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Volumn 51, Issue 4, 2008, Pages 418-423

Differential effects of epsilon-aminocaproic acid and aprotinin on matrix metalloproteinase release in patients following cardiopulmonary bypass

Author keywords

Aprotinin; Cardiac surgery; Epsilon aminocaproic acid; Interleukins; Matrix metalloproteinases

Indexed keywords

AMINOCAPROIC ACID; APROTININ; GELATINASE B; INTERLEUKIN 6; NEUTROPHIL COLLAGENASE;

EID: 42449095077     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e318168400a     Document Type: Article
Times cited : (11)

References (39)
  • 1
    • 0037155784 scopus 로고    scopus 로고
    • Matrix metalloproteinases. Regulation and dysregulation in the failing heart
    • Spinale FG. Matrix metalloproteinases. Regulation and dysregulation in the failing heart. Circ Res. 2002;90:520-530.
    • (2002) Circ Res , vol.90 , pp. 520-530
    • Spinale, F.G.1
  • 2
    • 0037693895 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structure, function, and biochemistry
    • Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res. 2003; 92:827-839.
    • (2003) Circ Res , vol.92 , pp. 827-839
    • Visse, R.1    Nagase, H.2
  • 3
    • 31344447802 scopus 로고    scopus 로고
    • Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates
    • Newby AC. Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates. Cardiovasc Res. 2006;69:614-624.
    • (2006) Cardiovasc Res , vol.69 , pp. 614-624
    • Newby, A.C.1
  • 4
    • 0036838673 scopus 로고    scopus 로고
    • Collagen degradation in a murine myocarditis model: Relevance of matrix metalloproteinase in association with inflammatory induction
    • Li J, Schwimmbeck PL, Tschope C, et al. Collagen degradation in a murine myocarditis model: relevance of matrix metalloproteinase in association with inflammatory induction. Cardiovasc Res. 2002;56: 235-247.
    • (2002) Cardiovasc Res , vol.56 , pp. 235-247
    • Li, J.1    Schwimmbeck, P.L.2    Tschope, C.3
  • 5
    • 0038796894 scopus 로고    scopus 로고
    • Region- and type-specific induction of matrix metalloproteinases in post-myocardial infarction remodeling
    • Wilson EM, Moainie SL, Baskin JM, et al. Region- and type-specific induction of matrix metalloproteinases in post-myocardial infarction remodeling. Circulation. 2003;107:2857-2863.
    • (2003) Circulation , vol.107 , pp. 2857-2863
    • Wilson, E.M.1    Moainie, S.L.2    Baskin, J.M.3
  • 6
    • 33644874476 scopus 로고    scopus 로고
    • Matrix metalloproteinase 2 is associated with stable and matrix metalloproteinases 8 and 9 with vulnerable carotid atherosclerotic lesions: A study in human endarterectomy specimen pointing to a role for different extracellular matrix metalloproteinase inducer glycosylation forms
    • Sluijter JP, Pulskens WP, Schoneveld AH, et al. Matrix metalloproteinase 2 is associated with stable and matrix metalloproteinases 8 and 9 with vulnerable carotid atherosclerotic lesions: a study in human endarterectomy specimen pointing to a role for different extracellular matrix metalloproteinase inducer glycosylation forms. Stroke. 2006;37:235-239.
    • (2006) Stroke , vol.37 , pp. 235-239
    • Sluijter, J.P.1    Pulskens, W.P.2    Schoneveld, A.H.3
  • 7
    • 0035899898 scopus 로고    scopus 로고
    • Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma: A novel collagenolytic pathway suggested by transcriptional profiling
    • Herman MP, Sukhova GK, Libby P, et al. Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma: a novel collagenolytic pathway suggested by transcriptional profiling. Circulation. 2001;104:1899-1904.
    • (2001) Circulation , vol.104 , pp. 1899-1904
    • Herman, M.P.1    Sukhova, G.K.2    Libby, P.3
  • 8
    • 34047274968 scopus 로고    scopus 로고
    • Proteinase systems and thoracic aortic aneurysm progression
    • Barbour JR, Spinale FG, Ikonomidis JS. Proteinase systems and thoracic aortic aneurysm progression. J Surg Res. 2007;139:292-307.
