The role of immunohistochemistry in histopathological diagnostics of clinically "silent" incidentally detected adrenal masses

Experimental and Clinical Endocrinology and Diabetes

Volumn 116, Issue 4, 2008, Pages 246-251

  Babinska, A ^a   Sworczak, K ^a   Wisniewski, P ^a   Nalecz A ^a   Jaskiewicz, K ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Adrenal incidentalomas; Expression of p53; Immunohistochemistry; Ki67; p21; PCNA

Indexed keywords

KI 67 ANTIGEN; MONOCLONAL ANTIBODY; PROTEIN P21; PROTEIN P53;

ADRENAL CORTEX ADENOMA; ADRENAL CORTEX ADRENOCARCINOMA; ADRENAL INCIDENTALOMA; ARTICLE; CORRELATION ANALYSIS; DIFFERENTIAL DIAGNOSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; TUMOR DIAGNOSIS;

ADENOMA; ADRENAL GLAND NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; P21-ACTIVATED KINASES; PHEOCHROMOCYTOMA; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 42649093507     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-993164     Document Type: Article

References (33)

1. Allison RT, Best T. P53, PCNA and Ki-67 expression in oral squamous cell carcinomas: the vagaries of fixation and microwave enhancement of immunocytochemistry. J Oral Pathol Med 1998; 27 (9): 434-440
2. Aron DC. Adrenal incidentalomas and glucocorticoid autonomy. Clin Endocrinol (Oxf) 1998; 49 (2): 157-158
3. Bernini GP, Moretti A, Viacava P, Bonadio AG, Iacconi P, Miccoli P, Salvetti A. Apoptosis control and proliferation marker in human normal and neoplastic adrenocortical tissues. Br J Cancer 2002; 86 (10): 1561-1565
4. Bertherat J, Gimenez-Roqueplo AP. New insights in the genetics of adrenocortical tumors, pheochromocytomas and paragangliomas. Horm Metab Res 2005; 37 (6): 384-390
5. Bravo EL, Tagle R. Pheochromocytoma: state-of-the-art and future prospects. Endocr Rev 2003; 24 (4): 539-553
6. Dackiw AP, Lee JE, Gagel RF, Evans DB. Adrenal cortical carcinoma. World J Surg 2001; 25 (7): 914-926
7. Fu CG, Tominaga O, Nagawa H, Nita ME, Masaki T, Ishimaru G, Higuchi Y, Tsuruo T, Muto T. Role of p53 and p21/WAF1 detection in patient selection for preoperative radiotherapy in rectal cancer patients. Dis Colon Rectum 1998; 41 (1): 68-74
8. Grumbach MM, Biller BM, Braunstein GD, Campbell KK, Carney JA, Godtey PA, Harris EL, Lee JK, Oertel YC, Posner MC, Schlechte JA, Wieand HS. Management of the clinically inapparent adrenal mass ("incidentaloma") . Ann Intern Med 2003; 138 (5): 424-429
9. Hoss A, Urist MJ, Stojadinovic A, Mastorides S, Dudas ME, Leung DH, Kuo D, Brennan MF, Lewis JJ, Cordon-Cardo C. Validation of tissue microarrays for immunohistochemical profiling of cancer specimens using the example of human fibroblastic tumors. Am J Pathol 2001; 158: 1245-1251
10. Ignaszczak-Szczepaniak M, Sawicka J, Sowinski J, Horst-Sikorska W. Genetics in development of adrenal cortex neoplasia. Endokrynol Pol 2003; 54: 339-349
11. Ito Y, Obara T, Okamoto T, Kanbe M, Tanaka R, Ihara M, Okamoto J, Yamazaki K, Jibiki K. Efficacy of single - voided urine metanephrine and normetanephrine assay for diagnosis pheochromocytoma. World J Surg 1998; 22 (7): 684-688
12. Kasperlik-Zaluska AA, Migdalska BM, Makowska AM. Incidentally found adrenocortical carcinoma. A study of 21 patients. Eur J Cancer 1998; 34(11): 1721-1724
13. Kubiak R, Kopczynski J, Pasz-Walczak G, Jesionek-Kupnicka D, Kordek R. Usefulness of immunohistochemistry in differential diagnosis of epithelial renal and adrenal gland tumors. Wspolczesna Onkologia 2004; 8 (6): 308-312
14. Lack EE. Tumours of the adrenal gland. In: Diagnostic Histopatology of Tumors, 2nd ed Ch. Fletcher. Curchill Livingstone, 2000; 19: 1057-1080
