Insulin-like growth factor binding protein-2: A novel regulator of skeletal gender differences?

Endocrinology

Volumn 149, Issue 5, 2008, Pages 2048-2050

  Khosla, Sundeep ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; INSULIN LIKE GROWTH FACTOR 2E; INTEGRIN RECEPTOR; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN C; TENSIN; UNCLASSIFIED DRUG;

AGING; BINDING AFFINITY; BONE BIOPSY; BONE GROWTH; BONE MASS; BONE MATRIX; BONE STRUCTURE; BONE TURNOVER; CHROMOSOME 10; CHROMOSOME DELETION; COMPUTER ASSISTED TOMOGRAPHY; DISEASE ASSOCIATION; ENZYME ACTIVITY; HEPATITIS C; HUMAN; NONHUMAN; OSTEOBLAST; OSTEOSCLEROSIS; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN TARGETING; SEX DIFFERENCE; SHORT SURVEY; SIGNAL TRANSDUCTION; TRABECULAR BONE;

ANIMALS; BONE AND BONES; BONE DENSITY; BONE DEVELOPMENT; FEMALE; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; MALE; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; ORGAN SIZE; SEX CHARACTERISTICS;

EID: 42449132261     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-0174     Document Type: Short Survey

References (10)

1. Aaron JE, Makins NB, Sagreiya K 1987 The microanatomy of trabecular bone loss in normal aging men and women. Clin Orthop 215:260-271
2. Khosla S, Riggs BL, Atkinson EJ, Oberg AL, McDaniel LJ, Holets M, Peterson JM, Melton III LJ 2006 Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment. J Bone Miner Res 21:124-131
3. DeMambro VE, Clemmons DR, Horton LG, Bouxsein ML, Wood TL, Beamer WG, Canalis E, Rosen CJ 2008 Gender-specific changes in bone turnover and skeletal architecture in Igfbp-2-null mice. Endocrinology 149:0000-0000
4. Khosla S, Hassoun AAK, Baker BK, Liu F, Zein NN, Whyte MP, Reasner CA, Nippoldt TB, Tiegs RD, Hintz RL, Conover CA 1998 Insulin-like growth factor system abnormalities in hepatitis C-associated osteosclerosis. J Clin Invest 101:2165-2173
5. Conover CA, Johnstone EW, Turner RT, Evans GL, Ballard FJ, Doran PM, Khosla S 2002 Subcutaneous administration of insulin-like growth factor (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis. Growth Horm IGF Res 12:178-183
6. Aria T, Busby WJ, Clemmons DR 1996 Binding of insulin-like growth factor (IGF-I) or II to IGF-binding protein-2 enables it to bind to heparin and extracellular matrix. Endocrinology 137:4571-4575
7. 2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells. Am J Physiol Endocrinol Metab 290:E952-E960
8. Mehrian-Shai R, Chen CD, Shi T, Horvath S, Nelson SF, Reichardt JKV, Sawyers CL 2007 Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer. Proc Natl Acad Sci USA 104:5563-5568
9. Perks CM, Vernon EG, Rosendahl AH, Tonge D, Holly JMP 2007 IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells. Oncogene 26:5966-5972
10. Liu X, Bruxvoort KJ, Zylstra CR, Liu J, Cichowski R, Faugere M-C, Bouxsein ML, Wan C, Williams BO, Clemens TL 2007 Lifelong accumulation of bone in mice lacking Pten in osteoblasts. Proc Natl Acad Sci USA 104:2259-2264