In situ delivery of bone marrow cells and mesenchymal stem cells improves cardiovascular function in hypertensive rats submitted to myocardial infarction

Journal of Biomedical Science

Volumn 15, Issue 3, 2008, Pages 365-374

  De Macedo Braga, Luisa Maria Gomes ^a,b   Lacchini, Silvia ^c   Schaan, Beatriz D'Agord ^d   Rodrigues, Bruno ^c   Rosa, Kaleizu ^c   De Angelis, Kátia ^c   Borges, Luciano Figueiredo ^c   Irigoyen, Maria Cláudia ^c   Nardi, Nance Beyer ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b Rio Grande do Sul State Health Department   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d PROCAD Cardiology Institute   (Brazil)

Author keywords

Bone marrow cells; Hypertension; In situ delivery; Mesenchymal stem cells; Spontaneously hypertensive rats

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CAPILLARY DENSITY; CARDIOVASCULAR FUNCTION; CELL CULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; ECHOCARDIOGRAPHY; HEART EJECTION FRACTION; HEART INFARCTION; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE; HISTOLOGY; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MORPHOLOGY; MUSCLE CELL; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SURVIVAL RATE; Y CHROMOSOME;

ANIMALS; BASE SEQUENCE; BONE MARROW CELLS; CARDIOVASCULAR SYSTEM; CELL TRANSPLANTATION; DISEASE MODELS, ANIMAL; DNA PRIMERS; ECHOCARDIOGRAPHY; FEMALE; HYPERTENSION; IMMUNOPHENOTYPING; MESENCHYMAL STEM CELLS; MYOCARDIAL INFARCTION; POLYMERASE CHAIN REACTION; RATS; RATS, INBRED SHR;

ANIMALIA; RATTUS;

EID: 42449129618     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1007/s11373-008-9237-z     Document Type: Article

References (34)

