Optimal contrast dose for depiction of hypervascular hepatocellular carcinoma at dynamic CT using 64-MDCT

American Journal of Roentgenology

Volumn 190, Issue 4, 2008, Pages 1003-1009

  Yanaga, Yumi ^a   Awai, Kazuo ^a   Nakaura, Takeshi ^a   Namimoto, Tomohiro ^a   Oda, Seitaro ^a   Funama, Yoshinori ^b   Yamashita, Yasuyuki ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Dynamic CT; Hepatic hemodynamics; Hepatocellular carcinoma; Liver disease; MDCT

Indexed keywords

IOPAMIDOL; CONTRAST MEDIUM;

ADULT; AGED; ARTICLE; CANCER GRADING; CONTRAST ENHANCEMENT; CONTROLLED STUDY; FEMALE; HUMAN; IMAGE ANALYSIS; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; ANALYSIS OF VARIANCE; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; LIVER TUMOR; METHODOLOGY; MIDDLE AGED; NONPARAMETRIC TEST; PROSPECTIVE STUDY; RADIOGRAPHY; RANDOMIZED CONTROLLED TRIAL; VASCULARIZATION;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; CARCINOMA, HEPATOCELLULAR; CONTRAST MEDIA; FEMALE; HUMANS; IOPAMIDOL; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; STATISTICS, NONPARAMETRIC; TOMOGRAPHY, X-RAY COMPUTED;

EID: 42449148207     PISSN: 0361803X     EISSN: None     Source Type: Journal    
DOI: 10.2214/AJR.07.3129     Document Type: Article

References (35)

