-
1
-
-
0025228518
-
Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo
-
Teicher BA, Herman TS, Holden SA, Wang YY, Pfeffer MR, Crawford JW, Frei IIIrd E. Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo. Science 1990; 247:1457-61.
-
(1990)
Science
, vol.247
, pp. 1457-1461
-
-
Teicher, B.A.1
Herman, T.S.2
Holden, S.A.3
Wang, Y.Y.4
Pfeffer, M.R.5
Crawford, J.W.6
Frei IIIrd, E.7
-
2
-
-
29344443251
-
The distribution of the anticancer drug Doxorubicin in relation to blood vessels in solid tumors
-
Primeau AJ, Rendon A, Hedley D, Lilge L, Tannock IF. The distribution of the anticancer drug Doxorubicin in relation to blood vessels in solid tumors. Clin Cancer Res 2005; 11:8782-8.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 8782-8788
-
-
Primeau, A.J.1
Rendon, A.2
Hedley, D.3
Lilge, L.4
Tannock, I.F.5
-
3
-
-
0034046024
-
The influence of cytotoxicity of macromolecules and of VEGF gene modulated vascular permeability on the enhanced permeability and retention effect in resistant solid tumors
-
Minko T, Kopecková P, Pozharov V, Jensen KD, Kopecek J. The influence of cytotoxicity of macromolecules and of VEGF gene modulated vascular permeability on the enhanced permeability and retention effect in resistant solid tumors. Pharm Res 2000; 17:505-14.
-
(2000)
Pharm Res
, vol.17
, pp. 505-514
-
-
Minko, T.1
Kopecková, P.2
Pozharov, V.3
Jensen, K.D.4
Kopecek, J.5
-
4
-
-
0035300423
-
Magnetic resonance pharmacoangiography to detect and predict chemotherapy delivery to solid tumors
-
Artemov D, Solaiyappan M, Bhujwalla ZM. Magnetic resonance pharmacoangiography to detect and predict chemotherapy delivery to solid tumors. Cancer Res 2001; 61:3039-44.
-
(2001)
Cancer Res
, vol.61
, pp. 3039-3044
-
-
Artemov, D.1
Solaiyappan, M.2
Bhujwalla, Z.M.3
-
5
-
-
33645775473
-
Non-invasive 1H/13C magnetic resonance spectroscopic imaging of the intratumoral distribution of temozolomide
-
Kato Y, Okollie B, Artemov D. Non-invasive 1H/13C magnetic resonance spectroscopic imaging of the intratumoral distribution of temozolomide. Magn Reson Med 2006; 55:755-61.
-
(2006)
Magn Reson Med
, vol.55
, pp. 755-761
-
-
Kato, Y.1
Okollie, B.2
Artemov, D.3
-
6
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005; 23:1011-27.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
7
-
-
0021633364
-
Macromolecule-drug conjugates in targeted cancer chemotherapy
-
Sezaki H, Hashida M. Macromolecule-drug conjugates in targeted cancer chemotherapy. Crit Rev Ther Drug Carrier Syst 1984; 1:1-38.
-
(1984)
Crit Rev Ther Drug Carrier Syst
, vol.1
, pp. 1-38
-
-
Sezaki, H.1
Hashida, M.2
-
8
-
-
0022858683
-
A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
-
Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986; 46:6387-92.
-
(1986)
Cancer Res
, vol.46
, pp. 6387-6392
-
-
Matsumura, Y.1
Maeda, H.2
-
9
-
-
0035052324
-
Vascular differences detected by MRI for metastatic versus nonmetastatic breast and prostate cancer xenografts
-
Bhujwalla ZM, Artemov D, Natarajan K, Ackerstaff E, Solaiyappan M. Vascular differences detected by MRI for metastatic versus nonmetastatic breast and prostate cancer xenografts. Neoplasia 2001; 3:143-53.
-
(2001)
Neoplasia
, vol.3
, pp. 143-153
-
-
Bhujwalla, Z.M.1
Artemov, D.2
Natarajan, K.3
Ackerstaff, E.4
Solaiyappan, M.5
-
12
-
-
0036536697
-
Biochemical changes associated with a multidrug-resisant phenotype of a human glioma cell line with temozolomide-acquired resisance
-
Ma J, Murphy M, O'Dwyer PJ, Berman E, Reed K, Gallo JM. Biochemical changes associated with a multidrug-resisant phenotype of a human glioma cell line with temozolomide-acquired resisance. Biochem Pharmacol 2002; 63:1219-28.
