Gastric cancer and Helicobacter pylori: The bug, the host or the environment?

Postgraduate Medical Journal

Volumn 84, Issue 990, 2008, Pages 169-170

  Walker, Marjorie M ^a   Teare, Louise ^b   McNulty, Cliodna ^c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b BROOMFIELD HOSPITAL   (United Kingdom)

^c GLOUCESTERSHIRE ROYAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMORPHISM; EDITORIAL; GENOTYPE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HOST RESISTANCE; STOMACH CANCER;

ENVIRONMENT; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; STOMACH NEOPLASMS;

EID: 42649119121     PISSN: 00325473     EISSN: None     Source Type: Journal    
DOI: 10.1136/pgmj.2008.068346     Document Type: Editorial

References (11)

1. Malfertheiner P, Sipponen P, Naumann M, et al. Helicobacter pylori eradication has the potential to prevent gastric cancer: a state-of-the-art critique. Am J Gastroenterol 2005;100:2100-15.
2. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984;1:1311-15.
3. Parsonnet J, Friedman GD, Vandersteen DP, et al. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 1991;325:1127-31.
4. Amieva MR, El-Omar EM. Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology 2008;134:306-23.
5. Tiwari, Manoj G, Vasanth Kumar G, et al. Prognostic significance of genotyping Helicobacter pylori infection in patients in younger age groups with gastric cancer. Postgrad Med J 2008;84:193-7.
6. El-Omar EM, Carrington M, Chow WH, et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000;404:398-402.
7. Rad R, Prinz C, Neu B, et al. Synergistic effect of Helicobacter pylori virulence factors and interleukin-1 polymorphisms for the development of severe histological changes in the gastric mucosa. J Infect Dis 2003;188:272-81.
8. Correa P, Fontham ET, Bravo JC, et al. Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-Helicobacter pylori therapy. J Natl Cancer Inst 2000;92:1881- 8.
9. Houghton J, Wang TC. Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers. Gastroenterology 2005;128:1567-78.
10. Fock KM, Talley NJ, Fass R, et al. Asia-Pacific consensus on the management of gastroesophageal reflux disease: Update. Gastroenterol Hepatol 2008;23:8-22.
11. Wilson KT, Crabtree JE. Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies. Gastroenterology 2007;133:288-308.