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Volumn 7, Issue 7, 2008, Pages 874-878

The cytoprotective Nrf2 transcription factor controls insulin receptor signaling in the regenerating liver

Author keywords

IGF 1; Insulin; Liver regeneration; Nrf2; Oxidative stress; PI3K; ROS

Indexed keywords

INSULIN; INSULIN RECEPTOR; SOMATOMEDIN C; TRANSCRIPTION FACTOR NRF2;

EID: 42449110757     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.7.7.5617     Document Type: Review
Times cited : (39)

References (55)
  • 1
    • 0034007745 scopus 로고    scopus 로고
    • Liver regeneration
    • Fausto N. Liver regeneration. J Hepatol 2000; 32:19-31.
    • (2000) J Hepatol , vol.32 , pp. 19-31
    • Fausto, N.1
  • 3
    • 0029049780 scopus 로고
    • Rapid activation of the Stat3 transcription complex in liver regeneration
    • Cressman D, Diamond R, Taub R. Rapid activation of the Stat3 transcription complex in liver regeneration. Hepatology 1995; 21:1443-9.
    • (1995) Hepatology , vol.21 , pp. 1443-1449
    • Cressman, D.1    Diamond, R.2    Taub, R.3
  • 4
    • 0028914369 scopus 로고
    • Rapid DNA binding by nuclear factor kappa B in hepatocytes at the start of liver regeneration
    • FitzGerald M, Webber E, Donovan J, Fausto N. Rapid DNA binding by nuclear factor kappa B in hepatocytes at the start of liver regeneration. Cell Growth Differ 1995; 6:417-27.
    • (1995) Cell Growth Differ , vol.6 , pp. 417-427
    • FitzGerald, M.1    Webber, E.2    Donovan, J.3    Fausto, N.4
  • 5
    • 0030815757 scopus 로고    scopus 로고
    • Specific activation of AP-1 but not Stat3 in regenerating liver in mice
    • Heim M, Gamboni G, Beglinger C, Gyr K. Specific activation of AP-1 but not Stat3 in regenerating liver in mice. Eur J Clin Invest 1997; 27:948-55.
    • (1997) Eur J Clin Invest , vol.27 , pp. 948-955
    • Heim, M.1    Gamboni, G.2    Beglinger, C.3    Gyr, K.4
  • 7
    • 1842428601 scopus 로고    scopus 로고
    • Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair
    • Huh C, Factor V, Sanchez A, Uchida K, Conner E, Thorgeirsson S. Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci USA 2004; 101:4477-82.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4477-4482
    • Huh, C.1    Factor, V.2    Sanchez, A.3    Uchida, K.4    Conner, E.5    Thorgeirsson, S.6
  • 8
    • 0041531109 scopus 로고
    • Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism
    • Mead J, Fausto N. Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism. Proc Natl Acad Sci USA 1989; 86:1558-62.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 1558-1562
    • Mead, J.1    Fausto, N.2
  • 9
    • 36048973747 scopus 로고    scopus 로고
    • The EGF receptor is required for efficient liver regeneration
    • Natarajan A, Wagner B, Sibilia M. The EGF receptor is required for efficient liver regeneration. Proc Natl Acad Sci USA 2007; 104:17081-6.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 17081-17086
    • Natarajan, A.1    Wagner, B.2    Sibilia, M.3
  • 12
    • 7044228192 scopus 로고    scopus 로고
    • Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice
    • Oe S, Lemmer E, Conner E, Factor V, Leveen P, Larsson J, Karlsson S, Thorgeirsson S. Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice. Hepatology 2004; 40:1098-105.
    • (2004) Hepatology , vol.40 , pp. 1098-1105
    • Oe, S.1    Lemmer, E.2    Conner, E.3    Factor, V.4    Leveen, P.5    Larsson, J.6    Karlsson, S.7    Thorgeirsson, S.8
  • 13
    • 0037256608 scopus 로고    scopus 로고
    • Hepatotoxicity and mechanism of action of haloalkanes: Carbon tetrachloride as a toxicological model
    • Weber LW, Boll M, Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol 2003; 33:105-36.
    • (2003) Crit Rev Toxicol , vol.33 , pp. 105-136
    • Weber, L.W.1    Boll, M.2    Stampfl, A.3
  • 14
    • 0034869459 scopus 로고    scopus 로고
    • Oxidative stress-related molecules and liver fibrosis
    • Parola M, Robino G. Oxidative stress-related molecules and liver fibrosis. J Hepatol 2001; 35:297-306.
