Haptoglobin polymorphism: A novel genetic risk factor for celiac disease development and its clinical manifestations

Clinical Chemistry

Volumn 54, Issue 4, 2008, Pages 697-704

  Papp, Maria ^a   Foldi, Ildiko ^a   Nemes, Eva ^a   Udvardy, Miklos ^a   Harsfalvi, Jolan ^a   Altorjay, Istvan ^a   Mate, Istvan ^a   Dinya, Tamas ^a   Varvolgyi, Csaba ^a   Barta, Zsolt ^b   Veres, Gabor ^c   Lakatos, Peter Laszlo ^c   Tumpek, Judit ^a   Toth, Laszlo ^a   Szathmari, Erzsebet ^d   Kapitany, Aniko ^a   Gyetvai, Agnes ^a   Korponay Szabo, Ilma R ^a,e  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c SEMMELWEIS UNIVERSITY   (Hungary)

^d Kenezy Korhaz Rendelointezet   (Hungary)

^e HEIM PÁL CHILDREN S HOSPITAL   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

HAPTOGLOBIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CELIAC DISEASE; CHILD; CLINICAL FEATURE; CONTROLLED STUDY; DERMATITIS HERPETIFORMIS; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; GASTROINTESTINAL SYMPTOM; GEL ELECTROPHORESIS; GENETIC RISK; HUMAN; IRON DEFICIENCY ANEMIA; MAJOR CLINICAL STUDY; MALE; RISK FACTOR; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; INFANT; MIDDLE AGED; PATHOPHYSIOLOGY; PHENOTYPE; PRESCHOOL CHILD;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CELIAC DISEASE; CHILD; CHILD, PRESCHOOL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPTOGLOBINS; HUMANS; INFANT; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 42449163854     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2007.098780     Document Type: Article

References (40)

