BMP inhibition enhances axonal growth and functional recovery after spinal cord injury

Journal of Neurochemistry

Volumn 105, Issue 4, 2008, Pages 1471-1479

  Matsuura, Iichiro ^a   Taniguchi, Junko ^a   Hata, Katsuhiko ^a,b   Saeki, Naokatsu ^a   Yamashita, Toshihide ^a,b,c  

^a CHIBA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Axon; Bone morphogenetic proteins; Neuron; Regeneration; Spinal cord

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; NOGGIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; LOCOMOTION; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCAR FORMATION; SPINAL CORD INJURY;

ANIMALS; AXONS; BONE MORPHOGENETIC PROTEINS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL ENLARGEMENT; FEMALE; HUMANS; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SPINAL CORD INJURIES;

EID: 42549129406     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05251.x     Document Type: Article

References (14)

1. Basso D. M., Beattie M. S. Bresnahan J. C. (1995) A sensitive and reliable locomotor rating scale for open field testing in rats. J. Neurotrauma 12, 1 21.
2. Bradbury E.J., Moon L.D., Popat R.J. et al. (2002) Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature 416, 636 640.
3. Cao Q., Xu X. M., Devries W. H. et al. (2005) Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin- expressing glial-restricted precursor cells. J. Neurosci. 25, 6947 6957.
4. Enzmann G. U., Benton R. L., Woock J. P. et al. (2005) Consequences of noggin expression by neural stem, glial, and neuronal precursor cells engrafted into the injured spinal cord. Exp. Neurol. 195, 293 304.
5. Harel N. Y. Strittmatter S. M. (2006) Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat. Rev. Neurosci. 7, 603 616.
6. Kubo T., Hata K., Yamaguchi A. Yamashita T. (2007) Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration. Curr. Pharm. Des. 13, 2493 2499.
7. Matsuura I., Endo M., Hata K., Kubo T., Yamaguchi A., Saeki N. Yamashita T. (2007) BMP inhibits neurite growth by a mechanism dependent on LIM-kinase. Biochem. Biophys. Res. Commun. 360, 868 873.
8. McKeon R. J., Schreiber R. C., Rudge J. S. et al. (1991) Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes. J. Neurosci. 11, 3398 3411.
9. Miyazono K., Maeda S. Imamura T. (2005) BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev. 16, 251 263.
10. Setoguchi T., Yone K., Matsuoka E. et al. (2001) Traumatic injury-induced BMP7 expression in the adult rat spinal cord. Brain Res. 921, 219 225.
11. Setoguchi T., Nakashima K., Takizawa T. et al. (2004) Treatment of spinal cord injury by transplantation of fetal neural precursor cells engineered to express BMP inhibitor. Exp. Neurol. 189, 33 44.
12. Yamashita T., Mueller B.K. Hata K. (2007) Neogenin and RGM signaling in the central nervous system. Curr. Opin. Neurobiol. 17, 29 34.
13. Yanagita M. (2005) BMP antagonists: their roles in development and involvement in pathophysiology. Cytokine Growth Factor Rev. 16, 309 317.
14. Yiu G. He Z. (2006) Glial inhibition of CNS axon regeneration. Nat. Rev. Neurosci. 7, 617 627.