    • (2001) J Hepatol , vol.35 , pp. 297-306
    • Parola, M.1    Robino, G.2
  • 15
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000; 275:2247-50.
    • (2000) J Biol Chem , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 16
    • 0028197170 scopus 로고
    • Free radicals in cutaneous biology
    • Darr D, Fridovich I. Free radicals in cutaneous biology. J Invest Dermatol 1994; 102:671-5.
    • (1994) J Invest Dermatol , vol.102 , pp. 671-675
    • Darr, D.1    Fridovich, I.2
  • 17
    • 1942520367 scopus 로고    scopus 로고
    • Jaiswal A. Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic Biol Med 2004; 36:1199-207.
    • Jaiswal A. Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic Biol Med 2004; 36:1199-207.
  • 18
    • 3142570440 scopus 로고    scopus 로고
    • The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress
    • Nguyen T, Yang C, Pickett C. The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress. Free Radic Biol Med 2004; 37:433-41.
    • (2004) Free Radic Biol Med , vol.37 , pp. 433-441
    • Nguyen, T.1    Yang, C.2    Pickett, C.3
  • 19
    • 1942455887 scopus 로고    scopus 로고
    • Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles
    • Itoh K, Tong K, Yamamoto M. Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic Biol Med 2004; 36:1208-13.
    • (2004) Free Radic Biol Med , vol.36 , pp. 1208-1213
    • Itoh, K.1    Tong, K.2    Yamamoto, M.3
  • 20
    • 4544294365 scopus 로고    scopus 로고
    • The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase
    • Cullinan S, Gordan J, Jin J, Harper J, Diehl J. The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. Mol Cell Biol 2004; 24:8477-86.
    • (2004) Mol Cell Biol , vol.24 , pp. 8477-8486
    • Cullinan, S.1    Gordan, J.2    Jin, J.3    Harper, J.4    Diehl, J.5
  • 21
    • 3543008924 scopus 로고    scopus 로고
    • Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
    • Kobayashi A, Kang M, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 2004; 24:7130-9.
    • (2004) Mol Cell Biol , vol.24 , pp. 7130-7139
    • Kobayashi, A.1    Kang, M.2    Okawa, H.3    Ohtsuji, M.4    Zenke, Y.5    Chiba, T.6    Igarashi, K.7    Yamamoto, M.8
  • 22
    • 0030451213 scopus 로고    scopus 로고
    • NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
    • Chan K, Lu R, Chang JC, Kan YW. NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci USA 1996; 93:13943-8.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13943-13948
    • Chan, K.1    Lu, R.2    Chang, J.C.3    Kan, Y.W.4
  • 23
    • 4844225631 scopus 로고    scopus 로고
    • Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice
    • Li J, Stein T, Johnson J. Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice. Physiol Genomics 2004; 18:261-72.
    • (2004) Physiol Genomics , vol.18 , pp. 261-272
    • Li, J.1    Stein, T.2    Johnson, J.3
  • 24
    • 13044304201 scopus 로고    scopus 로고
    • Nrf2 is essential for protection against acute pulmonary injury in mice
    • Chan K, Kan Y. Nrf2 is essential for protection against acute pulmonary injury in mice. Proc Natl Acad Sci USA 1999; 96:12731-6.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12731-12736
    • Chan, K.1    Kan, Y.2
  • 25
    • 0035836698 scopus 로고    scopus 로고
    • An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen
    • Chan K, Han X, Kan Y. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc Natl Acad Sci USA 2001; 98:4611-6.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4611-4616
    • Chan, K.1    Han, X.2    Kan, Y.3
  • 26
    • 0035153227 scopus 로고    scopus 로고
    • High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
    • Enomoto A, Itoh K, Nagayoshi E, Haruta J, Kimura T, O'Connor T, Harada T, Yamamoto M. High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci 2001; 59:169-77.
    • (2001) Toxicol Sci , vol.59 , pp. 169-177
    • Enomoto, A.1    Itoh, K.2    Nagayoshi, E.3    Haruta, J.4    Kimura, T.5    O'Connor, T.6    Harada, T.7    Yamamoto, M.8