1. Baron RL, Oliver JH 3rd, Dodd GD 3rd, Nalesnik M, Holbert BL, Carr B. Hepatocellular carcinoma: evaluation with biphasic, contrast-enhanced, helical CT. Radiology 1996; 199:505-511
2. Hwang GJ, Kim MJ, Yoo HS, Lee JT. Nodular hepatocellular carcinomas: detection with arterial-, portal-, and delayed-phase images at spiral CT. Radiology 1997; 202:383-388
3. Mitsuzaki K, Yamashita Y, Ogata I, Nishiharu T, Urata J, Takahashi M. Multiple-phase helical CT of the liver for detecting small hepatomas in patients with liver cirrhosis: contrast-injection protocol and optimal timing. AJR 1996; 167:753-757
4. Bae KT. Peak contrast enhancement in CT and MR angiography: when does it occur and why? Pharmacokinetic study in a porcine model. Radiology 2003; 227:809-816
5. Francis IR, Cohan RH, McNulty NJ, et al. Multidetector CT of the liver and hepatic neoplasms: effect of multiphasic imaging on tumor conspicuity and vascular enhancement. AJR 2003; 180:1217-1224 [Erratum in AJR 2003; 181:283]
6. Goshima S, Kanematsu M, Kondo H, et al. MDCT of the liver and hypervascular hepatocellular carcinomas: optimizing scan delays for bolus-tracking techniques of hepatic arterial and portal venous phases. AJR 2006; 187:W25-W32
7. Kanematsu M, Goshima S, Kondo H, et al. Optimizing scan delays of fixed duration contrast injection in contrast-enhanced biphasic multidetector-row CT for the liver and the detection of hypervascular hepatocellular carcinoma. J Comput Assist Tomogr 2005; 29:195-201
8. Kim MJ, Choi JY, Lim JS, et al. Optimal scan window for detection of hypervascular hepatocellular carcinomas during MDCT examination. AJR 2006; 187:198-206
9. Laghi A, Iannaccone R, Rossi P, et al. Hepatocellular carcinoma: detection with triple-phase multi-detector row helical CT in patients with chronic hepatitis. Radiology 2003; 226:543-549
10. Sultana S, Awai K, Nakayama Y, et al. Hypervascular hepatocellular carcinomas: bolus tracking with a 40-detector CT scanner to time arterial phase imaging. Radiology 2007; 243:140-147
11. Awai K, Hiraishi K, Hori S. Effect of contrast material injection duration and rate on aortic peak time and peak enhancement at dynamic CT involving injection protocol with dose tailored to patient weight. Radiology 2004; 230:142-150
12. Bae KT, Heiken JP, Brink JA. Aortic and hepatic peak enhancement at CT: effect of contrast medium injection rate - pharmacokinetic analysis and experimental porcine model. Radiology 1998; 206:455-464
13. Bae KT, Heiken JP, Brink JA. Aortic and hepatic contrast medium enhancement at CT. Part I. Prediction with a computer model. Radiology 1998; 207:647-655
14. Itoh S, Ikeda M, Achiwa M, Ota T, Satake H, Ishigaki T. Multiphase contrast-enhanced CT of the liver with a multislice CT scanner. Eur Radiol 2003; 13:1085-1094
15. Schima W, Hammerstingl R, Catalano C, et al. Quadruple-phase MDCT of the liver in patients with suspected hepatocellular carcinoma: effect of contrast material flow rate. AJR 2006; 186:1571-1579
16. Awai K, Takada K, Onishi H, Hori S. Aortic and hepatic enhancement and tumor-to-liver contrast: analysis of the effect of different concentrations of contrast material at multi-detector row helical CT. Radiology 2002; 224:757-763
17. Awai K, Inoue M, Yagyu Y, et al. Moderate versus high concentration of contrast material for aortic and hepatic enhancement and tumor-to-liver contrast at multi-detector row CT. Radiology 2004; 233:682-688
18. Itoh S, Ikeda M, Achiwa M, Satake H, Ota T, Ishigaki T. Multiphase contrast-enhanced CT of the liver with a multislice CT scanner: effects of iodine concentration and delivery rate. Radiat Med 2005; 23:61-69
19. Suzuki H, Oshima H, Shiraki N, Ikeya C, Shibamoto Y. Comparison of two contrast materials with different iodine concentrations in enhancing the density of the aorta, portal vein and liver at multi-detector row CT: a randomized study. Eur Radiol 2004; 14:2099-2104
20. Furuta A, Ito K, Fujita T, Koike S, Shimizu A, Matsunaga N. Hepatic enhancement in multiphasic contrast-enhanced MDCT: comparison of high- and low-iodine-concentration contrast medium in same patients with chronic liver disease. AJR 2004; 183:157-162
21. Yagyu Y, Awai K, Inoue M, et al. MDCT of hypervascular hepatocellular carcinomas: a prospective study using contrast materials with different iodine concentrations. AJR 2005; 184:1535-1540
22. Yamashita Y, Komohara Y, Takahashi M, et al. Abdominal helical CT: evaluation of optimal doses of intravenous contrast material - a prospective randomized study. Radiology 2000; 216:718-723
23. Baron RL. Understanding and optimizing use of contrast material for CT of the liver. AJR 1994; 163:323-331
24. Lim JH, Kim EY, Lee WJ, et al. Regenerative nodules in liver cirrhosis: findings at CT during arterial portography and CT hepatic arteriography with histopathologic correlation. Radiology 1999; 210:451-458
25. Svanholm H, Starklint H, Gundersen HJ, Fabricius J, Barlebo H, Olsen S. Reproducibility of histomorphologic diagnoses with special reference to the kappa statistic. APMIS 1989; 97:689-698
26. MEPHAS Website. www.gen-info.osaka-u.ac.jp/testdocs/tomocom/. Accessed March 13, 2007
27. Kim T, Murakami T, Takahashi S, et al. Effects of injection rates of contrast material on arterial phase hepatic CT. AJR 1998; 171:429-432
28. Lee KH, Choi BI, Han JK, Jang HJ, Kim TK, Han MC. Nodular hepatocellular carcinoma: variation of tumor conspicuity on single-level dynamic scan and optimization of fixed delay times for twophase helical CT. J Comput Assist Tomogr 2000; 24:212-218
29. Ichikawa T, Nakajima H, Nanbu A, Hori M, Araki T. Effect of injection rate of contrast material on CT of hepatocellular carcinoma. AJR 2006; 186:1413-1418
30. Kim T, Murakami T, Hori M, et al. Small hypervascular hepatocellular carcinoma revealed by double arterial phase CT performed with single breath-hold scanning and automatic bolus tracking. AJR 2002; 178:899-904
31. Murakami T, Kim T, Takamura M, et al. Hypervascular hepatocellular carcinoma: detection with double arterial phase multi-detector row helical CT. Radiology 2001; 218:763-767
32. Yanaga Y, Awai K, Nakayama Y, et al. Optimal dose and injection duration (injection rate) of contrast material for depiction of hypervascular hepatocellular carcinomas by multidetector CT. Radiat Med 2007; 25:278-288
33. Awai K, Nakayama Y, Nakaura T, et al. Prediction of aortic peak enhancement in monophasic contrast injection protocols at multidetector CT: phantom and patient studies. Radiat Med 2007; 25:14-21
34. Heiken JP, Brink JA, McClennan BL, Sagel SS, Crowe TM, Gaines MV. Dynamic incremental CT: effect of volume and concentration of contrast material and patient weight on hepatic enhancement. Radiology 1995; 195:353-357
35. Obuchowski NA. Receiver operating characteristic curves and their use in radiology. Radiology 2003; 229:3-8