1. van Heel DA, West J. Recent advances in coeliac disease. Gut 2006;55:1037-46.
2. Dewar DH, Ciclitira PJ. Clinical features and diagnosis of celiac disease. Gastroenterology 2005;128:S19-24.
3. Latiano A, Mora B, Bonamico M, Megiorni F, Mazzilli MC, Cucchiara S, et al. Analysis of candidate genes on chromosomes 5q and 19p in celiac disease. J Pediatr Gastroenterol Nutr 2007;45:180-6.
4. Rewers M. Epidemiology of celiac disease: what are the prevalence, incidence, and progression of celiac disease? Gastroenterology 2005;128:S47-51.
5. Yang F, Friedrichs WE, Navarijo-Ashbaugh AL, deGraffenried LA, Bowman BH, Coalson JJ. Cell type-specific and inflammatory-induced expression of haptoglobin gene in lung. Lab Invest 1995;73:433-40.
6. Theilgaard-Monch K, Jacobsen LC, Nielsen MJ, Rasmussen T, Udby L, Gharib M, et al. Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation. Blood 2006;108:353-61.
7. Yerbury JJ, Rybchyn MS, Easterbrook-Smith SB, Henriques C, Wilson MR. The acute phase protein haptoglobin is a mammalian extracellular chaperone with an action similar to clusterin. Biochemistry 2005;44:10914-25.
8. Kristiansen M, Graversen JH, Jacobsen C, Sonne O, Hoffman HJ, Law SK, Moestrup SK. Identification of the haemoglobin scavenger receptor. Nature (Lond) 2001;409:198-201.
9. Langlois MR, Delanghe JR. Biological and clinical significance of haptoglobin polymorphism in humans. Clin Chem 1996;42:1589-600.
10. Arredouani M, Matthijs P, Van Hoeyveld E, Kasran A, Baumann H, Ceuppens JL, Stevens E. Hemoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release. Immunology 2003;108:144-51.
11. Bowman BH, Kurosky A. Haptoglobin: the evolutionary product of duplication, unequal crossing over, and point mutation. Adv Hum Genet 1982;12:189-261.
12. Koch W, Latz W, Eichinger M, Roguin A, Levy AP, Schomig A, Kastrati A. Genotyping of the common haptoglobin Hp 1/2 polymorphism based on PCR. Clin Chem 2002;48:1377-82.
13. Carter K, Worwood M. Haptoglobin: a review of the major allele frequencies worldwide and their association with diseases. Int J Lab Hematol 2007;29:92-110.
14. Marks J, Roberts DF, Wyatt EH, Shuster S, Macdonald J, Watson AJ, et al. Some genetic aspects of coeliac disease and dermatitis herpetiformis. Gut 1971;12:857.
15. Marsh MN. Gluten, major histocompatibility complex, and the small intestine: a molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology 1992;102:330-54.
16. Hill ID, Dirks MH, Liptak GS, Colletti RB, Fasano A, Guandalini S, et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 2005;40:1-19.
17. Ladinser B, Rossipal E, Pittschieler K. Endomysium antibodies in coeliac disease: an improved method. Gut 1994;35:776-8.
18. Ambrus A, Banyai I, Weiss MS, Hilgenfeld R, Keresztessy Z, Muszbek L, Fesus L. Calcium binding of transglutaminases: a 43Ca NMR study combined with surface polarity analysis. J Biomol Struct Dyn 2001;19:59-74.
19. Sulkanen S, Halttunen T, Laurila K, Kolho KL, Korponay-Szabo IR, Sarnesto A, et al. Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease. Gastroenterology 1998;115:1322-8.
20. Kapitany A, Toth L, Tumpek J, Csipo I, Sipos E, Woolley N, et al. Diagnostic significance of HLA-DQ typing in patients with previous coeliac disease diagnosis based on histology alone. Aliment Pharmacol Ther 2006;24:1395-402.
21. Korponay-Szabo IR, Kovacs JB, Lorincz M, Goracz G, Szabados K, Balogh M. Prospective significance of antiendomysium antibody positivity in subsequently verified celiac disease. J Pediatr Gastroenterol Nutr 1997;25:56-63.
22. Collin P, Reunala T. Recognition and management of the cutaneous manifestations of celiac disease: a guide for dermatologists. Am J Clin Dermatol 2003;4:13-20.
23. Papp M, Lakatos PL, Palatka K, Foldi I, Udvardy M, Harsfalvi J, et al. Haptoglobin polymorphisms are associated with Crohn's disease, disease behaviour and extraintestinal manifestations in Hungarian patients. Dig Dis Sci 2007;52:1279-84.
24. Tauszik T, Szabo L. Haptoglobin polymorphism in Hungary. Gene Geogr 1992;6:153-7.
25. Dobryszycka W, Warwas M. Haptoglobin types in ovarian tumors. Neoplasma 1983;30:169-72.
26. Dahlqvist SR, Frohlander N. Haptoglobin groups and rheumatoid arthritis. Hum Hered 1985;35:207-11.
27. Rantapaa Dahlqvist S, Beckman G, Beckman L. Serum protein markers in systemic lupus erythematosus. Hum Hered 1988;38:44-7.
28. Branski D, Fasano A, Troncone R. Latest developments in the pathogenesis and treatment of celiac disease. J Pediatr 2006;149:295-300.
29. Amundsen SS, Vatn M, IBSEN study group, Wijmenga C, Sollid LM, Lie BA. Association analysis of MYO9B gene polymorphisms and inflammatory bowel disease in a Norwegian cohort. Tissue Antigens 2006;68:249-52.
30. Guetta J, Strauss M, Levy NS, Fahoum L, Levy AP. Haptoglobin genotype modulates the balance of Th1/Th2 cytokines produced by macrophages exposed to free hemoglobin. Atherosclerosis 2007;191:48-53.
31. Catassi C, Ratsch IM, Fabiani E, Rossini M, Bordicchia F, Candela F, Coeliac disease in the year 2000: exploring the iceberg. Lancet 1994;343:200-3.
32. Melamed-Frank M, Lache O, Enav BI, Szafranek T, Levy NS, Ricklis RM, et al. Structure-function analysis of the antioxidant properties of haptoglobin. Blood 2001;98:3693-8.
33. Levy AP. Genetics of diabetic cardiovascular disease: identification of a major susceptibility gene. Acta Diabetol 2003;40 (Suppl 2):S330-3.
34. Levy AP, Purushothaman KR, Levy NS, Purushothaman M, Strauss M, Asleh R, et al. Down-regulation of the hemoglobin scavenger receptor in individuals with diabetes and the Hp 2-2 genotype: implications for the response to intraplaque hemorrhage and plaque vulnerability. Circ Res 2007;101:106-10.
35. Moestrup SK, Moller HJ. CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response. Ann Med 2004;36:347-54.
36. Levy AP, Moreno PR. Intraplaque hemorrhage. Curr Mol Med 2006;6:479-88.
37. Salvati VM, Mazzarella G, Gianfrani C, Levings MK, Stefanile R, De Giulio B, et al. Recombinant human interleukin 10 suppresses gliadin dependent T cell activation in ex vivo cultured coeliac intestinal mucosa. Gut 2005;54:46-53.
38. Jue DM, Shim BS, Kang YS. Inhibition of prostaglandin synthase activity of sheep seminal vesicular gland by human serum haptoglobin. Mol Cell Biochem 1983;51:141-7.
39. Saeed SA, Ahmad N, Ahmed S. Dual inhibition of cyclooxygenase and lipoxygenase by human haptoglobin: its polymorphism and relation to hemoglobin binding. Biochem Biophys Res Commun 2007;353:915-20.
40. Langlois M, Delanghe J, Philippe J, Ouyang J, Bernard D, De Buyzere M, et al. Distribution of lymphocyte subsets in bone marrow and peripheral blood is associated with haptoglobin type: binding of haptoglobin to the B-cell lectin CD22. Eur J Clin Chem Clin Biochem 1997;35:199-205.