The effects of candesartan on diabetes glomerulopathy: A double-blind, placebo-controlled trial

Pediatric Nephrology

Volumn 23, Issue 6, 2008, Pages 947-954

  Perrin, Nina E S S ^a   Jaremko, Georg A ^b   Berg, Ulla B ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b Division of Pathology ^*  (Sweden)

Author keywords

Blood pressure; Kidney biopsy; Kidney function test; Microalbuminuria; Normoalbuminuria; Type 1 diabetes

Indexed keywords

4 AMINOHIPPURIC ACID; CANDESARTAN; ENALAPRIL; INULIN; PLACEBO;

ADULT; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; ELECTRON MICROSCOPY; FEMALE; FOLLOW UP; GLOMERULOPATHY; GLOMERULUS FILTRATION RATE; HUMAN; HYPERTENSION; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY BIOPSY; KIDNEY CLEARANCE; KIDNEY FUNCTION TEST; KIDNEY PLASMA FLOW; MALE; MESANGIUM; MICROALBUMINURIA; MICROSCOPY; PRIORITY JOURNAL;

ADULT; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; BENZIMIDAZOLES; BIOPSY; BLOOD PRESSURE; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; DISEASE PROGRESSION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; KIDNEY; KIDNEY FUNCTION TESTS; MALE; PROSPECTIVE STUDIES; TETRAZOLES; TIME FACTORS; TREATMENT OUTCOME;

EID: 42649097582     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-008-0745-x     Document Type: Article

References (36)