-
(2002)
Biochem Pharmacol
, vol.63
, pp. 1219-1228
-
-
Ma, J.1
Murphy, M.2
O'Dwyer, P.J.3
Berman, E.4
Reed, K.5
Gallo, J.M.6
-
14
-
-
0031036934
-
Expression of the mutated p53 tumor suppressor protein and its molecular and biochemical characterization in multidrug resistant MCF-7/Adr human breast cancer cells
-
Ogretmen B, Safa AR. Expression of the mutated p53 tumor suppressor protein and its molecular and biochemical characterization in multidrug resistant MCF-7/Adr human breast cancer cells. Oncogene 1997; 14:499-506.
-
(1997)
Oncogene
, vol.14
, pp. 499-506
-
-
Ogretmen, B.1
Safa, A.R.2
-
15
-
-
0033016056
-
14C-temozolomide following oral administration to patients with advanced cancer
-
14C-temozolomide following oral administration to patients with advanced cancer. Clin Cancer Res 1999; 5:309-17.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 309-317
-
-
Baker, S.D.1
Wirth, M.2
Statkevich, P.3
Reidenberg, P.4
Alton, K.5
Sartorius, S.E.6
Dugan, M.7
Cutler, D.8
Batra, V.9
Grochow, L.B.10
Donehower, R.C.11
Rowinsky, E.K.12
-
16
-
-
0345131719
-
High-performance liquid chromatographic determination and stability of 5-(3-methyltriazen-1-yl) -imidazo-4-carboximide, the biologically active product of the antitumor agent temozolomide, in human plasma
-
Kim HK, Lin CC, Parker D, Veals J, Lim J, Likhari P, Statkevich P, Marco A, Nomeir AA. High-performance liquid chromatographic determination and stability of 5-(3-methyltriazen-1-yl) -imidazo-4-carboximide, the biologically active product of the antitumor agent temozolomide, in human plasma. J Chromatogr B Biomed Sci Appl 1997; 703:225-33.
-
(1997)
J Chromatogr B Biomed Sci Appl
, vol.703
, pp. 225-233
-
-
Kim, H.K.1
Lin, C.C.2
Parker, D.3
Veals, J.4
Lim, J.5
Likhari, P.6
Statkevich, P.7
Marco, A.8
Nomeir, A.A.9
-
17
-
-
0035154078
-
High-performance liquid chromatographic analysis and stability of anti-tumor agent temozolomide in human plasma
-
Kim H, Likhari P, Parker D, Statkevich P, Marco A, Lin CC, Nomeir AA. High-performance liquid chromatographic analysis and stability of anti-tumor agent temozolomide in human plasma. J Pharm Biomed Anal 2001; 24:461-8.
-
(2001)
J Pharm Biomed Anal
, vol.24
, pp. 461-468
-
-
Kim, H.1
Likhari, P.2
Parker, D.3
Statkevich, P.4
Marco, A.5
Lin, C.C.6
Nomeir, A.A.7
-
18
-
-
0033120336
-
An LC/MS/MS method for the quantitation of MTIC (5-(3-N-methyltriazen-1-yl)- imidazole-4-carboxami de), a bioconversion product of temozolomide, in rat and dog plasma
-
Chowdhury SK, Laudicina D, Blumenkrantz N, Wirth M, Alton KB. An LC/MS/MS method for the quantitation of MTIC (5-(3-N-methyltriazen-1-yl)- imidazole-4-carboxami de), a bioconversion product of temozolomide, in rat and dog plasma. J Pharm Biomed Anal 1999; 19:659-68.
-
(1999)
J Pharm Biomed Anal
, vol.19
, pp. 659-668
-
-
Chowdhury, S.K.1
Laudicina, D.2
Blumenkrantz, N.3
Wirth, M.4
Alton, K.B.5
-
19
-
-
0032812622
-
Phase I and pharmacokinetic study of temozolomide on a daily-for-5-days schedule in patients with advanced solid malignancies
-
Hammond LA, Eckardt JR, Baker SD, Eckhardt SG, Dugan M, Forral K, Reidenberg P, Statkevich P, Weiss GR, Rinaldi DA, Von Hoff DD, Rowinsky EK. Phase I and pharmacokinetic study of temozolomide on a daily-for-5-days schedule in patients with advanced solid malignancies. J Clin Oncol 1999; 17:2604-13.
