Irinotecan chemotherapy during valproic acid treatment: Pharmacokinetic interaction and hepatotoxicity

Cancer Biology and Therapy

Volumn 6, Issue 9, 2007, Pages 1364-1370

  De Jong, Floris A ^a   Van Der Bol, Jessica M ^a   Mathijssen, Ron H J ^a   Loos, Walter J ^a   Mathôt, Ron A A ^a   Kitzen, Jos J E M ^a   Van Den Bent, Martin J ^a   Verweij, Jaap ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Drug drug interaction; Hepatotoxicity; Irinotecan; Pharmacokinetics; Plasma protein binding displacement; UGT1A1; Valproic acid

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN GLUCURONIDE; AMINOTRANSFERASE; ANTICONVULSIVE AGENT; DEXAMETHASONE; GAMMA GLUTAMYLTRANSFERASE; GLUCURONOSYLTRANSFERASE; GRANISETRON; IRINOTECAN; VALPROIC ACID;

ADULT; ALOPECIA; AMINOTRANSFERASE BLOOD LEVEL; ANEMIA; AREA UNDER THE CURVE; ARTICLE; CANCER PATIENT; CASE REPORT; DIARRHEA; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG GLUCURONIDATION; DRUG PROTEIN BINDING; FEMALE; GALLBLADDER CARCINOMA; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HUMAN; LIVER METASTASIS; LIVER TOXICITY; NAUSEA; NEUTROPENIA; PHARMACODYNAMICS; SEIZURE; SENSORY NEUROPATHY; SINGLE DRUG DOSE; VOMITING;

EID: 42549109974     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.6.9.4567     Document Type: Article

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