The RGS gene loco is essential for male reproductive system differentiation in Drosophila melanogaster

BMC Developmental Biology

Volumn 8, Issue , 2008, Pages

  McGurk, Leeanne ^a   Pathirana, Stephen ^b   Rothwell, Kathleen ^c   Trimbuch, Thorsten ^d   Colombini, Paolo ^e   Yu, Fengwei ^f   Chia, William ^f   Bownes, Mary ^c  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

^b EUROPEAN COMMISSION   (Belgium)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e National University of Singapore ^*  (Italy)

^f NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; DROSOPHILA PROTEIN; G PROTEIN COUPLED RECEPTOR; ISOPROTEIN; LOCO PROTEIN, DROSOPHILA; NERVE PROTEIN;

ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENETIC SCREENING; GENETIC TRANSCRIPTION; GONAD DEVELOPMENT; HUMAN; LOCO GENE; MALE FERTILITY; MALE GENITAL SYSTEM; MALE STERILITY; METAMORPHOSIS; MORPHOGENESIS; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN BINDING; PROTEIN EXPRESSION; PUPA (LIFE CYCLE STAGE); REGULATOR GENE; TESTIS; WILD TYPE; ANIMAL; DNA SEQUENCE; GENE EXPRESSION REGULATION; GENETIC COMPLEMENTATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; MALE; MALE INFERTILITY; MUTATION; POLYMERASE CHAIN REACTION;

DROSOPHILA MELANOGASTER;

ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC COMPLEMENTATION TEST; GENITALIA, MALE; INFERTILITY, MALE; MALE; METAMORPHOSIS, BIOLOGICAL; MUTATION; NERVE TISSUE PROTEINS; PHENOTYPE; POLYMERASE CHAIN REACTION; PROTEIN ISOFORMS; RECEPTORS, G-PROTEIN-COUPLED; SEQUENCE ANALYSIS, DNA;

EID: 42449122992     PISSN: None     EISSN: 1471213X     Source Type: Journal    
DOI: 10.1186/1471-213X-8-37     Document Type: Article

References (37)

1. GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain. L De Vries M Mousli A Wurmser MG Farquhar, Proc Natl Acad Sci U S A 1995 92 25 11916 11920 8524874 10.1073/pnas.92.25.11916
2. Regulators of G-protein signalling as new central nervous system drug targets. RR Neubig DP Siderovski, Nat Rev Drug Discov 2002 1 3 187 197 10.1038/nrd747 12120503
3. GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. DM Berman TM Wilkie AG Gilman, Cell 1996 86 3 445 452 10.1016/S0092-8674(00)80117-8 8756726
4. RGS10 is a selective activator of G alpha i GTPase activity. TW Hunt TA Fields PJ Casey EG Peralta, Nature 1996 383 6596 175 177 10.1038/383175a0 8774883
5. Identification and functional analysis of the Drosophila gene loco. S Granderath C Klambt, Methods Enzymol 2004 389 350 363 15313576
6. A Drosophila Axin homolog, Daxin, inhibits Wnt signaling. K Willert CY Logan A Arora M Fish R Nusse, Development 1999 126 18 4165 4173 10457025
7. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. C Liu Y Li M Semenov C Han GH Baeg Y Tan Z Zhang X Lin X He, Cell 2002 108 6 837 847 10.1016/S0092-8674(02)00685-2 11955436
8. Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. MJ Hart R de los Santos IN Albert B Rubinfeld P Polakis, Curr Biol 1998 8 10 573 581 10.1016/S0960-9822(98) 70226-X 9601641
9. The Wnt signaling pathway in development and disease. CY Logan R Nusse, Annu Rev Cell Dev Biol 2004 20 781 810 10.1146/annurev.cellbio.20.010403.113126 15473860
10. Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. MD Castellone H Teramoto BO Williams KM Druey JS Gutkind, Science 2005 310 5753 1504 1510 10.1126/science.1116221 16293724
11. Gprk2 controls cAMP levels in Drosophila development. BJ Lannutti LE Schneider, Dev Biol 2001 233 1 174 185 10.1006/dbio.2001.0219 11319866
12. The Drosophila G-protein-coupled receptor kinase homologue Gprk2 is required for egg morphogenesis. LE Schneider AC Spradling, Development 1997 124 13 2591 2602 9217001
13. Locomotion defects, together with Pins, regulates heterotrimeric G-protein signaling during Drosophila neuroblast asymmetric divisions. F Yu H Wang H Qian R Kaushik M Bownes X Yang W Chia, Genes Dev 2005 19 11 1341 1353 15937221 10.1101/gad.1295505
14. loco encodes an RGS protein required for Drosophila glial differentiation. S Granderath A Stollewerk S Greig CS Goodman CJ O'Kane C Klambt, Development 1999 126 8 1781 1791 10079238
15. The Drosophila RGS protein Loco is required for dorsal/ventral axis formation of the egg and embryo, and nurse cell dumping. S Pathirana D Zhao M Bownes, Mech Dev 2001 109 2 137 150 10.1016/S0925-4773(01)00557-3 11731228
16. Restricted spatial and temporal expression of G-protein alpha subunits during Drosophila embryogenesis. WJ Wolfgang F Quan N Thambi M Forte, Development 1991 113 2 527 538 1782864
17. A Drosophila melanogaster G protein alpha subunit gene is expressed primarily in embryos and pupae. NM Provost DE Somers JB Hurley, J Biol Chem 1988 263 24 12070 12076 3136172
18. The heterotrimeric protein Go is required for the formation of heart epithelium in Drosophila. F Fremion M Astier S Zaffran A Guillen V Homburger M Semeriva, J Cell Biol 1999 145 5 1063 1076 10.1083/jcb.145.5.1063 10352022
19. Immunological and molecular characterization of Go alpha-like proteins in the Drosophila central nervous system. NC Thambi F Quan WJ Wolfgang A Spiegel M Forte, J Biol Chem 1989 264 31 18552 18560 2509464
20. Immunolocalization of G protein alpha-subunits in the Drosophila CNS. WJ Wolfgang F Quan P Goldsmith C Unson A Spiegel M Forte, J Neurosci 1990 10 3 1014 1024 2108229
21. Dual roles for the trimeric G protein Go in asymmetric cell division in Drosophila. VL Katanaev A Tomlinson, Proc Natl Acad Sci U S A 2006 103 17 6524 6529 16617104 10.1073/pnas.0601853103
22. The Drosophila Go alpha-like G protein gene produces multiple transcripts and is expressed in the nervous system and in ovaries. SM de Sousa LL Hoveland S Yarfitz JB Hurley, J Biol Chem 1989 264 31 18544 18551 2509463
23. A Drosophila G-protein alpha subunit, Gf alpha, expressed in a spatially and temporally restricted pattern during Drosophila development. F Quan WJ Wolfgang M Forte, Proc Natl Acad Sci U S A 1993 90 9 4236 4240 7683429 10.1073/pnas.90.9.4236
24. dgq: a drosophila gene encoding a visual system-specific G alpha molecule. YJ Lee MB Dobbs ML Verardi DR Hyde, Neuron 1990 5 6 889 898 10.1016/0896-6273(90)90349-K 2125225
25. G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates. M Strathmann MI Simon, Proc Natl Acad Sci U S A 1990 87 23 9113 9117 2123549 10.1073/pnas.87.23.9113
26. Novel Gq alpha isoform is a candidate transducer of rhodopsin signaling in a Drosophila testes-autonomous pacemaker. CE Alvarez K Robison W Gilbert, Proc Natl Acad Sci U S A 1996 93 22 12278 12282 8901571 10.1073/pnas.93.22.12278
27. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. MR Koelle HR Horvitz, Cell 1996 84 1 115 125 10.1016/S0092-8674(00)80998-8 8548815
28. Molecular cloning and expression analysis of rat Rgs12 and Rgs14. BE Snow L Antonio S Suggs HB Gutstein DP Siderovski, Biochem Biophys Res Commun 1997 233 3 770 777 10.1006/bbrc.1997.6537 9168931
29. GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. BE Snow RA Hall AM Krumins GM Brothers D Bouchard CA Brothers S Chung J Mangion AG Gilman RJ Lefkowitz DP Siderovski, J Biol Chem 1998 273 28 17749 17755 10.1074/jbc.273.28.17749 9651375
30. A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. BE Snow AM Krumins GM Brothers SF Lee MA Wall S Chung J Mangion S Arya AG Gilman DP Siderovski, Proc Natl Acad Sci U S A 1998 95 22 13307 13312 9789084 10.1073/pnas.95.22.13307
31. RGS9: a regulator of G-protein signalling with specific expression in rat and mouse striatum. EA Thomas PE Danielson JG Sutcliffe, J Neurosci Res 1998 52 1 118 124 10.1002/(SICI)1097-4547(19980401)52:1<118::AID-JNR11>3.0.CO;2-6 9556034
32. Posterior localization of the Drosophila Gi alpha protein during early embryogenesis requires a subset of the posterior group genes. WJ Wolfgang M Forte, Int J Dev Biol 1995 39 4 581 586 8619956
33. A targeted gene silencing technique shows that Drosophila myosin VI is required for egg chamber and imaginal disc morphogenesis. W Deng K Leaper M Bownes, J Cell Sci 1999 112 ( Pt 21) 3677 3690 10523504
34. SMART, a simple modular architecture research tool: identification of signaling domains. J Schultz F Milpetz P Bork CP Ponting, Proc Natl Acad Sci U S A 1998 95 11 5857 5864 9600884 10.1073/pnas.95.11.5857
35. CDD: a Conserved Domain Database for protein classification. A Marchler-Bauer JB Anderson PF Cherukuri C DeWeese-Scott LY Geer M Gwadz S He DI Hurwitz JD Jackson Z Ke CJ Lanczycki CA Liebert C Liu F Lu GH Marchler M Mullokandov BA Shoemaker V Simonyan JS Song PA Thiessen RA Yamashita JJ Yin D Zhang SH Bryant, Nucleic Acids Res 2005 33 Database issue D192 6 15608175 10.1093/nar/gki069
36. ClustalW. http://www.ebi.ac.uk/Tools/clustalw2/index.html
37. BoxShade. http://www.ch.embnet.org/software/BOX_form.html