regions of the brain: comparison of two viral vector systems. Hypertension 39, 603–608.
47. Sinnayah P, Lindley TE, Staber PD, Davidson BL, Cassell MD & Davisson RL (2004). Targeted viral delivery of Cre recombinase induces conditional gene deletion in cardiovascular circuits of the mouse brain. Physiol Genomics 18, 25–32.
48. Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G & Turner AJ (2000). A human homolog of angiotensin‐converting enzyme. Cloning and functional expression as a captopril‐insensitive carboxypeptidase. J Biol Chem 275, 33238–33243.
49. Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, Godbout K, Parsons T, Baronas E, Hsieh F, Acton S, Patane M, Nichols A & Tummino P (2002). Hydrolysis of biological peptides by human angiotensin‐converting enzyme‐related carboxypeptidase. J Biol Chem 277, 14838–14843.
50. Wall NR & Shi Y (2003). Small RNA: can RNA interference be exploited for therapy? Lancet 362, 1401–1403.
51. Yamazato M, Yamazato Y, Sun C, Diez‐Freire C & Raizada MK (2007). Overexpression of angiotensin‐converting enzyme 2 in the rostral ventrolateral medulla causes long‐term decrease in blood pressure in the spontaneously hypertensive rats. Hypertension 49, 926–931.
52. Zhou Y, Dirksen WP, Chen Y, Morris M, Zweier JL & Periasamy M (2005). A major role for AT 1b receptor in mouse mesenteric resistance vessels and its distribution in heart and neuroendocrine tissues. J Mol Cell Cardiol 38, 693–696.
53. Zhuo J, Moeller I, Jenkins T, Chai SY, Allen AM, Ohishi M & Mendelsohn FA (1998). Mapping tissue angiotensin‐converting enzyme and angiotensin AT1, AT2 and AT4 receptors. J Hypertens 16, 2027–2037.