Hemoglobin variants, hematological parameters and β-globin gene cluster haplotypes in an isolated Amerindian group from the Orinoco River Delta

Annals of Human Biology

Volumn 35, Issue 2, 2008, Pages 250-255

  Arends, Anabel ^a,b,d   Chacín, Marycarmen ^a,b   Bravo Urquiola, Martha ^a,b   Tibisay, Arends De O ^a,b   Álvarez, Maritza ^a   Castillo, Omar ^c   Guevara, Jose M ^a  

^a HOSPITAL UNIVERSITARIO DE CARACAS   (Venezuela)

^b Instituto Anatomico Jose Izquierdo Caracas   (Venezuela)

^c UNIVERSIDAD DE CARABOBO   (Venezuela)

^d NONE   (Venezuela)

Author keywords

globin gene haplotypes; Amerindians; HPFH

Indexed keywords

GLOBIN; HEMOGLOBIN F; HEMOGLOBIN VARIANT;

CHROMOSOME; DELTA; GENE; GENE EXPRESSION; GENETICS; HEMATOLOGY; HEMOGLOBIN;

ALLELE; AMERICAN INDIAN; ARTICLE; CHILD; CHROMOSOME MAP; ETHNIC AND RACIAL GROUPS; FEMALE; GENE DELETION; GENE FREQUENCY; GENE POOL; GENETICS; HAPLOTYPE; HETEROZYGOTE; HUMAN; MALE; NEGRO; PEDIGREE; VENEZUELA;

AFRICAN CONTINENTAL ANCESTRY GROUP; ALLELES; CHILD; CHROMOSOME MAPPING; FEMALE; FETAL HEMOGLOBIN; GENE FREQUENCY; GENE POOL; GLOBINS; HAPLOTYPES; HEMOGLOBINS, ABNORMAL; HETEROZYGOTE; HUMANS; INDIANS, SOUTH AMERICAN; MALE; PEDIGREE; POPULATION GROUPS; SEQUENCE DELETION; VENEZUELA;

DELTA AMACURO; ORINOCO DELTA; SOUTH AMERICA; VENEZUELA;

EID: 42449099335     PISSN: 03014460     EISSN: 14645033     Source Type: Journal    
DOI: 10.1080/03014460701877999     Document Type: Article

References (20)

1. Alter BP, Sabra CG, Efremonv GD, Grabely ME, Huisman, THJ. 1980. Globin chain electrophoresis: A new approach to the determination of the Aγ/Gγ ratio in fetal haemoglobin and to studies of globin synthesis. Br J Haematol 44:527-534.
2. S-globin gene in Blacks: The contribution of recurrent mutation or gene conversion or both. Proc Natl Acad Sci USA 81:853-856.
3. Arends A, Alvarez M, Velázquez D, Bravo M, Salazar R, Guevara JM, Castillo O. 2000. Determination of beta-globin gene cluster haplotypes and prevalence of alpha-thalassemia in sickle cell anemia patients in Venezuela. Am J Hematol 4:87-90.
4. Arends T. 1963. Frecuencia de hemoglobinas anormales en poblaciones humanas suramericanas. Acta Cient Venezol 1:46-47.
5. Arends T. 1975. Increased levels of F and/or A2 in Venezuelan subjects. In: Schmidt RM, editor. Abnormal haemoglobins and thalassemia, diagnostic aspects. New York: Academic Press. pp 229-246.
6. Arends T. 1992. Estructura genética de la población indígena de Venezuela. Caracas: Universidad de las Naciones Unidas.
7. Arends T, Gallango ML. 1964. Transferrin in Venezuelan Indians: High frequency of a slow-moving variant. Science 143:367-368.
8. Arends T, Gallango ML, Layrisse M, Wilbert J, Heinen HD. 1969. Albumin Warao: New type of human alloalbuminemia. Blood 33:414-420.
9. Betke K, Marti HR, Schlich I. 1959. Estimation of small percentages of fetal hemoglobin. Nature 184:1870-1878.
10. Castro de Guerra D, Hutz MH, Bortolini MC, Salzano FM. 1997. Beta-globin gene cluster haplotypes in an admixed Venezuelan population. Am J Phys Anthropol 9:323-327.
11. Gottardi E, Losekoot M, Fodde R, Saglio G, Camaschella C, Bernini LF. 1992. Rapid identification denaturing gradient gel electrophoresis of mutations in the γ-globin gene promoters in non-deletion type HPFH. Br J Haematol 80:533-538.
12. Guerreiro JF, Figueiredo MS, Santos SEB, Zago A. 1992. β-globin gene cluster haplotypes in Yanomama Indians from the Amazon Region of Brazil. Hum Genet 89:629-631.
13. 2. J Lab Clin Med 86:700-702.
14. Kleihauer E, Braun H, Betke K. 1957. Demonstration von fetalem haemoglobin in den Erytrocyten eines Blutausstrichs. Klinische Wochenschrift 35:635-636.
15. Layrisse Z, Layrisse M, Heinen HD, Wilbert J. 1976. The histocompatibility system in the Warao Indians of Venezuela. Science 194:1135-1138.
16. Long JC, Chakravarti A, Boehm CD, Antonarakis S, Kazazian HH Jr. 1990. Phylogeny of human β-globin haplotypes and its implications for recent human evolution. Am J Phys Anthropol 81:113-130.
17. OCEI. 1995. Censo Indígena de Venezuela, 1992. Nomenclador de Asentamientos, Tomo II. Caracas: Oficina Central de Estadística e Informática.
18. Pante-De-Sousa G, De Cassia Moushinho-Ribeiro R, Melo Dos Santos EJ, Guerreiro JF. 1999. β-globin haplotypes analysis in Afro-Brazilians from the Amazon Region: Evidence for a significant gene flow Atlantic West Africa. Ann Hum Biol 26:365-373.
19. Poncz M, Solowiejczyk D, Harpel B, Mory Y, Schwartz E, Surrey S. 1982. Construction of human gene libraries from small amounts of peripheral blood: Analysis of β like globin genes. Hemoglobin 6:27-36.
20. Sutton M, Boushassira EE, Nagel RL. 1989. Polymerase chain reaction amplification applied to the determination of beta globin gene cluster haplotypes. Am J Hematol 32:66-69.