Antipsychotic-induced weight gain in patients with schizophrenia

JAMA

Volumn 299, Issue 16, 2008, Pages 1899-

  Venkatasubramanian, Ganesan ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

METFORMIN; NEUROLEPTIC AGENT; SOMATOMEDIN C; ANTIDIABETIC AGENT;

CLINICAL TRIAL; COGNITION; DRUG MECHANISM; ENERGY BALANCE; EXERCISE; HUMAN; INSULIN RESISTANCE; LETTER; LIFESTYLE MODIFICATION; NONHUMAN; PRIORITY JOURNAL; SCHIZOPHRENIA; SIDE EFFECT; WEIGHT GAIN; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; METABOLISM; NOTE; OBESITY; PHYSIOLOGY; RISK REDUCTION;

ANTIPSYCHOTIC AGENTS; EXERCISE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; METFORMIN; OVERWEIGHT; RISK REDUCTION BEHAVIOR; SCHIZOPHRENIA; WEIGHT GAIN;

EID: 42449152832     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.299.16.1899-a     Document Type: Letter

References (5)

1. Wu RR, Zhao JP, Jin H, et al. Lifestyle intervention and metformin for treatment of antipsychotic-induced weight gain: a randomized controlled trial. JAMA. 2008;299(2):185-193.
2. Ding Q, Vaynman S, Akhavan M, Ying Z, Gomez-Pinilla F. Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function. Neuroscience. 2006;140(3):823-833.
3. Fruehwald-Schultes B, Oltmanns KM, Toschek B, et al. Short-term treatment with metformin decreases serum leptin concentration without affecting body weight and body fat content in normal-weight healthy men. Metabolism. 2002;51(4):531-536.
4. Venkatasubramanian G, Chittiprol S, Neelakantachar N, et al. Insulin and insulin-like growth factor-1 abnormalities in antipsychotic-naive schizophrenia. Am J Psychiatry. 2007;164(10):1557-1560.
5. Nemet D, Connolly PH, Pontello-Pescatello AM, et al. Negative energy balance plays a major role in the IGF-I response to exercise training. J Appl Physiol. 2004;96(1):276-282.