-
(1999)
J Clin Oncol
, vol.17
, pp. 2604-2613
-
-
Hammond, L.A.1
Eckardt, J.R.2
Baker, S.D.3
Eckhardt, S.G.4
Dugan, M.5
Forral, K.6
Reidenberg, P.7
Statkevich, P.8
Weiss, G.R.9
Rinaldi, D.A.10
Von Hoff, D.D.11
Rowinsky, E.K.12
-
20
-
-
0028133013
-
NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA
-
Denny BJ, Wheelhouse RT, Stevens MF, Tsang LL, Slack JA. NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA. Biochemistry 1994; 33:9045-51.
-
(1994)
Biochemistry
, vol.33
, pp. 9045-9051
-
-
Denny, B.J.1
Wheelhouse, R.T.2
Stevens, M.F.3
Tsang, L.L.4
Slack, J.A.5
-
22
-
-
0032188739
-
Phase I trial of temozolomide using an extended continuous oral schedule
-
Brock CS, Newlands ES, Wedge SR, Bower M, Evans H, Colquhoun I, Roddie M, Glaser M, Brampton MH, Rustin GJ. Phase I trial of temozolomide using an extended continuous oral schedule. Cancer Res 1998; 58:4363-7.
-
(1998)
Cancer Res
, vol.58
, pp. 4363-4367
-
-
Brock, C.S.1
Newlands, E.S.2
Wedge, S.R.3
Bower, M.4
Evans, H.5
Colquhoun, I.6
Roddie, M.7
Glaser, M.8
Brampton, M.H.9
Rustin, G.J.10
-
23
-
-
0033968973
-
Four-hourly scheduling of temozolomide improves tumour growth delay but not therapeutic index in A375M melanoma xenografts
-
Middleton MR, Kelly J, Goodger S, Thatcher N, Margison GP. Four-hourly scheduling of temozolomide improves tumour growth delay but not therapeutic index in A375M melanoma xenografts. Cancer Chemother Pharmacol 2000; 45:15-20.
-
(2000)
Cancer Chemother Pharmacol
, vol.45
, pp. 15-20
-
-
Middleton, M.R.1
Kelly, J.2
Goodger, S.3
Thatcher, N.4
Margison, G.P.5
-
24
-
-
0032728210
-
Phase I dose-escalation and pharmacokinetic study of temozolomide (SCH 52365) for refractory or relapsing malignancies
-
Brada M, Judson I, Beale P, Moore S, Reidenberg P, Statkevich P, Dugan M, Batra V, Cutler D. Phase I dose-escalation and pharmacokinetic study of temozolomide (SCH 52365) for refractory or relapsing malignancies. Br J Cancer 1999; 81:1022-30.
-
(1999)
Br J Cancer
, vol.81
, pp. 1022-1030
-
-
Brada, M.1
Judson, I.2
Beale, P.3
Moore, S.4
Reidenberg, P.5
Statkevich, P.6
Dugan, M.7
Batra, V.8
Cutler, D.9
-
25
-
-
85036954547
-
-
Schering corporation. Product informaion: TEMODAR® (temozolomide) CAPSULES. United States, NJ: Kenilworth, 2003.
-
Schering corporation. Product informaion: TEMODAR® (temozolomide) CAPSULES. United States, NJ: Kenilworth, 2003.
-
-
-
-
28
-
-
0242522338
-
N-Succinyl-chitosan as a drug carrier: Water-insoluble and water-soluble conjugates
-
Kato Y, Onishi H, Machida Y. N-Succinyl-chitosan as a drug carrier: Water-insoluble and water-soluble conjugates. Biomaterials 2004; 25:907-15.
-
(2004)
Biomaterials
, vol.25
, pp. 907-915
-
-
Kato, Y.1
Onishi, H.2
Machida, Y.3
-
29
-
-
13944273372
-
Characterizing extravascular fluid transport of macromolecules in the tumor interstitium by magnetic resonance imaging
-
Pathak AP, Artemov D, Ward BD, Jackson DG, Neeman M, Bhujwalla ZM. Characterizing extravascular fluid transport of macromolecules in the tumor interstitium by magnetic resonance imaging. Cancer Res 2005; 65:1425-32.