1. Asao K, Sarti C, Forsen T, Hyttinen V, Nishimura R, Matsushima M, Reunanen A, Tuomilehto J, Tajima N (2003) Long-term mortality in nationwide cohorts of childhood-onset type 1 diabetes in Japan and Finland. Diabetes Care 26:2037-2042
2. Skrivarhaug T, Bangstad HJ, Stene LC, Sandvik L, Hanssen KF, Joner G (2006) Long-term mortality in a nationwide cohort of childhood-onset type 1 diabetic patients in Norway. Diabetologia 49:298-305
3. Stadler M, Auinger M, Anderwald C, Kastenbauer T, Kramar R, Feinbock C, Irsigler K, Kronenberg F, Prager R (2006) Long-term mortality and incidence of renal dialysis and transplantation in type 1 diabetes mellitus. J Clin Endocrinol Metab 91:3814-3820
4. Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, Marks JS (2003) Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289:76-79
5. Wild S, Roglic G, Green A, Sicree R, King H (2004) Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047-1053
6. The DIAMOND Project Group (2006) Incidence and trends of childhood Type 1 diabetes worldwide 1990-1999. Diabet Med 23:857-866
7. Mathiesen ER, Hommel E, Giese J, Parving HH (1991) Efficacy of captopril in postponing nephropathy in normotensive insulin dependent diabetic patients with microalbuminuria. BMJ 303:81-87
8. Viberti G (1994) Prognostic significance of microalbuminuria. Am J Hypertens 7:69S-72S
9. Laverman GD, Navis G, Henning RH, de Jong PE, de Zeeuw D (2002) Dual renin-angiotensin system blockade at optimal doses for proteinuria. Kidney Int 62:1020-1025
10. Jacobsen P, Andersen S, Rossing K, Jensen BR, Parving HH (2003) Dual blockade of the renin-angiotensin system versus maximal recommended dose of ACE inhibition in diabetic nephropathy. Kidney Int 63:1874-1880
11. Perrin NE, Torbjornsdotter TB, Jaremko GA, Berg UB (2006) The course of diabetic glomerulopathy in patients with type I diabetes: A 6-year follow-up with serial biopsies. Kidney Int 69:699-705
12. Berg UB, Torbjornsdotter TB, Jaremko G, Thalme B (1998) Kidney morphological changes in relation to long-term renal function and metabolic control in adolescents with IDDM. Diabetologia 41:1047-1056
13. Hoelzel W, Weykamp C, Jeppsson JO, Miedema K, Barr JR, Goodall I, Hoshino T, John WG, Kobold U, Little R, Mosca A, Mauri P, Paroni R, Susanto F, Takei I, Thienpont L, Umemoto M, Wiedmeyer HM (2004) IFCC reference system for measurement of hemoglobin A1c in human blood and the national standardization schemes in the United States, Japan, and Sweden: A method-comparison study. Clin Chem 50:166-174
14. The Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329:977-986
15. Perrin NE, Torbjornsdotter TB, Jaremko GA, Berg UB (2004) Follow-up of kidney biopsies in normoalbuminuric patients with type 1 diabetes. Pediatr Nephrol 19:1004-1013
16. Andersen S, Tarnow L, Rossing P, Hansen BV, Parving HH (2000) Renoprotective effects of angiotensin II receptor blockade in type 1 diabetic patients with diabetic nephropathy. Kidney Int 57:601-606
17. Mogensen CE, Neldam S, Tikkanen I, Oren S, Viskoper R, Watts RW, Cooper ME (2000) Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: The candesartan and lisinopril microalbuminuria (CALM) study. BMJ 321:1440-1444
18. Taal MW, Brenner BM (2000) Renoprotective benefits of RAS inhibition: from ACEI to angiotensin II antagonists. Kidney Int 57:1803-1817
19. The European Study for the Prevention of Renal Disease in Type 1 Diabetes (ESPRIT) (2001) Effect of 3 years of antihypertensive therapy on renal structure in type 1 diabetic patients with albuminuria. Diabetes 50:843-850
20. Rudberg S, Osterby R, Bangstad HJ, Dahlquist G, Persson B (1999) Effect of angiotensin converting enzyme inhibitor or beta blocker on glomerular structural changes in young microalbuminuric patients with Type I (insulin-dependent) diabetes mellitus. Diabetologia 42:589-595
21. Bangstad HJ, Osterby R, Dahl-Jorgensen K, Berg KJ, Hartmann A, Nyberg G, Frahm Bjorn S, Hanssen KF (1993) Early glomerulopathy is present in young, type 1 (insulin-dependent) diabetic patients with microalbuminuria. Diabetologia 36:523-529
22. Rudberg S, Osterby R, Dahlquist G, Nyberg G, Persson B (1997) Predictors of renal morphological changes in the early stage of microalbuminuria in adolescents with IDDM. Diabetes Care 20:265-271
23. Bangstad HJ, Osterby R, Rudberg S, Hartmann A, Brabrand K, Hanssen KF (2002) Kidney function and glomerulopathy over 8 years in young patients with Type I (insulin-dependent) diabetes mellitus and microalbuminuria. Diabetologia 45:253-261
24. Laffel LM, McGill JB, Gans DJ (1995) The beneficial effect of angiotensin-converting enzyme inhibition with captopril on diabetic nephropathy in normotensive IDDM patients with microalbuminuria. North American Microalbuminuria Study Group. Am J Med 99:497-504
25. Ahmad J, Shafique S, Abidi SM, Parwez I (2003) Effect of 5-year enalapril therapy on progression of microalbuminuria and glomerular structural changes in type 1 diabetic subjects. Diabetes Res Clin Pract 60:131-138
26. Drummond K, Levy-Marchal C, Laborde K, Kindermans C, Wright C, Dechaux M, Czernichow P (1989) Enalapril does not alter renal function in normotensive, normoalbuminuric, hyperfiltering type 1 (insulin-dependent) diabetic children. Diabetologia 32:255-260
27. Mathiesen ER, Borch-Johnsen K, Jensen DV, Deckert T (1989) Improved survival in patients with diabetic nephropathy. Diabetologia 32:884-886
28. Brenner BM, Cooper ME, de Zeeuw D, Keane WF, Mitch WE, Parving HH, Remuzzi G, Snapinn SM, Zhang Z, Shahinfar S (2001) Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 345:861-869
29. Tutuncu NB, Gurlek A, Gedik O (2001) Efficacy of ACE inhibitors and ATII receptor blockers in patients with microalbuminuria: A prospective study. Acta Diabetol 38:157-161
30. Strippoli GF, Bonifati C, Craig M, Navaneethan SD, Craig JC (2006) Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists for preventing the progression of diabetic kidney disease. Cochrane Database Syst Rev:CD006257
31. Parving HH, Hommel E, Jensen BR, Hansen HP (2001) Long-term beneficial effect of ACE inhibition on diabetic nephropathy in normotensive type 1 diabetic patients. Kidney Int 60:228-234
32. Walker JD, Close CF, Jones SL, Rafftery M, Keen H, Viberti GC, Osterby R (1992) Glomerular structure in type-1(insulin-dependent) diabetic patients with normo- and microalbuminuria. Kidney Int 41:741-748
33. Fioretto P, Steffes MW, Mauer M (1994) Glomerular structure in nonproteinuric IDDM patients with various levels of albuminuria. Diabetes 43:1358-1364
34. Bergstrom J, Alvestrand A, Bucht H, Gutierrez A (1986) Progression of chronic renal failure in man is retarded with more frequent clinical follow-ups and better blood pressure control. Clin Nephrol 25:1-6
35. Dobrilla G, Scarpignato C (1994) Placebo and placebo effect: Their impact on the evaluation of drug response in patients. Dig Dis 12:368-377
36. Musial F, Klosterhalfen S, Enck P (2007) Placebo responses in patients with gastrointestinal disorders. World J Gastroenterol 13:3425-3429