Mucosal intraepithelial T-lymphocytes in refractory celiac disease: A neoplastic population with a variable CD8 phenotype

American Journal of Surgical Pathology

Volumn 32, Issue 5, 2008, Pages 744-751

  De Mascarel, Antoine ^a   Belleannée, Geneviève ^b   Stanislas, Sophie ^b   Merlio, Christine ^b   Parrens, Marie ^b   Laharie, David ^b   Dubus, Pierre ^b   Merlio, Jean Philippe ^b  

^a HAUT LÉVÊQUE HOSPITAL   (France)

^b NONE

Author keywords

Enteropathy type associated T cell lymphoma; Refractory celiac disease; T cell receptor gene rearrangement

Indexed keywords

CD3 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ADOLESCENT; ADULT; AGED; ARTICLE; CELIAC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENTEROPATHY; FEMALE; GENE REARRANGEMENT; GLUTEN FREE DIET; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; T CELL LYMPHOMA; T LYMPHOCYTE;

ADOLESCENT; ADULT; AGED; ANTIGENS, CD3; ANTIGENS, CD8; CELIAC DISEASE; CLONE CELLS; DNA; FEMALE; GENES, T-CELL RECEPTOR BETA; HUMANS; IMMUNOENZYME TECHNIQUES; INTESTINAL MUCOSA; INTESTINAL NEOPLASMS; LYMPHOMA, T-CELL; MALE; MIDDLE AGED; PROGNOSIS; T-LYMPHOCYTES; TUMOR MARKERS, BIOLOGICAL;

EID: 42649133815     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318159b478     Document Type: Article

References (24)

1. Alfsen GC, Beiske K, Bell H, et al. Low-grade intestinal lymphoma of intraepithelial T lymphocytes with concomitant enteropathy-associated T cell lymphoma: case report suggesting a possible histogenetic relationship. Hum Pathol. 1989;20:909-913.
2. Ashton-Key M, Diss TC, Pan PX, et al. Molecular analysis of T-cell clonality in ulcerative jejunitis and enteropathy associated T-cell lymphoma. Am J Pathol. 1997;151:493.
3. Bagdi E, Diss TC, Munson P, et al. Mucosal intra-epithelial lymphocytes in enteropathy-associated T-cell lymphoma, ulcerative jejunitis, and refractory celiac disease constitute a neoplastic population. Blood. 1999;94:260-264.
4. Beylot-Barry M, Sibaud V, Thiebaut R, et al. Evidence that an identical T cell clone in skin and peripheral blood lymphocytes is an independent prognostic factor in primary cutaneous T cell lymphomas. J Invest Dermatol. 2001;117:920-926.
5. Bishton MJ, Haynes AP, Byrne JL, et al. Treatment of enteropathy associated T-cell lymphoma with combination chemotherapy followed by autologous stem cell transplantation. Blood. 2006; 108(suppl 2):450B-451B.
6. Campo E, Chott A, Kinney MC, et al. Update on extranodal lymphomas. Conclusions of the workshop held by the EAHP and the SH in Thessaloniki, Greece. Histopathology. 2006;48:481-504.
7. Carbonnel F, Grollet-Bioul L, Brouet JC, et al. Are complicated forms of celiac disease cryptic T-cell lymphomas? Blood. 1998;92: 3879.
8. Carey MJ, Medeiros LJ, Roepke JE, et al. Primary anaplastic large cell lymphoma of the small intestine. Am J Clin Pathol. 1999; 112:696-701.
9. Cellier C, Patey N, Mauvieux L, et al. Abnormal intestinal intraepithelial lymphocytes in refractory sprue. Gastroenterology. 1998;114:471.
10. Chott A, Haedicke W, Mosberger I, et al. Most CD56+ intestinal lymphomas are CD8+ CD5- T-cell lymphomas of monomorphic small to medium size histology. Am J Pathol. 1998;153: 1483-1490.
11. Daum S, Weiss D, Hummel M, et al. Frequency of clonal intraepithelial T lymphocyte proliferations in enteropathy-type intestinal T cell lymphoma, coeliac disease, and refractory sprue. Gut. 2001;49:804-812.
12. Daum S, Ullrich R, Heise W, et al. Intestinal non-Hodgkin's lymphoma: a multicenter prospective clinical study group on intestinal non-Hodgkin's lymphoma. J Clin Oncol. 2003;21:2740-2746.
13. de Mascarel A, Dubus P, Belleannée G, et al. Low prevalence of monoclonal B cells in Helicobacter pylori gastritis patients with duodenal ulcer. Hum Pathol. 1998;29:784-790.
14. de Mascarel A, Ruskone-Fourmestraux A, Lavergne-Slove A, et al. Clinical, histological and molecular follow-up of 60 patients with gastric marginal zone lymphoma of mucosa-associated lymphoid tissue. Virchows Arch. 2005;446:219-224.
15. Domizio P, Owen RA, Shepherd NA, et al. Primary lymphoma of the small intestine. A clinico-pathological study of 119 cases. Am J Surg Pathol. 1993;17:429-442.
16. Egan LJ, Walsh SV, Stevens FM, et al. Celiac-associated lymphoma. A single institution experience of 30 cases in the combination chemotherapy era. J Clin Gastroenterol. 1995;21:123-129.
17. Foucar K, Foucar E, Mitros F, et al. Epitheliotropic lymphoma of the small bowel. Report of a fatal case with cytotoxic/suppressor T-cell immunophenotype. Cancer. 1984;54:54-60.
18. Gale J, Simmonds PD, Mead GM, et al. Enteropathy-type intestinal t-cell lymphoma: clinical features and treatment of 31 patients in a single center. J Clin Oncol. 2000;18:795-803.
19. Isaacson PG, Du MQ. Gastrointestinal lymphoma: where morphology meets molecular biology. J Pathol. 2005;205:255-274.
20. Liu H, Brais R, Payne K, et al. Immunophenotyping and clonality analysis in diagnosis of refractory celiac disease. Lab Invest. 2006;86(suppl 1):235A.
21. Patey-Mariaud de Serre N, Cellier C, Jabri B, et al. Distinction between coeliac disease and refractory sprue: a simple immunohistochemical method. Histopathology. 2000;37:70-77.
22. Rucker-Schmidt RL, Pinkus GS, Pinkus JL, et al. The majority of intraepithelial T cells in celiac disease are CD5 negative: an extensive immunohistochemical analysis. Lab Invest. 2006;86(suppl l): 118A.
23. Spencer J, Cerf-Bensussan N, Jarry A, et al. Enteropathy associated T-cell lymphoma (malignant histiocytosis of the intestine) is recognized by a monoclonal antibody (HML1) that defines a membrane molecular on human mucosal lymphocytes. Am J Pathol. 1988;132:1-5.
24. Verkarre V, Asnafi V, Lecomte T, et al. Refractory coeliac sprue is a diffuse gastrointestinal disease. Gut. 2003;52:205-211.