1. Ridker PM, Stampfer MJ, Rifai N (2001) Novel risk factors for systemic atherosclerosis: a comparison of c-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease. JAMA 285:2481-2485
2. Doggrell SA, Brown L (1998) Rat models of hypertension, cardiac hypertrophy and failure. Cardiovasc Res 39:89-105
3. Nishikimi T, Yamagishi H, Takeuchi K, Takeda T (1995) An angiotensin II receptor antagonist attenuates left ventricular dilatation after myocardial infarction in the hypertensive rat. Cardiovasc Res 29:856-861
4. Wollert KC, Drexler H (2006) Cell-based therapy for heart failure. Curr Opin Cardiol 21:234-239
5. Becker C, Lacchini S, Muotri AR, da Silva GJ, Castelli JB, Vassallo PF, Menck CF, Krieger JE (2006) Skeletal muscle cells expressing VEGF induce capillary formation and reduce cardiac injury in rats. Int J Cardiol 113:348-354
6. Kucia M, Ratajczak J, Reca R, Janowska-Wieczorek A, Ratajczak MZ (2004) Tissue-specific muscle, neural and liver stem/progenitor cells reside in the bone marrow, respond to an SDF-1 gradient and are mobilized into peripheral blood during stress and tissue injury. Blood Cells Mol Dis 32:52-57
7. Lin F, Cordes K, Li L, Hood L, Couser WG, Shankland SJ, Igarashi P (2003) Hematopoietic stem cells contribute to the regeneration of renal tubules after renal ischemia-reperfusion injury in mice. J Am Soc Nephrol 14:1188-1199
8. Rehman J, Li J, Orschell CM, March KL (2003) Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation 107:1164-1169
9. Zhang FB, Li L, Fang B, Zhu DL, Yang HT, Gao PJ (2005) Passage-restricted differentiation potential of mesenchymal stem cells into cardiomyocyte-like cells. Biochem Biophys Res Commun 336:784-792
10. Amado LC, Saliaris AP, Schuleri KH, St John M, Xie JS, Cattaneo S, Durand DJ, Fitton T, Kuang JQ, Stewart G, Lehrke S, Baumgartner WW, Martin BJ, Heldman AW, Hare JM (2005) Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci USA 102:11474-11479
11. Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, Nadal-Ginard B, Bodine DM, Leri A, Anversa P (2001) Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci USA 98:10344-10349
12. Boomsma RA, Swaminathan PD, Geenen DL (2006) Intravenously injected mesenchymal stem cells home to viable myocardium after coronary occlusion and preserve systolic function without altering infarct size. Int J Cardiol [Epub ahead of print]
13. Kinnaird T, Stabile E, Burnett MS, Shou M, Lee CW, Barr S, Fuchs S, Epstein SE (2004) Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation 109:1543-1549
14. Nagaya N, Fujii T, Iwase T, Ohgushi H, Itoh T, Uematsu M, Yamagishi M, Mori H, Kangawa K, Kitamura K (2004) Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol 287:H2670-H2676
15. Davani S, Marandin A, Mersin N, Royer B, Kantelip B, Herve P, Etievent JP, Kantelip JP (2003) Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model. Circulation 108(Suppl 1):II253-II258
16. Shyu KG, Wang BW, Hung HF, Chang CC, Shih DT (2006) Mesenchymal stem cells are superior to angiogenic growth factor genes for improving myocardial performance in the mouse model of acute myocardial infarction. J Biomed Sci 13:47-58
17. Meirelles Lda S, Nardi NB (2003) Murine marrow-derived mesenchymal stem cell: isolation, in vitro expansion, and characterization. Br J Haematol 123:702-711
18. Da Silva Meirelles L, Chagastelles PC, Nardi NB (2006) Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 119:2204-2213
19. De Angelis K, Leirner AA, Irigoyen MC, Cestari IA (2001) Nonstimulated cardiomyoplasty improves hemodynamics in myocardial-infarcted rats. Artif Organs 25:939-943
20. Johns TN, Olson BJ (1954) Experimental myocardial infarction. I. A method of coronary occlusion in small animals. Ann Surg 140:675-682
21. Nozawa E, Kanashiro RM, Murad N, Carvalho AC, Cravo SL, Campos O, Tucci PJ, Moises VA (2006) Performance of two-dimensional Doppler echocardiography for the assessment of infarct size and left ventricular function in rats. Braz J Med Biol Res 39:687-695
22. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual, 2nd edn. Cold Spring Harbor, Cold Spring Harbor Laboratory Press, New York
23. Beyer Nardi N, da Silva Meirelles L (2006) Mesenchymal stem cells: isolation, in vitro expansion and characterization. Handbook Exp Pharmacol 174:249-282
24. Kudo M, Wang Y, Wani MA, Xu M, Ayub A, Ashraf M (2003) Implantation of bone marrow stem cells reduces the infarction and fibrosis in ischemic mouse heart. J Mol Cell Cardiol 35:1113-1119
25. Lovell MJ, Mathur A (2004) The role of stem cells for treatment of cardiovascular disease. Cell Prolif 37:67-87
26. Zdrojewski T, Gaudron P, Whittaker P, Poelzl S, Schiemann J, Hu K, Ertl G (2002) Ventricular remodeling after myocardial infarction and effects of ACE inhibition on hemodynamics and scar formation in SHR. Cardiovasc Pathol 11:88-93
27. Pfeffer J, Pfeffer M, Fletcher P, Braunwald E (1979) Alterations of cardiac performance in rats with established spontaneous hypertension. Am J Cardiol 44:994-998
28. Wollert KC, Drexler H (2004) Cell therapy for acute myocardial infarction: where are we heading? Nat Clin Pract Cardiovasc Med 1:61
29. Fukushima S, Varela-Carver A, Coppen SR, Yamahara K, Felkin LE, Lee J, Barton PJ, Terracciano CM, Yacoub MH, Suzuki K (2007) Direct intramyocardial but not intracoronary injection of bone marrow cells induces ventricular arrhythmias in a rat chronic ischemic heart failure model. Circulation 115:2254-2261
30. Wang XJ, Li QP (2007) The roles of mesenchymal stem cells (MSCs) therapy in ischemic heart diseases. Biochem Biophys Res Commun 359:189-193
31. Iso Y, Spees JL, Serrano C, Bakondi B, Pochampally R, Song YH, Sobel BE, Delafontaine P, Prockop DJ (2007) Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment. Biochem Biophys Res Commun 354:700-706
32. Noiseux N, Gnecchi M, Lopez-Ilasaca M, Zhang L, Solomon SD, Deb A, Dzau VJ, Pratt RE (2006) Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. Mol Ther 14:840-850
33. Sze SK, de Kleijn DP, Lai RC, Tan EK, Zhao H, Yeo KS, Low TY, Lian Q, Lee CN, Mitchell W, El Oakley RM, Lim SK (2007) Elucidating the secretion proteome of human ESC-derived mesenchymal stem cells. Mol Cell Proteomics [Epub ahead of print]
34. Braga LMGM, Rosa K, Rodrigues B, Malfitano C, Camassola M, Chagastelles P, Lacchini S, Fiorino P, De Angelis K, Schaan B, Irigoyen MC, Nardi NB (2007) Systemic delivery of adult stem cells improves cardiac function in spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 35; [Epub ahead of print]