Neutron-stimulated emission computed tomography of a multi-element phantom

Physics in Medicine and Biology

Volumn 53, Issue 9, 2008, Pages 2313-2326

  Floyd Jr , Carey E ^a,b   Kapadia, Anuj J ^a,b   Bender, Janelle E ^b   Sharma, Amy C ^a,b   Xia, Jessie Q ^a,b   Harrawood, Brian P ^a   Tourassi, Georgia D ^a   Lo, Joseph Y ^a,b   Crowell, Alexander S ^c,d   Kiser, Mathew R ^c,d   Howell, Calvin R ^c,d  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Duke University   (United States)

^c DUKE UNIVERSITY   (United States)

^d TRIANGLE UNIVERSITIES NUCLEAR LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DATA ACQUISITION; IMAGE ANALYSIS; IMAGING SYSTEMS; MEDICAL IMAGING; NEUTRON EMISSION;

MULTI ELEMENT PHANTOMS; TOMOGRAPHIC RECONSTRUCTION;

COMPUTERIZED TOMOGRAPHY;

ALGORITHM; APPARATUS; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; GAMMA SPECTROMETRY; ILLUMINATION; IMAGE RECONSTRUCTION; NEUTRON; NEUTRON STIMULATED EMISSION COMPUTED TOMOGRAPHY; PHANTOM; PRIORITY JOURNAL; SAMPLING; SPECTROSCOPY;

ALGORITHMS; DIAGNOSTIC IMAGING; EQUIPMENT DESIGN; GAMMA RAYS; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMAGE PROCESSING, COMPUTER-ASSISTED; MODELS, STATISTICAL; NEOPLASMS; NEUTRONS; PHANTOMS, IMAGING; SCATTERING, RADIATION; SPECTROPHOTOMETRY; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 42449155985     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/53/9/008     Document Type: Article

References (28)

1. Bender J E, Kapadia A J, Sharma A C, Tourassi G D, Harrawood B P and Floyd C E 2007 Breast cancer detection using neutron stimulated emission computed tomography: prominent elements and dose requirements Med. Phys. 34 3866-71
2. Brittenham G and Badman D 2003 Noninvasive measurement of iron: report of an NIDDK workshop Blood 101 15-9
3. Cottingham W N and Greenwood D A 1986 An Introduction to Nuclear Physics (New York: Cambridge University Press)
4. Dobrowolski Z, Drewniak T, Kwiatek W and Jakubik P 2002 Trace elements distribution in renal cell carcinoma depending on stage of disease Eur. Urol. 42 475-80
5. Evans R 1955 The Atomic Nucleus (New York: Addison-Wesley)
6. Floyd C E Jr, Bender J E, Sharma A C, Kapadia A, Xia J, Harrawood B, Tourassi G D, Lo J Y, Crowell A and Howell C 2006 Introduction to neutron stimulated emission computed tomography Phys. Med. Biol. 51 3375-90
7. Floyd C E, Jaszczak R J and Coleman R E 1985 Inverse Monte Carlo: a unified reconstruction algorithm for SPECT IEEE Trans. Nucl. Sci. 32 779-85
8. Floyd C E et al 2004 Neutron stimulated emission computed tomography of stable isotopes SPIE Medical Imaging (San Diego, CA) pp 248-54
9. Geraki K and Farquharson M 2002 Concentrations of Fe, Cu and Zn in breast tissue: a synchrotron XRF study Phys. Med. Biol. 47 2327-39
10. Gregoriadis G C, Apostolidis N S, Romanos A N and Paradellis T P 1983 A comparative study of trace elements in normal and cancerous colorectal tissues Cancer 52 508-19
11. Kak A C and Slaney M 1999 Principles of Computerized Tomographic Imaging (New York: IEEE)
12. Kapadia A J 2007 Accuracy and patient dose in neutron stimulated emission computed tomography for diagnosis of liver iron overload: simulations in GEANT4 Biomedical Engineering (Durham, NC: Duke University)
13. Kapadia A J, Floyd C E, Bender J E, Howell C R, Crowell A S and Kiser M R 2005 Non-invasive quantification of iron 56-Fe in beef liver using neutron stimulated emission computed tomography IEEE Nuclear Science Symp. Conf. 2005 4 2232-4
14. Kapadia A J, Tourassi G D, Sharma A C, Crowell A S, Kiser M R and Howell C R 2007 Experimental detection of iron overload in liver through neutron stimulated emission spectroscopy Phys. Med. Biol. submitted
15. Kapadia A J, Sharma A C, Tourassi G D, Bender J E, Crowell A S, Kiser M R, Howell C R and Floyd C E 2006a Neutron spectroscopy of mouse using neutron stimulated emission computed tomography (NSECT) IEEE Nuclear Science Symp. Conf. Rec. 2006 6 3546-8
16. Kapadia A J, Sharma A C, Tourassi G D, Bender J E, Crowell A S, Kiser M R, Howell C R and Floyd C E 2006b Neutron stimulated emission computed tomography (NSECT) for early detection of breast cancer IEEE Nuclear Science Symp. Conf. Rec. 2006 6 3928-31
17. Kapadia A J, Sharma A C, Tourassi G D, Bender J E, Crowell A S, Kiser M R, Howell C R and Floyd C E 2006c Non-invasive estimation of potassium (39 K) in Bovine liver using neutron stimulated emission computed tomography (NSECT) IEEE Nuclear Science Symp. Conf. Rec. 2006 4 2076-8
18. Kapadia A J, Sharma A C, Bender J E, Tourassi G D, Howell C R, Crowell A S, Kiser M R, Harrawood B P and Floyd C E 2008 Neutron stimulated emission computed tomography for diagnosis of breast cancer IEEE Trans. Nucl. Sci. 55 501-9
19. Knoll G F 2000 Radiation Detection and Measurement (Hoboken, NJ: Wiley)
20. Lange K and Carson R 1984 EM reconstruction algorithms for emission and transmission tomography J. Comput. Assist. Tomogr. 8 306-16
21. National Nuclear Data Center B N L 2007 National Nuclear Database NuDat 2.3, url: http://www.nndc.bnl.gov/nudat2, Accessed 10 November 2005
22. Ng K H, Bradley D A and Looi L M 1997 Elevated trace element concentrations in malignant breast tissues Br. J. Radiol. 70 375-82
23. Ng K H, Bradley D A, Looi L M, Seman Mahmood C and Khalik Wood A 1993 Differentiation of elemental composition of normal and malignant breast tissue by instrumental neutron activation analysis Appl. Radiat. Isot. 44 511-6
24. NIST 1990 XCOM: Photon Cross Sections Database url: http://physics.nist. gov/PhysRefData/Xcom/Text/XCOM.html, Accessed 10 November 2005
25. Rizk S and Sky-Peck H 1984 Comparison between concentrations of trace elements in normal and neoplastic human breast tissue Cancer Res. 44 5390-4
26. Schwartz A and Fink R 1974 Trace elements in normal and malignant human breast tissue Surgery 76 325-9
27. Sharma A C, Harrawood B P, Bender J E, Tourassi G D and Kapadia A J 2007 Neutron stimulated emission computed tomography: a Monte Carlo simulation approach Phys. Med. Biol. 52 6117-31
28. Stedman J D and Spyrou N M 1995 Major and trace element concentration differences between right and left hemispheres of the 'normal' human brain Nutrition 11 542-5