Clinicopathologic and molecular features of sporadic microsatellite- and chromosomal-stable colorectal cancers

International Journal of Colorectal Disease

Volumn 23, Issue 4, 2008, Pages 365-373

  Cai, Guoxiang ^a   Xu, Ye ^a   Lu, Hongfen ^a   Shi, Yingqiang ^a   Lian, Peng ^a   Peng, Junjie ^a   Du, Xiang ^a   Zhou, Xiaoyan ^a   Guan, Zuqing ^a   Shi, Daren ^a   Cai, Sanjun ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Colorectal neoplasms; Diploid; Epigenetics; Microsatellite stable; Sporadic

Indexed keywords

APC PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN BAX; PROTEIN DERIVATIVE; PROTEIN MINT1; PROTEIN MLH1; PROTEIN P53;

ADULT; ARTICLE; CANCER CLASSIFICATION; CANCER LOCALIZATION; CHROMOSOMAL INSTABILITY; CLINICAL FEATURE; COLORECTAL CANCER; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EPIGENETICS; FEMALE; GENE EXPRESSION PROFILING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MOLECULAR GENETICS; PHENOTYPIC VARIATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; TUMOR DIFFERENTIATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BCL-2-ASSOCIATED X PROTEIN; CHROMOSOMAL INSTABILITY; COLORECTAL NEOPLASMS; DIPLOIDY; DNA METHYLATION; DNA REPAIR; DNA, NEOPLASM; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; NEOPLASM STAGING; NUCLEAR PROTEINS; PHENOTYPE; POLYMERASE CHAIN REACTION;

EID: 42649126002     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-007-0423-7     Document Type: Article

References (38)