    • (2007) J Surg Res , vol.139 , pp. 292-307
    • Barbour, J.R.1    Spinale, F.G.2    Ikonomidis, J.S.3
  • 9
    • 0037417940 scopus 로고    scopus 로고
    • Myocardial infarct expansion and matrix metalloproteinase inhibition
    • Mukherjee R, Brinsa TA, Dowdy KB, et al. Myocardial infarct expansion and matrix metalloproteinase inhibition. Circulation. 2003;107:618-625.
    • (2003) Circulation , vol.107 , pp. 618-625
    • Mukherjee, R.1    Brinsa, T.A.2    Dowdy, K.B.3
  • 10
    • 33748479022 scopus 로고    scopus 로고
    • Specific temporal profile of matrix metalloproteinase release occurs in patients following myocardial infarction: Relation to left ventricular remodeling
    • Webb CS, Bonnema DD, Ahmed SH, et al. Specific temporal profile of matrix metalloproteinase release occurs in patients following myocardial infarction: relation to left ventricular remodeling. Circulation. 2006;114: 1020-1027.
    • (2006) Circulation , vol.114 , pp. 1020-1027
    • Webb, C.S.1    Bonnema, D.D.2    Ahmed, S.H.3
  • 11
    • 33646439273 scopus 로고    scopus 로고
    • Matrix metalloproteinases/ tissue inhibitors of metalloproteinases: Relationship between changes in proteolytic determinants of matrix composition and structural, functional & clinical manifestations of hypertensive heart disease
    • Ahmed SH, Clark LL, Pennington WR, et al. Matrix metalloproteinases/ tissue inhibitors of metalloproteinases: relationship between changes in proteolytic determinants of matrix composition and structural, functional & clinical manifestations of hypertensive heart disease. Circulation. 2006;113: 2089-2096.
    • (2006) Circulation , vol.113 , pp. 2089-2096
    • Ahmed, S.H.1    Clark, L.L.2    Pennington, W.R.3
  • 12
    • 0034996905 scopus 로고    scopus 로고
    • Cardiopulmonary bypass induces the synthesis and release of matrix metalloproteinases
    • Joffs C, Gunasinghe HR, Multani MM, et al. Cardiopulmonary bypass induces the synthesis and release of matrix metalloproteinases. Ann Thorac Surg. 2001;71:1518-1523.
    • (2001) Ann Thorac Surg , vol.71 , pp. 1518-1523
    • Joffs, C.1    Gunasinghe, H.R.2    Multani, M.M.3
  • 13
    • 0035497305 scopus 로고    scopus 로고
    • Cardiac surgery increases the activity of matrix metalloproteinases and nitric oxide synthase in human hearts
    • Mayers I, Hurst T, Puttagunta L, et al. Cardiac surgery increases the activity of matrix metalloproteinases and nitric oxide synthase in human hearts. J Thorac Cardiovasc Surg. 2001;122:746-752.
    • (2001) J Thorac Cardiovasc Surg , vol.122 , pp. 746-752
    • Mayers, I.1    Hurst, T.2    Puttagunta, L.3
  • 14
    • 19044390519 scopus 로고    scopus 로고
    • Neutrophil-mediated secretion and activation of matrix metalloproteinase-9 during cardiac surgery with cardiopulmonary bypass
    • Lin TC, Li CY, Tsai CS, et al. Neutrophil-mediated secretion and activation of matrix metalloproteinase-9 during cardiac surgery with cardiopulmonary bypass. Anesth Analg. 2005;100:1554-1560.
    • (2005) Anesth Analg , vol.100 , pp. 1554-1560
    • Lin, T.C.1    Li, C.Y.2    Tsai, C.S.3
  • 15
    • 0036300758 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and tumour necrosis factor alpha release during cardiopulmonary bypass
    • Galley HF, Macaulay GD, Webster NR. Matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and tumour necrosis factor alpha release during cardiopulmonary bypass. Anaesthesia. 2002;57:659-662.