15. Linde NG, Libertino JM. Adrenocortical carcinoma: diagnosis, evaluation and treatment. J Urol 2003; 169 (1): 5-11
16. Linos DA. Management approaches to adrenal incidentalomas (adenomas): a view from Athens, Greece, Italy. Endocr Metab Clin North Am 2000; 29: 107-109
17. Martins AC, Cologna AJ, Tucci Jr S, Suaid HJ, Falconi RA. Clinical features and immunoexpression of p53, MIB-1 and proliferating cell nuclear antigen in adrenal neoplasms. J Urol 2005; 173 (6): 2138-2142
18. Orlando C, Gelmini S. Telomerase in endocrine and endocrine - dependent tumors. J Steroid Biochem Mol Biol 2001; 78 (3): 201-214
19. Song SY, Park S, Kim SR, Suh YL. Oncocytic adrenocortical carcinomas: a pathological and immunohistochemical study of four cases in comparison with conventional adrenocortical carcinoma. Pathol Int 2004; 54 (8): 603-610
20. Stojadinovic A, Brennan MF, Hoos A, Omeroglu A, Leung DH, Dudas ME, Nissan A, Cordo-Cardo C, Ghossein RA. Adrenocortical adenoma and carcinoma: histopathological and molecular comparative analysis. Mod Pathol 2003; 16 (8): 742-751
21. Stojadinovic A, Ghossein RA, Hoos A, Nissan A, Marshall D, Dudas M, Cordon-Cardo C, Jaques DP, Brennan MF. Adrenocortical carcinoma: clinical, morphologic and molecular characterization. J Clin Oncol 2002; 20(4): 941-950
22. Stratakis CA. Genetics of adrenocortical tumors: gatekeepers, landscapes and conductors in symphony. Trends Endocrinol Metab 2003; 14 (9): 404-410
23. Sworczak K, Babinska A, Stanek A, Lewczuk A, Siekierska-Hellmann M, Blaut K, Drobinska A, Basinski A, Lachinski AJ, Czaplinska-Kalas H, Gruca Z. Clinical and histopatological evaluation of adrenal incidentaloma. Neoplasma 2001; 48 (3): 221-226
24. Sworczak K, Bielawski KP, Falkiewicz B, Babinska A, Zaczek A, Lisowska U. Dysregulation of erbB family genes and ErbB (HER) receptors in pheochromocytoma. Współczesna Onkologia 2004; 8 (4): 213-218
25. Sworczak K, Zaczek A, Babinska A, Lisowska U, Bielawski KP, Falkiewicz B. Gene copy numbers of erbB oncogenes in human pheochromocytoma. Oncology Rep 2002; 9: 1373-1378
26. Takehara K, Sakai H, Shono T, Irie J, Kanetake H. Proliferative activity and genetic changes in adrenal cortical tumors examined by flow cytometry, fluorescence In situ hybridization and immunohistochemistry. Int J Urol 2005; 12 (2): 121-127
27. Terzolo M, Boccuzzi A, Bovio S, Cappia S, Giuli P De, Ali A, Paccotti P, Porpiglia F, Fontana D, Angeli A. Immunohistochemical assessment of Ki-67 in the differential diagnosis of adrenocortical tumors. Urology 2001; 57 (1): 176-182
28. Torlontano M, Chiodini I, Pileri M, Guglielmi G, Cammisa M, Modoni S, Carnevale V, Trischitta V, Scillitani A. Altered bone mass and turnover in female patients with adrenal incidentaloma: the effect of subclinical hypercortisolism. J Clin Endocrinol Metab 1999; 84 (7): 2381-2385
29. Tupikowski W, Bednarek-Tupikowska G, Florczak A. Adrenocortical carcinoma and its treatment. Postepy Hig Med Dosw 2004; 58: 27-36
30. Tutuncu NB, Gedik O. Adrenal incidentaloma: report of 33 cases. J Surg Oncol 1999; 70 (4): 247-250
31. Slooten H Van, Schaberg A, Smeenk D, Moolenaar AJ. Morphologic characteristics of benign and malignant adrenocortical tumors. Cancer 1985; 55 (4): 766-773
32. Vargas MP, Vargas HI, Kleiner DE, Merino MJ. Adrenocortical neoplasms: role of prognostic markers MIB-1, P53, and RB. Am J Surg Pathol 1997; 21 (5): 556-562
33. Weiss LM, Medeiros LJ, Vickery AL. Pathologic features of prognostic significance in adrenocortical carcinoma. Am J Surg Pathol 1989; 13: 202-206