MEK/ERK pathway inhibitors as a treatment for inflammatory arthritis might result in the development of lupus: Comment on the article by Thiel et al

Arthritis and Rheumatism

Volumn 58, Issue 4, 2008, Pages 1203-1204

  Sawalha, Amr H ^a   Richardson, Bruce ^b  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR;

ANTIGEN PRESENTING CELL; ARTHRITIS; CD4+ T LYMPHOCYTE; DISEASE ACTIVITY; ENZYME INHIBITION; GENE OVEREXPRESSION; LETTER; LUPUS VULGARIS; METHYLATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; INFLAMMATION; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; SIGNAL TRANSDUCTION;

EID: 42449122557     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.23382     Document Type: Letter

References (9)

1. Thiel MJ, Schaefer CJ, Lesch ME, Mobley JL, Dudley DT, Tecle H, et al. Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms. Arthritis Rheum 2007;56:3347-57.
2. Deng C, Yang J, Scott J, Hanash S, Richardson BC. Role of the ras-MAPK signaling pathway in the DNA methyltransferase response to DNA hypomethylation. Biol Chem 1998;379:1113-20.
3. Deng C, Kaplan MJ, Yang J, Ray D, Zhang Z, McCune WJ, et al. Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients. Arthritis Rheum 2001;44:397-407.
4. Sawalha AH, Richardson BC. DNA methylation in the pathogenesis of systemic lupus erythematosus. Cur Pharmacogenomics 2005; 3:73-8.
5. Lu Q, Wu A, Tesmer L, Ray D, Yousif N, Richardson B. Demethylation of CD40LG on the inactive X in T cells from women with lupus. J Immunol 2007;179:6352-8.
6. Deng C, Lu Q, Zhang Z, Rao T, Attwood J, Yung R, et al. Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling. Arthritis Rheum 2003; 48:746-56.
7. Oelke K, Lu Q, Richardson D, Wu A, Deng C, Hanash S, et al. Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors. Arthritis Rheum 2004;50:1850-60.
8. Yung RL, Quddus J, Chrisp CE, Johnson KJ, Richardson BC. Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo. J Immunol 1995;154:3025-35.
9. Cornacchia E, Golbus J, Maybaum J, Strahler J, Hanash S, Richardson B. Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J Immunol 1988;140: 2197-200.