-
(2005)
Cancer Res
, vol.65
, pp. 1425-1432
-
-
Pathak, A.P.1
Artemov, D.2
Ward, B.D.3
Jackson, D.G.4
Neeman, M.5
Bhujwalla, Z.M.6
-
30
-
-
33744910853
-
Lymph node metastasis in breast cancer xenografts is associated with increased regions of extravascular drain, lymphatic vessel area, and invasive phenotype
-
Pathak AP, Artemov D, Neeman M, Bhujwalla ZM. Lymph node metastasis in breast cancer xenografts is associated with increased regions of extravascular drain, lymphatic vessel area, and invasive phenotype. Cancer Res 2006; 66:5151-8.
-
(2006)
Cancer Res
, vol.66
, pp. 5151-5158
-
-
Pathak, A.P.1
Artemov, D.2
Neeman, M.3
Bhujwalla, Z.M.4
-
31
-
-
0024994008
-
Vascular and interstitial barriers to delivery of therapeutic agents in tumors
-
Jain RK. Vascular and interstitial barriers to delivery of therapeutic agents in tumors. Cancer Metastasis Rev 1990; 9:253-66.
-
(1990)
Cancer Metastasis Rev
, vol.9
, pp. 253-266
-
-
Jain, R.K.1
-
32
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
-
Jain RK. Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy. Science 2005; 307:58-62.
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
33
-
-
0028470454
-
Barriers to drug delivery in solid tumors
-
Jain RK. Barriers to drug delivery in solid tumors. Sci Am 1994; 271:58-65.
-
(1994)
Sci Am
, vol.271
, pp. 58-65
-
-
Jain, R.K.1
-
34
-
-
0033067279
-
Vascular endothelial growth factor expression, vascular volume, and, capillary permeability in human brain tumors
-
discussion 40-41
-
Machein MR, Kullmer J, Fiebich BL, Plate KH, Warnke PC. Vascular endothelial growth factor expression, vascular volume, and, capillary permeability in human brain tumors. Neurosurgery 1999; 44:732-40, (discussion 40-41).
-
(1999)
Neurosurgery
, vol.44
, pp. 732-740
-
-
Machein, M.R.1
Kullmer, J.2
Fiebich, B.L.3
Plate, K.H.4
Warnke, P.C.5
-
35
-
-
2542628099
-
Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
-
Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res 2004; 64:3731-6.
-
(2004)
Cancer Res
, vol.64
, pp. 3731-3736
-
-
Tong, R.T.1
Boucher, Y.2
Kozin, S.V.3
Winkler, F.4
Hicklin, D.J.5
Jain, R.K.6
-
36
-
-
0034093609
-
Role of specific apoptotic pathways in the restoration of paclitaxel-induced apoptosis by valspodar in doxorubicin-resistant MCF-7 breast cancer cells
-
Chadderton A, Villeneuve DJ, Gluck S, Kirwan-Rhude AF, Gannon BR, Blais DE, Parissenti AM. Role of specific apoptotic pathways in the restoration of paclitaxel-induced apoptosis by valspodar in doxorubicin-resistant MCF-7 breast cancer cells. Breast Cancer Res Treat 2000; 59:231-44.
-
(2000)
Breast Cancer Res Treat
, vol.59
, pp. 231-244
-
-
Chadderton, A.1
Villeneuve, D.J.2
Gluck, S.3
Kirwan-Rhude, A.F.4
Gannon, B.R.5
Blais, D.E.6
Parissenti, A.M.7
-
37
-
-
33749576589
-
Genetic alterations associated with acquired temozolomide resistance in SNB-19, a human glioma cell line
-
Auger N, Thillet J, Wanherdrick K, Idbaih A, Legrier ME, Dutrillaux B, Sanson M, Poupon MF. Genetic alterations associated with acquired temozolomide resistance in SNB-19, a human glioma cell line. Mol Cancer Ther 2006; 5:2182-92.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2182-2192
-
-
Auger, N.1
Thillet, J.2
Wanherdrick, K.3
Idbaih, A.4
Legrier, M.E.5
Dutrillaux, B.6
Sanson, M.7
Poupon, M.F.8
|