Rat models of autoimmune uveitis

Ophthalmic Research

Volumn 40, Issue 3-4, 2008, Pages 141-144

  Wildner, Gerhild ^a   Diedrichs Möhring, Maria ^a   Thurau, Stephan R ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Antigenic mimicry; Interphotoreceptor retinoid binding protein; Intravital fluorescence microscopy; Oral tolerance; Peptide; S antigen; T lymphocyte

Indexed keywords

AUTOANTIGEN; CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; CORTICOSTEROID; GREEN FLUORESCENT PROTEIN; HLA B27 ANTIGEN; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; PEPTIDE DERIVATIVE; RETINA ANTIGEN; RETINA S ANTIGEN;

AUTOIMMUNE DISEASE; AUTOIMMUNE UVEITIS; CROSS REACTION; DISEASE MODEL; DRUG DOSE REDUCTION; EXPERIMENTAL MODEL; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; LEWIS RAT; LYMPHOCYTE MIGRATION; MOLECULAR MIMICRY; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; RAT STRAIN; REGULATORY MECHANISM; RELAPSE; SHORT SURVEY; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UVEITIS;

ANIMALS; AUTOANTIGENS; AUTOIMMUNE DISEASES; DISEASE MODELS, ANIMAL; FOLLOW-UP STUDIES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MICROSCOPY, FLUORESCENCE; ORGANIC CHEMICALS; RATS; RATS, INBRED LEW; RETINA; T-LYMPHOCYTES; UVEITIS, ANTERIOR;

EID: 42449104936     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000119865     Document Type: Short Survey

References (11)

1. Wildner G, Thurau SR: Cross-reactivity between an HLA-B27-derived peptide and a retinal autoantigen peptide: a clue to major histocompatibility complex association with autoimmune disease. Eur J Immunol 1994;24:2579-2585.
2. Sanui H, Redmond TM, Hu LH, Kuwabara T, Margalit H, Cornette JL, Wiggert B, Chader GJ, Gery I: Synthetic peptides derived from IRBP induce EAU and EAP in Lewis rats. Curr Eye Res 1988;7:727-735.
3. Wildner G, Diedrichs Mohring M: Autoimmune uveitis induced by molecular mimicry of peptides from rotavirus, bovine casein and retinal S-antigen. Eur J Immunol 2003;33:2577-2587.
4. Thurau SR, Mempel TR, Flugel A, Diedrichs Mohring M, Krombach F, Kawakami N, Wildner G: The fate of autoreactive, GFP+ T cells in rat models of uveitis analyzed by intravital fluorescence microscopy and FACS. Int Immunol 2004;16:1573-1582.
5. Shao H, Shi H, Kaplan HJ, Sun D: Chronic recurrent autoimmune uveitis with progressive photoreceptor damage induced in rats by transfer of IRBP-specific T cells. J Neuroimmunol 2005;163:102-109.
6. Diedrichs-Möhring M, Hoffmann C, Wildner G: Antigen-dependent monophasic or recurrent autoimmune uveitis in rats. Int Immunol 2008;20:365-374.
7. Diedrichs Mohring M, Nelson PJ, Proudfoot AE, Thurau SR, Wildner G: The effect of the CC chemokine receptor antagonist Met-RANTES on experimental autoimmune uveitis and oral tolerance. J Neuroimmunol 2005;164:22-30.
8. Deeg CA, Thurau SR, Gerhards H, Ehrenhofer M, Wildner G, Kaspers B: Uveitis in horses induced by interphotoreceptor retinoid-binding protein is similar to the spontaneous disease. Eur J Immunol 2002;32:2598-2606.
9. Wildner G, Hunig T, Thurau SR: Orally induced, peptide-specific gamma/delta TCR+ cells suppress experimental autoimmune uveitis. Eur J Immunol 1996;26:2140-2148.
10. Wildner G, Thurau SR, Diedrichs Mohring M: Gamma-delta T cells as orally induced suppressor cells in rats: in vitro characterization. Ann NY Acad Sci 2004;1029:416-421.
11. Thurau SR, Diedrichs Mohring M, Fricke H, Burchardi C, Wildner G: Oral tolerance with an HLA-peptide mimicking retinal autoantigen as a treatment of autoimmune uveitis. Immunol Lett 1999;68:205-212.