  • 27
    • 0035853157 scopus 로고    scopus 로고
    • Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
    • Ramos Gomez M, Kwak M, Dolan P, Itoh K, Yamamoto M, Talalay P, Kensler T. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci USA 2001; 98:3410-5.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3410-3415
    • Ramos Gomez, M.1    Kwak, M.2    Dolan, P.3    Itoh, K.4    Yamamoto, M.5    Talalay, P.6    Kensler, T.7
  • 28
    • 0036318224 scopus 로고    scopus 로고
    • Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound
    • Braun S, Hanselmann C, Gassmann M, auf dem Keller U, Born-Berclaz C, Chan K, Kan Y, Werner S. Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound. Mol Cell Biol 2002; 22:5492-505.
    • (2002) Mol Cell Biol , vol.22 , pp. 5492-5505
    • Braun, S.1    Hanselmann, C.2    Gassmann, M.3    auf dem4    Keller, U.5    Born-Berclaz, C.6    Chan, K.7    Kan, Y.8    Werner, S.9
  • 29
    • 0036319473 scopus 로고    scopus 로고
    • Activation of the antioxidant response element in primary cortical neuronal cultures derived from transgenic reporter mice
    • Johnson DA, Andrews GK, Xu W, Johnson JA. Activation of the antioxidant response element in primary cortical neuronal cultures derived from transgenic reporter mice. J Neurochem 2002; 81:1233-41.
    • (2002) J Neurochem , vol.81 , pp. 1233-1241
    • Johnson, D.A.1    Andrews, G.K.2    Xu, W.3    Johnson, J.A.4
  • 32
    • 15244359632 scopus 로고    scopus 로고
    • Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia
    • Xu Z, Chen L, Leung L, Yen T, Lee C, Chan J. Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. Proc Natl Acad Sci USA 2005; 102:4120-5.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 4120-4125
    • Xu, Z.1    Chen, L.2    Leung, L.3    Yen, T.4    Lee, C.5    Chan, J.6
  • 34
    • 21244472975 scopus 로고    scopus 로고
    • IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda S, Kamata H, Luo J, Leffert H, Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005; 121:977-90.
    • (2005) Cell , vol.121 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.3    Leffert, H.4    Karin, M.5
  • 35
    • 14844327760 scopus 로고    scopus 로고
    • Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
    • Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005; 120:649-61.
    • (2005) Cell , vol.120 , pp. 649-661
    • Kamata, H.1    Honda, S.2    Maeda, S.3    Chang, L.4    Hirata, H.5    Karin, M.6
  • 36
    • 33645799492 scopus 로고    scopus 로고
    • Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: Role of IKK, JNK, and ROS pathways
    • Schwabe R, Brenner D. Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol 2006; 290:583-9.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290 , pp. 583-589
    • Schwabe, R.1    Brenner, D.2
  • 37
    • 0025739254 scopus 로고
    • Reactive oxygen intermediates as apparently widely used messengers in the activation of the NFkappa B transcription factor and HIV-1
    • Schreck R, Rieber P, Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NFkappa B transcription factor and HIV-1. Embo J 1991; 10:2247-58.
    • (1991) Embo J , vol.10 , pp. 2247-2258
    • Schreck, R.1    Rieber, P.2    Baeuerle, P.A.3
  • 38
    • 33747590755 scopus 로고    scopus 로고
    • Evaluation of the role of nuclear factor-kappaB signaling in liver injury using genetic animal models
    • Luedde T, Beraza N, Trautwein C. Evaluation of the role of nuclear factor-kappaB signaling in liver injury using genetic animal models. J Gastroenterol Hepatol 2006; 21:43-6.
    • (2006) J Gastroenterol Hepatol , vol.21 , pp. 43-46
    • Luedde, T.1    Beraza, N.2    Trautwein, C.3
  • 39
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006; 440:944-8.
    • (2006) Nature , vol.440 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 40
    • 33244481462 scopus 로고    scopus 로고
    • Thr phosphorylation of IRS proteins: A molecular basis for insulin esistance
