Competitive ELISA-based screening of plant derivatives for the inhibition of VEGF family members interaction with vascular endothelial growth factor receptor 1

Planta Medica

Volumn 74, Issue 4, 2008, Pages 401-406

  Ponticelli, Salvatore ^a   Braca, Alessandra ^b   De Tommasi, Nunziatina ^c   De Falco, Sandro ^a  

^a INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c UNIVERSITY OF SALERNO   (Italy)

Author keywords

Angiogenesis; Chrysobalanaceae; Combretaceae; Flavonoids; Parinari campestris; Pteleopsis suberosa; Terpenes; VEGF PlGF and Flt 1

Indexed keywords

BUTANOL; CHLOROFORM; PARINARI CAMPESTRIS EXTRACT; PLACENTAL GROWTH FACTOR; PLANT EXTRACT; PTELEOPSIS SUBEROSA EXTRACT; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1;

ARTICLE; BIOASSAY; DOSE RESPONSE; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FRACTIONATION; PLANT LEAF; PROTEIN PROTEIN INTERACTION;

ENZYME-LINKED IMMUNOSORBENT ASSAY; MOLECULAR STRUCTURE; PLANT EXTRACTS; PLANTS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

CHRYSOBALANACEAE; COMBRETACEAE; PARINARI; PTELEOPSIS SUBEROSA;

EID: 42549109406     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1034346     Document Type: Article

References (24)

1. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. Vascular-specific growth factors and blood vessel formation. Nature 2000; 407: 242-8
2. Shibuya M. Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis. J Biochem Mol Biol 2006; 39: 469-8
3. Carmeliet P, Moons L, Luttun A, Vincenti V, Compernolle V, De Mol M et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med 2001; 7: 575-3
4. Bellomo D, Headrick JP, Silins GU, Paterson CA, Thomas PS, Gartside M et al. Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia. Circ Res 2000; 86: E29-35
5. Carmeliet P. Angiogenesis in health and disease. Nat Med 2003; 9: 653-60
6. Luttun A, Tjwa M, Carmeliet P. Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders. Ann N Y Acad Sci 2002; 979: 80-93
7. Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005; 438: 820-7
8. Fischer C, Jonckx B, Mazzone M, Zacchigna S, Loges S, Pattarini L et al. Anti-PIGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell 2007; 131: 63-75
9. Lyden D, Hattori K, Dias S, Costa C, Blaikie P, Butros L et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med 2001; 7: 1194-201
10. Fiore G, Nencini C, Cavallo F, Capasso A, Bader A, Giorgi G et al. In vitro antiproliferative effect of six Salvia species on human tumor cell lines. Phytotherapy Res 2006; 20: 01-3
11. De Leo M, Braca A, Sanogo R, Cardile V, De Tommasi N, Russo A. Antiproliferative activity of Pteleopsis suberosa leaf extract and its flavonoid components in human prostate carcinoma cells. Planta Med 2006; 72: 604-10
12. Siciliano T, Bader A, De Tommasi N, Morelli I, Braca A. Sulfated pregnane glycosides from Periploca graeca. J Nat Prod 2005; 68: 1164-8
13. Braca A, Abdel-Razik AF, Mendez J, Morelli I. A new kaurane diterpene dimer from Parinari campestris. Fitoterapia 2005; 76: 614-9
14. Otsuka H, Hirata E, Shinzato T, Takeda Y. Stereochemistry of mega-stigmane glucosides from Glochidion zeylanicum and Alangium premnifolium. Phytochemistry 2003; 62: 763-8
15. Xu HX, Kadota S, Wang H, Kurokawa M, Shiraki K, Matsumoto T et al. A new hydrolyzable tannin from Geum japonicum and its antiviral activity. Heterocycles 1994; 38: 167-75
16. Agrawal PK. Carbon-13 NMR of flavonoids. Amsterdam: Elsevier; 1989
17. Braca A, Armenise A, Morelli I, Mendez J, Mi Q, Chai H-B et al. Structure of kaurane-type diterpenes from Parinari sprucei and their potential anticancer activitiy. Planta Med 2004; 70: 540-50
18. Ballesta-Acosta MC, Pascual-Villalobos MJ, Rodriguez B. A new 24-noroleanane triterpenoid from Salvia carduacea. J Nat Prod 2002; 65: 1513-5
19. De Felice A, Bader A, Leone A, Sosa S, Della Loggia R, Tubaro A et al. New polyhydroxylated triterpenes and anti-inflammatory activity of Salvia hierosolymitana. Planta Med 2006; 72: 643-9
20. 2, and G, from Sedum sarmentosum (Crassulaceae). Chem Pharm Bull 2007; 55: 435-41
21. Mayer R. Three lupane derivates from Leptospermum scoparium. Arch Pharm 1996; 329: 447-50
22. McInnes AG, Walter JA, Wright JLC. Carbon-13 NMR spectra of Δ 24(28)-phytosterols. Org Magn Reson 1980; 13: 302-3
23. Bae DG, Kim TD, Li G, Yoon WH, Chae CB. Anti-flt1 peptide, a vascular endothelial growth factor receptor 1-specific hexapeptide, inhibits tumor growth and metastasis. Clin Cancer Res 2005; 11: 651-61.
24. Errico M, Riccioni T, Iyer S, Pisano C, Acharya KR, Persico MG et al. Identification of placenta growth factor determinants for binding and activation of Flt-1 receptor. J Biol Chem 2004; 279: 43929-39