Species scaling and extrapolation

Current Drug Metabolism

Volumn 9, Issue 3, 2008, Pages 193-198

  Gomase, Virendra S ^a   Tagore, Somnath ^a  

^a PADMASHREE DR D Y PATIL UNIVERSITY   (India)

Author keywords

Clearance; Extrapolation; Metabolism; Pharmacokinetics; Species scaling

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; BUPRENORPHINE; CYTOCHROME P450 2D6; HEXANE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NAPSAGATRAN; NITRIC OXIDE; SB 242235; SEMAXANIB; TALSACLIDINE; TOLUENE;

ALLOMETRY; ANALGESIC ACTIVITY; ANALYTIC METHOD; COMPUTER MODEL; DATA ANALYSIS; DOSIMETRY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG SCREENING; EXTRAPOLATION; HUMAN; LINEAR SYSTEM; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; METABOLOMICS; NONHUMAN; PROCESS OPTIMIZATION; REVIEW; RISK ASSESSMENT; SINGLE DRUG DOSE; SPECIES DIFFERENCE; SPECIES SCALING; TOXICITY TESTING; TREND STUDY; ANIMAL; METABOLISM; PHARMACOKINETICS; THEORETICAL MODEL;

ANIMALS; HUMANS; METABOLISM; MODELS, THEORETICAL; PHARMACOKINETICS; SPECIES SPECIFICITY;

EID: 42449151342     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920008783884786     Document Type: Review

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