Target metabolic profiling analysis of free amino acids in plasma as EOC/TBDMS derivatives by GC-SIM-MS

Biomedical Chromatography

Volumn 22, Issue 4, 2008, Pages 339-342

  Paik, Man Jeong ^a   Moon, Seung Min ^a,b   Kim, Kyoung Rae ^c   Choi, Sangdun ^b   Ahn, Young Hwan ^a,b   Lee, Gwang ^a,b  

^a Ajou University   (South Korea)

^b Ajou University School of Medicine   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

Ethoxycarbonyl tert butyldimethylsilyl derivatives; Free amino acids; Gas chromatography mass spectrometry in selected ion monitoring mode; Plasma; Target metabolic profiling analysis

Indexed keywords

FATTY ACIDS; GAS CHROMATOGRAPHY; IONS; MASS SPECTROMETRY; METABOLISM;

AMINO-ACIDS; ETHOXYCARBONYL/TERT-BUTYLDIMETHYLSILYL DERIVATIVE; FRAGMENT IONS; FREE AMINO ACIDS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY IN SELECTED ION MONITORING MODE; METABOLIC PROFILING; SELECTIVE DETECTION; SENSITIVE DETECTION; TARGET METABOLIC PROFILING ANALYSE; TERT-BUTYLDIMETHYLSILYL DERIVATIVES;

AMINO ACIDS;

ALANINE; AMINO ACID; ASPARTIC ACID; BENZOIC ACID; CARBONYL DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; FATTY ACID DERIVATIVE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HYDROXYPROLINE; ISOLEUCINE; LEUCINE; LYSINE; ORNITHINE; PHENYLALANINE; PIPECOLIC ACID; PROLINE; SERINE; THREONINE; TRYPTOPHAN; TYROSINE; VALINE;

ACCURACY; AMINO ACID ANALYSIS; ANALYTIC METHOD; ANALYTICAL ERROR; ARTICLE; CONTROLLED STUDY; FEMALE; GAS CHROMATOGRAPHY; HUMAN; ION MONITORING; MALE; MASS SPECTROMETRY; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SENSITIVITY ANALYSIS;

EID: 42549084753     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.939     Document Type: Article

References (5)

1. Chuang CK, Lin SP, Chen HH, Chen YC, Wang TJ, Shieh WH and Wu CJ. Plasma free amino acids and their metabolites in Taiwanese patients on hemodialysis and continuous ambulatory peritoneal dialysis. Clinica Chimica Acta 2006; 364: 209.
2. Paik MJ and Kim KR. Sequential ethoxycarbonylation, methoximation and tert-butyldimethylsilylation for simultaneous determination of amino acids and carboxylic acids by dual-column gas chromatography. Journal of Chromatography A 2004; 1034: 13.
3. Paik MJ, Lee HJ and Kim KR. Simultaneous retention index analysis of urinary amino acids and carboxylic acids for graphic recognition of abnormal state. Journal of Chromatography B 2005; 821: 94.
4. Rashed MS, Al-Ahaidib LY, Aboul-Enein HY, Al-Amoudi M and Jacob M. Determination of L-pipecolic acid in plasma using chiral liquid chromatography-electrospray tandem mass spectrometry. Clinical Chemistry 2001; 47: 2124.
5. Slocum RH and Cummings JG. Amino acids analysis of physiological samples. In: Hommes FA (ed). Techniques in Diagnostic Human Biochemical Genetics - a Laboratory Manual. Wiley-Liss: New York, 1991; 87.