Should liver function tests be included in definitions of metabolic syndrome? Evidence from the association between liver function tests, components of metabolic syndrome and prevalent cardiovascular disease

Diabetic Medicine

Volumn 25, Issue 5, 2008, Pages 523-529

  Devers, M C ^a   Campbell, S ^b   Shaw, J ^d   Zimmet, P ^d   Simmons, D ^c,e,f  

^a GLASGOW ROYAL INFIRMARY   (United Kingdom)

^b HAIRMYRES HOSPITAL   (United Kingdom)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^e CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^f ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

CVD; Diabetes; Non alcoholic steatohepatitis; Visceral fat

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; FEMALE; HEALTH SURVEY; HUMAN; LIVER DISEASE; LIVER FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; ROC CURVE;

ADULT; AGED; CARDIOVASCULAR DISEASES; CROSS-SECTIONAL STUDIES; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; LIVER FUNCTION TESTS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; RANDOM ALLOCATION; RISK FACTORS; VICTORIA; WAIST-HIP RATIO;

EID: 42549170971     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2008.02408.x     Document Type: Article

References (30)

1. Kahn R, Buse J, Ferrannini E, Stern M. The metabolic syndrome: time for a critical appraisal. Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 2005 48 : 1684 1699.
2. International Diabetes Federation. The IDF consensus worldwide definition of the metabolic syndrome. Available at: http://www.idf.org/
3. Gale E. The myth of the metabolic syndrome. Diabetologia 2005 48 : 1679 1683.
4. Expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III). Executive summary of the third report of the National Cholesterol Education Program (NCEP). JAMA 2001 285 : 2486 2497.
5. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005 365 : 1415 1428.
6. Zimmet PZ, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001 414 : 782 787.
7. Farrell GC. Non-alcoholic steatohepatitis: what is it, and why is it important in the Asian-Pacific region? J Gastroenterol Hepatol 2003 18 : 124 138.
8. Raz I, Eldor R, Cernea S, Shafrir E. Diabetes: insulin resistance and derangements in lipid metabolism. Cure through intervention in fat transport and storage. Diabetes Metab Res Rev 2005 21 : 3 14.
9. Unger RH. Longevity, lipotoxicity and leptin: the adipocyte defence against feasting and famine. Biochimie 2005 87 : 57 64.
10. Simmons DA, Eaton A, Shaw J, Zimmet PZ. Prevalence of diabetes in rural Victoria. Diabetes Res Clin Pract 2005 70 : 287 290.
11. Simmons D, McKenzie Shaw J, McKenzie A, Eaton S, Cameron AJ, Zimmet PZ. Is grand multiparity associated with an increased risk of dysglycaemia? Diabetologia 2006 49 : 1522 1527.
12. Bellentani S, Saccoccio G, Costa G, Tiribelli C, Manenti F, Sodde M et al. Drinking habits as cofactors of risk for alcohol induced liver damage. Gut 1997 41 : 845 850.
13. Youden WJ. An index for rating diagnostic tests. Cancer 1950 3 : 32 35.
14. Scuteri A, Najjar SS, Morrell CH, Lakatta EG. The metabolic syndrome in older individuals: prevalence and prediction of cardiovascular events: the Cardiovascular Health Study. Diabetes Care 2005 28 : 882 887.
15. Sundstrom J, Riserus U, Byberg L, Zethelius B, Lithell H, Lind L. Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study. BMJ 2006 332 : 878 882.
16. Sundstrom J, Vallhagen E, Riserus U, Byberg L, Zethelius B, Berne C et al. Risk associated with the metabolic syndrome versus the sum of its individual components. Diabetes Care 2006 29 : 1673 1674.
17. Ruttmann E, Brant LJ, Concin H, Diem G, Rapp K, Ulmer H. Gamma-glutamyltransferase as a risk factor for cardiovascular disease mortality: an epidemiological investigation in a cohort of 163 944 Austrian adults. Circulation 2005 112 : 2130 2137.
18. Pladevall M, Singal B, Williams LK, Brotons C, Guyer H, Sadurni J et al. A single factor underlies the metabolic syndrome: a confirmatory factor analysis. Diabetes Care 2006 29 : 113 122.
19. Yudkin JS, Eringa E, Stehouwer CD. 'Vasocrine' signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease. Lancet 2005 365 : 1817 1820.
20. Hanley AJ, Williams K, Festa A, Wagenknecht LE, D'Agostino RB Jr., Haffner SM. Liver markers and development of the metabolic syndrome. The Insulin Resistance Atherosclerosis Study. Diabetes 2005 54 : 3140 3147.
21. Sattar N, Scherbakova O, Ford I, O'Reilly DS, Stanley A, Forrest E et al. Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the West of Scotland Coronary Prevention Study. Diabetes 2004 53 : 2855 2860.
22. Nannipieri M, Gonzales C, Baldi S, Posadas R, Williams K, Haffner SM et al. Liver enzymes, the metabolic syndrome, and incident diabetes. The Mexico City diabetes study. Diabetes Care 2005 28 : 1757 1762.
23. Mirmiran P, Esmaillzadeh A, Azizi F. Detection of cardiovascular risk factors by anthropometric measures in Tehran adults: receiver operating characteristic (ROC) curve analysis. Eur J Clin Nutr 2004 58 : 1110 1118.
24. Mukamal KJ, Conigrave KM, Mittleman MA, Camargo CA, Stampfer MJ, Willett WC et al. Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men. N Engl J Med 2003 348 : 109 118.
25. Cohen DE, Anania FA, Chalasani N. An assessment of statin safety by hepatologists. Am J Cardiol 2006 97 (Suppl 77C 81C.
26. Gomex-Dominguez E, Gispert JP, Moreno-Monteagudo JA, Garcia-Buey L, Moreno-Otero R. A pilot study of atorvastatin treatment in dyslipidemic, non-alcoholic fatty liver patients. Aliment Pharmacol Ther 2006 23 : 1643 1647.
27. Campbell S, George DK, Robb SD, Spooner R, McDonagh TA, Dargie HJ et al. The prevalence of haemochromatosis gene mutations in the West of Scotland and their relationship to ischaemic heart disease. Heart 2003 89 : 1023 1026.
28. Olynyk JK, Cullen DJ, Aquilia S, Rossi E, Summerville L, Powell LW. A population based study of the clinical expression of the hemochromatosis gene. N Engl J Med 1999 341 : 718 724.
29. Amin J, Gidding HF, Gilbert GL, Backhouse J, Kaldor JM, Dore GJ et al. Hepatitis C prevalence - a nationwide serosurvey. Commun Dis Intell 2004 28 : 517 521.
30. Momiyama Y, Ohmori R, Kato R, Taniguchi H, Nakamura H, Ohsuzu F. Lack of any association between persistent hepatitis B or C virus infection and coronary artery disease. Atherosclerosis 2005 181 : 211 213.