    • (2002) Anaesthesia , vol.57 , pp. 659-662
    • Galley, H.F.1    Macaulay, G.D.2    Webster, N.R.3
  • 16
    • 31344466167 scopus 로고    scopus 로고
    • Pathways of matrix metalloproteinase induction in heart failure: Bioactive molecules and transcriptional regulation
    • Deschamps AM, Spinale FG. Pathways of matrix metalloproteinase induction in heart failure: bioactive molecules and transcriptional regulation. Cardiovasc Res. 2006;69:666-676.
    • (2006) Cardiovasc Res , vol.69 , pp. 666-676
    • Deschamps, A.M.1    Spinale, F.G.2
  • 17
    • 31344477494 scopus 로고    scopus 로고
    • Myocardial proteases and matrix remodeling in inflammatory heart disease
    • Rutschow S, Li J, Schultheiss HP, et al. Myocardial proteases and matrix remodeling in inflammatory heart disease. Cardiovasc Res. 2006;69: 646-656.
    • (2006) Cardiovasc Res , vol.69 , pp. 646-656
    • Rutschow, S.1    Li, J.2    Schultheiss, H.P.3
  • 18
    • 0033547701 scopus 로고    scopus 로고
    • Is E-aminocaproic acid as effective as aprotinin in reducing bleeding with cardiac surgery?
    • Munoz JJ, Birkmeyer NJ, Birkmeyer JD, et al. Is E-aminocaproic acid as effective as aprotinin in reducing bleeding with cardiac surgery? Circulation. 1999;99:81-89.
    • (1999) Circulation , vol.99 , pp. 81-89
    • Munoz, J.J.1    Birkmeyer, N.J.2    Birkmeyer, J.D.3
  • 19
    • 0023608558 scopus 로고
    • Effects of aprotinin on hemostatic mechanisms during cardiopulmonary bypass
    • van Oeveren W, Jansen NJ, Bidstrup BP, et al. Effects of aprotinin on hemostatic mechanisms during cardiopulmonary bypass. Ann Thorac Surg. 1987;44:640-645.
    • (1987) Ann Thorac Surg , vol.44 , pp. 640-645
    • van Oeveren, W.1    Jansen, N.J.2    Bidstrup, B.P.3
  • 20
    • 0023204701 scopus 로고
    • Effect of aprotinin on need for blood transfusion after repeat open-heart surgery
    • Royston D, Bidstrup BP, Taylor KM, et al. Effect of aprotinin on need for blood transfusion after repeat open-heart surgery. Lancet. 1987;2:1289-1291.
    • (1987) Lancet , vol.2 , pp. 1289-1291
    • Royston, D.1    Bidstrup, B.P.2    Taylor, K.M.3
  • 21
    • 4444380033 scopus 로고    scopus 로고
    • Effect of aprotinin on clinical outcomes in a coronary arterty bypass graft surgery: A systematic review and meta-analysis of randomized clinical trials
    • Sedrakyan A, Treasure T, Elefteriades JA. Effect of aprotinin on clinical outcomes in a coronary arterty bypass graft surgery: A systematic review and meta-analysis of randomized clinical trials. J Thorac Cardiovasc Surg. 2004;128:442-448.
    • (2004) J Thorac Cardiovasc Surg , vol.128 , pp. 442-448
    • Sedrakyan, A.1    Treasure, T.2    Elefteriades, J.A.3
  • 22
    • 0031284642 scopus 로고    scopus 로고
    • The effects of epsilon-aminocaproic acid on fibrinolysis and thrombin generation during cardiac surgery
    • Slaughter TF, Faghih F, Greenberg CS, et al. The effects of epsilon-aminocaproic acid on fibrinolysis and thrombin generation during cardiac surgery. Anesth Analg. 1997;85:1221-1226.
    • (1997) Anesth Analg , vol.85 , pp. 1221-1226
    • Slaughter, T.F.1    Faghih, F.2    Greenberg, C.S.3
  • 23
    • 0035118319 scopus 로고    scopus 로고
    • Aprotinin and the systematic inflammatory response after cardiopulmonary bypass
    • Mojcik CF, Levy JH. Aprotinin and the systematic inflammatory response after cardiopulmonary bypass. Ann Thorac Surg. 2001;71:745-754.