1. Stoler DL, Chen N, Basik M, Kahlenberg MS, Rodriguez-Bigas MA, Petrelli NJ et al (1999) The onset and extent of genomic instability in sporadic colorectal tumor progression. Proc Natl Acad Sci USA 96:15121-15126
2. Goel A, Arnold CN, Niedzwiecki D, Chang DK, Ricciardiello L, Carethers JM et al (2003) Characterization of sporadic colon cancer by patterns of genomic instability. Cancer Res 63:1608-1614
3. Tang R, Changchien CR, Wu MC, Fan CW, Liu KW, Chen JS et al (2004) Colorectal cancer without high microsatellite instability and chromosomal instability - an alternative genetic pathway to human colorectal cancer. Carcinogenesis 25:841-846
4. Dunican DS, McWilliam P, Tighe O, Parle-McDermott A, Croke DT (2002) Gene expression differences between the microsatellite instability (MIN) and chromosomal instability (CIN) phenotypes in colorectal cancer revealed by high-density cDNA array hybridization. Oncogene 21:3253-3257
5. Haydon AM, Jass JR (2002) Emerging pathways in colorectal-cancer development. Lancet Oncol 3:83-88
6. Wheeler JM, Bodmer WF, Mortensen NJ (2004) DNA mismatch repair genes and colorectal cancer. Gut 47:148-153
7. Jones AM, Douglas EJ, Halford SE, Fiegler H, Gorman PA, Roylance RR et al (2005) Array-CGH analysis of microsatellite-stable, near-diploid bowel cancers and comparison with other types of colorectal carcinoma. Oncogene 24:118-129
8. Hawkins NJ, Tomlinson I, Meagher A, Ward RL (2001) Microsatellite-stable diploid carcinoma: A biologically distinct and aggressive subset of sporadic colorectal cancer. Br J Cancer 84:232-236
9. Yao J, Eu KW, Seow-Choen F, Vijayan V, Cheah PY (1999) Microsatellite instability and aneuploidy rate in young colorectal-cancer patients do not differ significantly from those in older patients. Int J Cancer 80:667-670
10. Georgiades IB, Curtis LJ, Morris RM, Bird CC, Wyllie AH (1999) Heterogeneity studies identify a subset of sporadic colorectal cancers without evidence for chromosomal or microsatellite instability. Oncogene 18:7933-7940
11. Chan TL, Curtis LC, Leung SY, Farrington SM, Ho JW, Chan AS et al (2001) Early-onset colorectal cancer with stable microsatellite DNA and near-diploid chromosomes. Oncogene 20:4871-4876
12. Mori S, Ogata Y, Shirouzu K (2004) Biological features of sporadic colorectal carcinoma with high-frequency microsatellite instability: special reference to tumor proliferation and apoptosis. Int J Clin Oncol 9:322-329
13. Jubb AM, Bell SM, Quirke P (2001) Methylation and colorectal cancer. J Pathol 195:111-134
14. Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JP (1999) CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA 96:8681-8686
15. Umar A, Boland CR, Terdiman JP, Syngal S, de la Chapelle A, Ruschoff J et al (2004) Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 96:261-268
16. Sasaki K, Hashimoto T, Kawachino K, Takahashi M (1988) Intratumoral regional differences in DNA ploidy of gastrointestinal carcinomas. Cancer 62:2569-2575
17. Ormerod MG, Tribukait B, Giaretti W (1998) Consensus report of the task force on standardisation of DNA flow cytometry in clinical pathology. DNA Flow Cytometry Task Force of the European Society for Analytical Cellular Pathology. Anal Cell Pathol 17:103-110
18. Xu XL, Yu J, Zhang HY, Sun MH, Gu J, Du X et al (2004) Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. World J Gastroenterol 10:3441-3454
19. Yu J, Ni M, Xu J, Zhang H, Gao B, Gu J et al (2002) Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis. BMC Cancer 2:29
20. Xing EP, Nie Y, Song Y, Yang GY, Cai YC, Wang LD et al (1999) Mechanisms of inactivation of p14ARF, p15INK4b, and p16INK4a genes in human esophageal squamous cell carcinoma. Clin Cancer Res 5:2704-2713
21. Deng G, Chen A, Hong J, Chae HS, Kim YS (1999) Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression. Cancer Res 59:2029-2033
22. Yamamoto H, Itoh F, Nakamura H, Fukushima H, Sasaki S, Perucho M et al (2001) Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability. Cancer Res 61:3139-3144
23. Rosas SL, Koch W, da Costa Carvalho MG, Wu L, Califano J, Westra W et al (2001) Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients. Cancer Res 61:939-942
24. Silva J, Silva JM, Dominguez G, Garcia JM, Cantos B, Rodriguez R et al (2003) Concomitant expression of p16INK4a and p14ARF in rimary breast cancer and analysis of inactivation mechanisms. J Pathol 199:289-297
25. Gutierrez MI, Siraj AK, Khaled H, Koon N, El-Rifai W, Bhatia K (2004) CpG island methylation in Schistosoma- and non-Schistosoma-associated bladder cancer. Mod Pathol 17:1268-1274
26. Esteller M, Toyota M, Sanchez-Cespedes M, Capella G, Peinado MA, Watkins DN et al (2000) Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res 60:2368-2371
27. Chiaravalli AM, Furlan D, Facco C, Tibiletti MG, Dionigi A, Casati B et al (2001) Immunohistochemical pattern of hMSH2/hMLH1 in familial and sporadic colorectal, gastric, endometrial and ovarian carcinomas with instability in microsatellite sequences. Virchows Arch 438:39-48
28. Gafa R, Maestri I, Matteuzzi M, Santini A, Ferretti S, Cavazzini L et al (2000) Sporadic colorectal adenocarcinomas with high-frequency microsatellite instability. Cancer 89:2025-2037
29. Kariola R, Abdel-Rahman WM, Ollikainen M, Butzow R, Peltomaki P, Nystrom M (2005) APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers Short communication. Fam Cancer 4:187-190
30. Jass JR, Walsh MD, Barker M, Simms LA, Young J, Leggett BA (2002) Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability. Eur J Cancer 38:858-866
31. Thibodeau SN, French AJ, Cunningham JM, Tester D, Burgart LJ, Roche PC et al (1998) Microsatellite instability in colorectal cancer: Different mutator phenotypes and the principal involvement of hMLH1. Cancer Res 58:1713-1718
32. Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed JC et al (1997) Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 275:967-969
33. van Rijnsoever M, Grieu F, Elsaleh H, Joseph D, Iacopetta B (2002) Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands. Gut 51:797-802
34. Rashid A, Shen L, Morris JS, Issa JP, Hamilton SR (2001) CpG island methylation in colorectal adenomas. Am J Pathol 159:1129-1135
35. Ward RL, Cheong K, Ku SL, Meagher A, O'Connor T, Hawkins NJ (2003) Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability. J Clin Oncol 21:3729-3736
36. Kim H, Kim YH, Kim SE, Kim NG, Noh SH, Kim H (2003) Concerted promoter hypermethylation of hMLH1, p16INK4A, and E-cadherin in gastric carcinomas with microsatellite instability. J Pathol 200:23-31
37. Toyota M, Ahuja N, Suzuki H, Itoh F, Ohe-Toyota M, Imai K et al (1999) Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. Cancer Res 59:5438-5442
38. Yamamoto H, Min Y, Itoh F, Imsumran A, Horiuchi S, Yoshida M et al (2002) Differential involvement of the hypermethylator phenotype in hereditary and sporadic colorectal cancers with high-frequency microsatellite instability. Genes Chromosomes Cancer 33:322-325