    • Zick Y. Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin esistance. Sci STKE 2005; 2005:4.
    • (2005) Sci STKE 2005 , pp. 4
    • Ser, Z.Y.1
  • 41
    • 33845542745 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction
    • Morino K, Petersen KF, Shulman GI. Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes 2006; 55:9-15.
    • (2006) Diabetes , vol.55 , pp. 9-15
    • Morino, K.1    Petersen, K.F.2    Shulman, G.I.3
  • 42
    • 10044265209 scopus 로고    scopus 로고
    • JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species
    • Ventura J, Cogswell P, Flavell R, Baldwin AJ, Davis R. JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev 2004; 18:2905-15.
    • (2004) Genes Dev , vol.18 , pp. 2905-2915
    • Ventura, J.1    Cogswell, P.2    Flavell, R.3    Baldwin, A.J.4    Davis, R.5
  • 43
    • 0037059330 scopus 로고    scopus 로고
    • Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
    • Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 2002; 277:1531-7.
    • (2002) J Biol Chem , vol.277 , pp. 1531-1537
    • Aguirre, V.1    Werner, E.D.2    Giraud, J.3    Lee, Y.H.4    Shoelson, S.E.5    White, M.F.6
  • 45
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NFkappaB
    • Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NFkappaB. Nat Med 2005; 11:183-90.
    • (2005) Nat Med , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6    Shoelson, S.E.7
  • 46
    • 0038398622 scopus 로고    scopus 로고
    • The insulin-like growth factor system and cancer
    • LeRoith D, Roberts CT, Jr. The insulin-like growth factor system and cancer. Cancer Lett 2003; 195:127-37.
    • (2003) Cancer Lett , vol.195 , pp. 127-137
    • LeRoith, D.1    Roberts Jr., C.T.2
  • 47
    • 30344445363 scopus 로고    scopus 로고
    • Ethanol reduces p38 kinase activation and cyclin D1 protein expression after partial hepatectomy in rats
    • Hsu M, Qiao L, Ho V, Zhang B, Zhang H, Teoh N, Dent P, Farrell G. Ethanol reduces p38 kinase activation and cyclin D1 protein expression after partial hepatectomy in rats. J Hepatol 2006; 44:375-82.
    • (2006) J Hepatol , vol.44 , pp. 375-382
    • Hsu, M.1    Qiao, L.2    Ho, V.3    Zhang, B.4    Zhang, H.5    Teoh, N.6    Dent, P.7    Farrell, G.8
  • 49
    • 17144395975 scopus 로고    scopus 로고
    • The activation of Akt/PKB signaling pathway and cell survival
    • Song G, Ouyang G, Bao S. The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 2005; 9:59-71.
    • (2005) J Cell Mol Med , vol.9 , pp. 59-71
    • Song, G.1    Ouyang, G.2    Bao, S.3
  • 50
    • 0034845958 scopus 로고    scopus 로고
    • PKB/Akt: A key mediator of cell proliferation, survival and insulin responses?
    • Lawlor M, Alessi D. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci 2001; 114:2903-10.
    • (2001) J Cell Sci , vol.114 , pp. 2903-2910
    • Lawlor, M.1    Alessi, D.2
  • 51
    • 0035949706 scopus 로고    scopus 로고
    • Hanausek M, Ganesh P, Walaszek Z, Arntzen C, Slaga T, Gutterman J. Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-ras mutations and aneuploidy in a murine skin carcinogenesis model. Proc Natl Acad Sci USA 2001; 98:11551-6.
    • Hanausek M, Ganesh P, Walaszek Z, Arntzen C, Slaga T, Gutterman J. Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-ras mutations and aneuploidy in a murine skin carcinogenesis model. Proc Natl Acad Sci USA 2001; 98:11551-6.
  • 52
    • 21144438719 scopus 로고    scopus 로고
    • Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells
    • Hyer M, Croxton R, Krajewska M, Krajewski S, Kress C, Lu M, Suh N, Sporn M, Cryns V, Zapata J, Reed J. Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells. Cancer Res 2005; 65:4799-808.
    • (2005) Cancer Res , vol.65 , pp. 4799-4808
    • Hyer, M.1    Croxton, R.2    Krajewska, M.3    Krajewski, S.4    Kress, C.5    Lu, M.6    Suh, N.7    Sporn, M.8    Cryns, V.9    Zapata, J.10    Reed, J.11


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