    • (2001) Ann Thorac Surg , vol.71 , pp. 745-754
    • Mojcik, C.F.1    Levy, J.H.2
  • 24
    • 0035171791 scopus 로고    scopus 로고
    • New anti-inflammatory and platelet-preserving effects of aprotinin
    • Landis RC, Haskard DO, Taylor KM. New anti-inflammatory and platelet-preserving effects of aprotinin. Ann Thorac Surg. 2001;72: S1808-S1813.
    • (2001) Ann Thorac Surg , vol.72
    • Landis, R.C.1    Haskard, D.O.2    Taylor, K.M.3
  • 25
    • 0033951158 scopus 로고    scopus 로고
    • Cardiopulmonary support and physiology. Aprotinin preserves myocardial biochemical function during cold storage through suppression of tumor necrosis factor
    • Bull D, Connors R, Albanil A, et al. Cardiopulmonary support and physiology. Aprotinin preserves myocardial biochemical function during cold storage through suppression of tumor necrosis factor. J Thorac Cardiovasc Surg. 2000;119:242-250.
    • (2000) J Thorac Cardiovasc Surg , vol.119 , pp. 242-250
    • Bull, D.1    Connors, R.2    Albanil, A.3
  • 26
    • 1442290404 scopus 로고    scopus 로고
    • Effects of E-aminocaproic acid and aprotinin on leukocyte-platelet adhesion in patients undergoing cardiac surgery
    • Greilich PE, Brouse CF, Rinder CS, et al. Effects of E-aminocaproic acid and aprotinin on leukocyte-platelet adhesion in patients undergoing cardiac surgery. Anesthesiology. 2004;100:1-17.
    • (2004) Anesthesiology , vol.100 , pp. 1-17
    • Greilich, P.E.1    Brouse, C.F.2    Rinder, C.S.3
  • 27
    • 34249913425 scopus 로고    scopus 로고
    • Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery
    • Brown JR, Birkmeyer NJ, O'Connor GT. Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery. Circulation. 2007;115:2801-2813.
    • (2007) Circulation , vol.115 , pp. 2801-2813
    • Brown, J.R.1    Birkmeyer, N.J.2    O'Connor, G.T.3
  • 28
    • 31344467254 scopus 로고    scopus 로고
    • The risk associated with aprotinin in cardiac surgery
    • Mangano DT, Tudor IC, Dietzel C. The risk associated with aprotinin in cardiac surgery. NEJM. 2006;354:353-365.
    • (2006) NEJM , vol.354 , pp. 353-365
    • Mangano, D.T.1    Tudor, I.C.2    Dietzel, C.3
  • 29
    • 0033524140 scopus 로고    scopus 로고
    • Pharmacological strategies to decrease excessive blood loss in cardiac surgery: A meta-analysis of clinically relevant endpoints
    • Levi M, Cromheecke ME, de Jonge E, et al. Pharmacological strategies to decrease excessive blood loss in cardiac surgery: a meta-analysis of clinically relevant endpoints. Lancet. 1999;354:1940-1947.
    • (1999) Lancet , vol.354 , pp. 1940-1947
    • Levi, M.1    Cromheecke, M.E.2    de Jonge, E.3
  • 30
    • 0035908926 scopus 로고    scopus 로고
    • Aprotinin but not epsilon-aminocaproic acid decreases interleukin-10 after cardiac surgery with extracorporeal circulation: Randomized, double-blind, placebo-controlled study in patients receiving aprotinin and epsilon-aminocaproic acid
    • Greilich PE, Okada K, Latham P, et al. Aprotinin but not epsilon-aminocaproic acid decreases interleukin-10 after cardiac surgery with extracorporeal circulation: randomized, double-blind, placebo-controlled study in patients receiving aprotinin and epsilon-aminocaproic acid. Circulation. 2001;104:I265-I269.
    • (2001) Circulation , vol.104
    • Greilich, P.E.1    Okada, K.2    Latham, P.3
  • 31
    • 0037693895 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structure, function, and biochemistry
    • Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res. 92: 827-839, 2003.
