Isolation and characterization of ACTX-6: A cytotoxic L-amino acid oxidase from Agkistrodon acutus snake venom

Natural Product Research

Volumn 22, Issue 6, 2008, Pages 554-563

  Zhang, L ^a,b   Wu, W T ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

Author keywords

ACTX 6; Cytotoxin; L amino acid oxidase (LAAO); Snake venom

Indexed keywords

ACTX 6; AMINO ACID OXIDASE; ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; SNAKE VENOM; UNCLASSIFIED DRUG;

AGKISTRODON; AGKISTRODON ACUTUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CHROMATOGRAPHY; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DRUG ISOLATION; DRUG PURIFICATION; DRUG SCREENING; DRUG STRUCTURE; ENZYME SUBSTRATE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MASS SPECTROMETRY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; TUMOR;

AGKISTRODON; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CROTALID VENOMS; FEMALE; FLOW CYTOMETRY; HUMANS; L-AMINO ACID OXIDASE; MALE; MICE; MOLECULAR WEIGHT; UTERINE CERVICAL NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

DEINAGKISTRODON ACUTUS;

EID: 42449138183     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/14786410701592679     Document Type: Article

References (24)

1. Du, XY and Clemetson, KJ (2002) Snake venom-amino acid oxidase, Toxicon, p. 659.
2. Stabeli, RG, Marcussi, S., Carlos, GB, Pietro, RCLR, Selistre-de-Araujo, HS, Giglio, JR, Oliveira, EB and Soares, AM (2004) Bioorg. Med. Chem., 11, p. 2881.
3. Zhang, H., Yang, Q., Sun, M., Teng, M. and Niu, L. (2004) J. Microbiol., 4, p. 336.
4. Suhr, SM and Kim, DS (1996) Biophys. Res. Commun., 1, p. 134.
5. Sun, LK, Yoshii, Y., Hyodo, A., Tsurushima, A., Saita, A., Harakuni, T., Li, YP, Kariya, K., Nozaki, M. and Morine, N. (2003) Toxicol. In Vitro, 2, p. 169.
6. Zhang, YJ, Wang, JH, Lee, WH, Wang, Q., Liu, H., Zheng, YT and Zhang, Y. (2003) Biochem. Biophys. Res. Commun., 3, p. 598.
7. Torii, S., Naito, M. and Tsuruo, T. (1997) J. Biol. Chem., 14, p. 9539.
8. Cheng, X., Qian, Y., Liu, Q., Benjamin, XYL, Zhang, M. and Liu, J. (1999) Biochem. Biophys. Res. Commun., 2, p. 530.
9. Huang, QQ, Teng, MK and Niu, LW (1999) Toxicon, 7, p. 999.
10. Xu, XL, Liu, QL, Wu, B. and Xie, YS (2000) Biopolymers, 6, p. 1517.
11. Samel, M., Vija, H., Rönnholm, G., Siigur, J., Kalkkinen, N. and Siigur, E. (2006) Biochim. Biophys. Acta, 4, p. 707.
12. Scudiero, DA, Shoemaker, RH, Paull, KD, Monks, A., Tierney, S., Nofziger, TH, Currens, MJ, Seniff, D. and Boyd, MR (1988) Cancer Res., 17, p. 4827.
13. Marzano, C., Bettio, F., Baccichetti, F., Trevisan, A., Giovagnini, L. and Fregona, D. (2004) Chem. Biol. Interact., 148:1, p. 37.
14. Tan, NH (1998) L-amino acid oxidase and lactate dehydrogenases. Enzymes From Snake Venom, pp. 579-598. Alaken Inc., Fort Collins, CO
15. Iwanaga, S. and Suzuki, T. (1979) Enzymes in snake venom. Snake venoms, pp. 61-158. Springer, Berlin-Heidelberg, New York
16. Kanzawa, N., Shintani, S., Ohta, K., Kitajima, S., Ehara, T., Kobayashi, H., Kizaki, H. and Tsuchiya, T. (2004) Archives of Biochemistry and Biophysics, 422, p. 103.
17. Ali, SA, Stoeva, S., Abbasi, A., Alam, JM, Kaved, R., Faigle, M., Neumeister, B. and Voelter, W. (2000) Archives of biochemistry and biophysics, 384, p. 216.
18. Ander, SR, Kommoju, PR, Draxl, S., Murkovic, M., Macheroux, P., Ghisla, S. and Ferrando-Mav, E. (2006) Apoptosis, 11, p. 1439.
19. Sun, LK, Yoshii, Y., Hyodo, A., Tsurushima, H., Saito, A., Harakuni, T., Li, YP, Kariya, K., Nozaki, M. and Morine, N. (2003) Toxicology in vitro, 17, p. 169.
20. Skulachev, VP (1996) FEBS Letters, 397, p. 7.
21. Skulachev, VP (2002) Annals of the New York Academy of Sciences, 959, p. 214.
22. Costantini, P., Jocotot, E., Decaudin, D. and Kroemer, G. (2000) J. National Cancer Institute, 92, p. 1042.
23. Fontaine, E. and Bernardi, P. (1999) J. Bioenerget. Biomembran., 31, p. 335.
24. Zoratti, M. and Szabò, I. (1995) Biochimica et Biophysica Acta, 1241, p. 139.