    • (2003) Circ Res , vol.92 , pp. 827-839
    • Visse, R.1    Nagase, H.2
  • 32
    • 0033088484 scopus 로고    scopus 로고
    • Human neutrophils secrete gelatinase B in vitro and in vivo in response to endotoxin and proinflammatory mediators
    • Pugin J, Widmer MC, Kossodo S, et al. Human neutrophils secrete gelatinase B in vitro and in vivo in response to endotoxin and proinflammatory mediators. Am J Respir Cell Mol Biol. 1999;20:458-464.
    • (1999) Am J Respir Cell Mol Biol , vol.20 , pp. 458-464
    • Pugin, J.1    Widmer, M.C.2    Kossodo, S.3
  • 33
    • 0037189584 scopus 로고    scopus 로고
    • Modulation of the catalytic activity of neutrophil collagenase MMP-8 on bovine collagen I. Role of the activation cleavage and of the hemopexin-like domain
    • Gioia M, Fasciglione GF, Marini S, et al. Modulation of the catalytic activity of neutrophil collagenase MMP-8 on bovine collagen I. Role of the activation cleavage and of the hemopexin-like domain. J Biol Chem. 2002;277:23123-23130.
    • (2002) J Biol Chem , vol.277 , pp. 23123-23130
    • Gioia, M.1    Fasciglione, G.F.2    Marini, S.3
  • 34
    • 33645853478 scopus 로고    scopus 로고
    • Prestorage leukoreduction prevents accumulation of matrix metalloproteinase 9 in stored blood
    • discussion, 400
    • Frake PC, Smith HE, Chen LF, et al. Prestorage leukoreduction prevents accumulation of matrix metalloproteinase 9 in stored blood. Arch Surg. 2006;141:396-400; discussion, 400.
    • (2006) Arch Surg , vol.141 , pp. 396-400
    • Frake, P.C.1    Smith, H.E.2    Chen, L.F.3
  • 35
    • 0033861084 scopus 로고    scopus 로고
    • Plasma aprotinin concentrations during cardiac surgery: Full- versus half-dose regimens
    • Beath SM, Nuttall GA, Fass DN, et al. Plasma aprotinin concentrations during cardiac surgery: full- versus half-dose regimens. Anesth Analg. 2000;91:257-264.
    • (2000) Anesth Analg , vol.91 , pp. 257-264
    • Beath, S.M.1    Nuttall, G.A.2    Fass, D.N.3
  • 36
    • 14144256374 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Their function in tissue repair
    • Toy LW. Matrix metalloproteinases: their function in tissue repair. J Wound Care. 2005;14:20-22.
    • (2005) J Wound Care , vol.14 , pp. 20-22
    • Toy, L.W.1
  • 37
    • 0034764101 scopus 로고    scopus 로고
    • Proteolytic events of wound-healing-coordinated interactions among matrix metalloproteinases (MMPs), integrins, and extracellular matrix molecules
    • Steffensen B, Hakkinen L, Larjava H. Proteolytic events of wound-healing-coordinated interactions among matrix metalloproteinases (MMPs), integrins, and extracellular matrix molecules. Crit Rev Oral Biol Med. 2001;12:373-398.
    • (2001) Crit Rev Oral Biol Med , vol.12 , pp. 373-398
    • Steffensen, B.1    Hakkinen, L.2    Larjava, H.3
  • 38
    • 34748882511 scopus 로고    scopus 로고
    • Aprotinin does not increase the risk of renal failure in cardiac surgery patients
    • Furnary AP, Wu Y, Hiratzka LF, et al. Aprotinin does not increase the risk of renal failure in cardiac surgery patients. Circulation. 2007;116(Suppl 11):I127-I133.
    • (2007) Circulation , vol.116 , Issue.SUPPL. 11
    • Furnary, A.P.1    Wu, Y.2    Hiratzka, L.F.3
  • 39
    • 42449153146 scopus 로고    scopus 로고
    • American Heart Association Advisory:, Trasylol at FDA request. November Available at
    • American Heart Association Advisory: Bayer suspends marketing of aprotinin (Trasylol) at FDA request. November 2007 Available at: http://www.informz.net/heart/archives/archive_518051.html.
    • (2007) Bayer suspends marketing of aprotinin


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